World's Best Scientists 2026 revealed!

D-Index & Metrics

Engineering and Technology

D-Index
62
Citations
20313
World Ranking
1849
National Ranking
53

Molecular Biology

D-Index
72
Citations
25662
World Ranking
1305
National Ranking
97

Overview

Rolf Backofen is affiliated with the University of Freiburg in Germany and has contributed extensively to the field of Biochemistry, Genetics and Molecular Biology. Their research covers multiple subfields, including Molecular Biology, Genetics, Cancer Research, Immunology, and Ecology.

Their primary research topics encompass:

  • RNA and protein synthesis mechanisms
  • RNA modifications and cancer
  • RNA Research and Splicing
  • Genomics and Phylogenetic Studies
  • CRISPR and Genetic Engineering
  • Bacterial Genetics and Biotechnology
  • Bacteriophages and microbial interactions

Backofen has published their work predominantly in several scientific venues. Frequent publication platforms include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Bioinformatics
  • GigaScience
  • Nucleic Acids Research
  • microLife

Notable recent papers authored or co-authored by Backofen are:

  • pyGenomeTracks: reproducible plots for multivariate genomic datasets, 2020, Bioinformatics
  • Galaxy HiCExplorer 3: a web server for reproducible Hi-C, capture Hi-C and single-cell Hi-C data analysis, quality control and visualization, 2020, Nucleic Acids Research
  • Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N6-carboxymethyllysine, 2022, Nature Neuroscience
  • Temporospatial distribution and transcriptional profile of retinal microglia in the oxygen-induced retinopathy mouse model, 2020, Glia
  • CRISPRidentify: identification of CRISPR arrays using machine learning approach, 2020, Nucleic Acids Research

Frequent co-authors include:

  • Omer S. Alkhnbashi
  • Björn Grüning
  • Rick Gelhausen
  • Alexander Mitrofanov
  • Cynthia M. Sharma

Best Publications

  • An updated evolutionary classification of CRISPR–Cas systems

    Kira S. Makarova;Yuri I. Wolf;Omer S. Alkhnbashi;Fabrizio Costa

  • Evolutionary classification of CRISPR-Cas systems: a burst of class 2 and derived variants.

    Kira S. Makarova;Yuri I. Wolf;Jaime Iranzo;Sergey A. Shmakov

  • Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations.

    Desireé Schubert;Desireé Schubert;Claudia Bode;Rupert Kenefeck;Tie Zheng Hou

  • IntaRNA 2.0: enhanced and customizable prediction of RNA-RNA interactions

    Martin Mann;Patrick R. Wright;Rolf Backofen

  • IntaRNA: efficient prediction of bacterial sRNA targets incorporating target site accessibility and seed regions

    Anke Busch;Andreas S. Richter;Rolf Backofen

  • Inferring noncoding RNA families and classes by means of genome-scale structure-based clustering.

    Sebastian Will;Kristin Reiche;Ivo L Hofacker;Peter F Stadler

  • DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome

    Tuğçe Aktaş;İbrahim Avşar Ilık;Daniel Maticzka;Vivek Bhardwaj;Vivek Bhardwaj

  • pyGenomeTracks: reproducible plots for multivariate genomic datasets.

    Lucille Lopez-Delisle;Leily Rabbani;Joachim Wolff;Vivek Bhardwaj

  • Inferring non-coding RNA families and classes by means of genome-scale structure-based clustering

    Ivo Hofacker;Peter Stadler;Sebastian Will;Rolf Backofen

  • LocARNA-P: Accurate boundary prediction and improved detection of structural RNAs

    Sebastian Will;Tejal Joshi;Ivo L. Hofacker;Peter F. Stadler

  • Galaxy HiCExplorer 3: a web server for reproducible Hi-C, capture Hi-C and single-cell Hi-C data analysis, quality control and visualization.

    Joachim Wolff;Leily Rabbani;Ralf Gilsbach;Ralf Gilsbach;Gautier Richard

  • CopraRNA and IntaRNA: predicting small RNA targets, networks and interaction domains

    Patrick R. Wright;Jens Georg;Martin Mann;Dragos Alexandru Sorescu

  • Dynamic DNA methylation orchestrates cardiomyocyte development, maturation and disease

    Ralf Gilsbach;Sebastian Preissl;Björn A. Grüning;Tilman Schnick

  • COMPUTATIONAL MOLECULAR BIOLOGY: AN INTRODUCTION

    Peter Clote;Rolf Backofen

  • Global RNA recognition patterns of post-transcriptional regulators Hfq and CsrA revealed by UV crosslinking in vivo.

    Erik Holmqvist;Patrick R Wright;Lei Li;Thorsten Bischler

  • GraphProt: modeling binding preferences of RNA-binding proteins

    Daniel Maticzka;Sita J Lange;Fabrizio Costa;Rolf Backofen

  • Galaxy HiCExplorer: a web server for reproducible Hi-C data analysis, quality control and visualization

    Joachim Wolff;Vivek Bhardwaj;Vivek Bhardwaj;Stephan Nothjunge;Gautier Richard;Gautier Richard

  • Comparative genomics boosts target prediction for bacterial small RNAs

    Patrick R. Wright;Andreas S. Richter;Kai Papenfort;Kai Papenfort;Martin Mann

  • Freiburg RNA Tools: a web server integrating IntaRNA, ExpaRNA and LocARNA

    Cameron Smith;Steffen Heyne;Andreas S. Richter;Sebastian Will

  • The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 in breast cancer progression

    Yashar S. Niknafs;Sumin Han;Teng Ma;Corey Speers

  • MARNA: multiple alignment and consensus structure prediction of RNAs based on sequence structure comparisons

    Sven Siebert;Rolf Backofen

  • Pre-mRNA Secondary Structures Influence Exon Recognition

    Michael Hiller;Zhaiyi Zhang;Rolf Backofen;Stefan Stamm;Stefan Stamm

Frequent Co-Authors

Peter F. Stadler
Peter F. Stadler Leipzig University
Ivo L. Hofacker
Ivo L. Hofacker University of Vienna
Matthias Platzer
Matthias Platzer Leibniz Association
Wolfgang R. Hess
Wolfgang R. Hess University of Freiburg
Asifa Akhtar
Asifa Akhtar Max Planck Society
Gad M. Landau
Gad M. Landau University of Haifa
Jan Gorodkin
Jan Gorodkin University of Copenhagen
Ruth A. Schmitz
Ruth A. Schmitz Kiel University
Stefan Schreiber
Stefan Schreiber Kiel University
Roger A. Garrett
Roger A. Garrett University of Copenhagen

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