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Molecular Biology

D-Index
48
Citations
10346
World Ranking
2672
National Ranking
208

Overview

Parmjit S. Jat is affiliated with University College London in the United Kingdom. Their research spans multiple fields focusing primarily on Medicine, alongside Biochemistry, Genetics, and Molecular Biology. Subfields of study include Molecular Biology, Neurology, Physiology, Oncology, and Pulmonary and Respiratory Medicine.

Their academic output includes publications in several notable scientific venues, with frequent contributions to bioRxiv (Cold Spring Harbor Laboratory), Journal of Molecular Biology, Scientific Reports, Frontiers in Cell and Developmental Biology, and The Lancet Neurology.

Key topics covered in Parmjit S. Jat's work include:

  • Prion Diseases and Protein Misfolding
  • Neurological diseases and metabolism
  • Alzheimer's disease research and treatments
  • Telomeres, Telomerase, and Senescence
  • Cancer-related Molecular Pathways
  • Renal cell carcinoma treatment
  • Brain Metastases and Treatment

Their recent papers are as follows:

  • "Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype" (2021) published in Frontiers in Cell and Developmental Biology
  • "Identification of novel risk loci and causal insights for sporadic Creutzfeldt-Jakob disease: a genome-wide association study" (2020) published in The Lancet Neurology
  • "Tumor heterogeneity in VHL drives metastasis in clear cell renal cell carcinoma" (2023) published in Signal Transduction and Targeted Therapy
  • "Highly infectious prions are not directly neurotoxic" (2020) published in Proceedings of the National Academy of Sciences
  • "Brazilin Removes Toxic Alpha-Synuclein and Seeding Competent Assemblies from Parkinson Brain by Altering Conformational Equilibrium" (2021) published in Journal of Molecular Biology

Collaboration forms a significant part of their research profile, with frequent co-authors including John Collinge, Christian Schmidt, Iryna Benilova, M. Reilly, and Savroop Bhamra. These collaborations are documented with multiple joint publications, highlighting a network within the biomedical research community focused on neurodegenerative diseases and molecular biology.

Best Publications

  • Direct derivation of conditionally immortal cell lines from an H-2Kb-tsA58 transgenic mouse.

    Parmjit S. Jat;Mark D. Noble;Paris Ataliotis;Yujiro Tanaka

  • Cell lines established by a temperature-sensitive simian virus 40 large-T-antigen gene are growth restricted at the nonpermissive temperature.

    P S Jat;P A Sharp

  • ESTABLISHMENT OF CONDITIONALLY IMMORTALIZED EPITHELIAL-CELL LINES FROM BOTH COLON AND SMALL-INTESTINE OF ADULT H-2KB-TSA58 TRANSGENIC MICE

    R H Whitehead;P E VanEeden;M D Noble;P Ataliotis

  • Immortalization of precursor cells from the mammalian CNS.

    K. Frederiksen;P.S. Jat;N. Valtz;D. Levy

  • A selective PIKfyve inhibitor blocks PtdIns(3,5)P2 production and disrupts endomembrane transport and retroviral budding

    Harold B J Jefferies;Frank T. Cooke;Parmjit S. Jat;Christine Boucheron

  • PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons.

    Alison Wood-Kaczmar;Sonia Gandhi;Zhi Yao;Andrey S. Y. Abramov

  • Roles of hepatocyte growth factor/scatter factor and the met receptor in the early development of the metanephros.

    A S Woolf;M Kolatsi-Joannou;P Hardman;E Andermarcher

  • MYOGENIC CELL-LINES DERIVED FROM TRANSGENIC MICE CARRYING A THERMOLABILE T-ANTIGEN - A MODEL SYSTEM FOR THE DERIVATION OF TISSUE-SPECIFIC AND MUTATION-SPECIFIC CELL-LINES

    J.E. Morgan;J.R. Beauchamp;C.N. Pagel;M. Peckham

  • Conditional immortalization of freshly isolated human mammary fibroblasts and endothelial cells.

    Michael J. O'Hare;Jacquelyn Bond;Catherine Clarke;Yasuhiro Takeuchi

  • Recombinant retroviruses encoding simian virus 40 large T antigen and polyomavirus large and middle T antigens.

    P S Jat;C L Cepko;R C Mulligan;P A Sharp

  • Recovery of spatial learning by grafts of a conditionally immortalized hippocampal neuroepithelial cell line into the ischaemia-lesioned hippocampus

    J.D Sinden;F Rashid-Doubell;T.R Kershaw;A Nelson

  • cDNA microarray analysis of genes associated with ERBB2 (HER2/neu) overexpression in human mammary luminal epithelial cells

    Alan Mackay;Chris Jones;Tim Dexter;Ricardo L A Silva

  • Activation of Nuclear Factor-kappa B signalling promotes cellular senescence

    Emilie Rovillain;Louise Mansfield;Catia Caetano;Monica Alvarez-Fernandez

  • Rapid cell-surface prion protein conversion revealed using a novel cell system

    R. Goold;S. Rabbanian;L. Sutton;R. Andre

  • Large T antigens of simian virus 40 and polyomavirus efficiently establish primary fibroblasts.

    P S Jat;P A Sharp

  • Abnormalities of the retinoblastoma gene in the pathogenesis of acute leukemia

    HG Ahuja;PS Jat;A Foti;M Bar-Eli

  • Accumulation of p16INK4a in mouse fibroblasts as a function of replicative senescence and not of retinoblastoma gene status.

    Ignacio Palmero;Beth McConnell;David Parry;Sharon Brookes

  • Localization of DNA sequences necessary for transcription of the rabbit β-globin gene in vitro

    G.C. Grosveld;C.K. Shewmaker;P. Jat;R.A. Flavell

  • Establishment of the epithelial-specific transcriptome of normal and malignant human breast cells based on MPSS and array expression data

    Anita Grigoriadis;Alan Mackay;Jorge S. Reis-Filho;Dawn Steele

  • Simian Virus 40 Large T Antigen Disrupts Genome Integrity and Activates a DNA Damage Response via Bub1 Binding

    Jennifer Hein;Sergei Boichuk;Jiaping Wu;Yuan Cheng

Frequent Co-Authors

John Collinge
John Collinge University College London
Mark Noble
Mark Noble University of Rochester
Sunil R. Lakhani
Sunil R. Lakhani University of Queensland
Andrew K. Groves
Andrew K. Groves Baylor College of Medicine
Rainer Cramer
Rainer Cramer University of Reading
Michael D. Waterfield
Michael D. Waterfield Ludwig Cancer Research
Sebastian Brandner
Sebastian Brandner University College London
Thomas M. Roberts
Thomas M. Roberts Harvard University
Sarah J. Tabrizi
Sarah J. Tabrizi University College London
Nicholas W. Wood
Nicholas W. Wood University College London

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