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Markus Loeffler

Markus Loeffler

D-Index & Metrics

Medicine

D-Index
115
Citations
60106
World Ranking
4473
National Ranking
244

Overview

Markus Loeffler is affiliated with Leipzig University in Germany. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Within these fields, Loeffler has contributed extensively to subfields such as Genetics, Molecular Biology, Pathology and Forensic Medicine, Epidemiology, and Oncology.

Their work encompasses several main research topics, including Genetic Associations and Epidemiology, Genetic factors in colorectal cancer, Lymphoma Diagnosis and Treatment, Bioinformatics and Genomic Networks, Cancer Genomics and Diagnostics, Colorectal Cancer Screening and Detection, and Atherosclerosis and Cardiovascular Diseases.

Loeffler's published papers cover a variety of significant studies. Notable recent papers include:

  • Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression, 2021, Nature Genetics
  • Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour, 2021, Nature Human Behaviour
  • Framework and baseline examination of the German National Cohort (NAKO), 2022, European Journal of Epidemiology
  • Theranostic AGuIX nanoparticles as radiosensitizer: A phase I, dose-escalation study in patients with multiple brain metastases (NANO-RAD trial), 2021, Radiotherapy and Oncology
  • Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults, 2020, Nature Communications

Frequent co-authors collaborating with Loeffler throughout their career include Markus Scholz, Christoph Engel, Kerstin Wirkner, Holger Kirsten, and Arno Villringer.

Their research has been published repeatedly in a selection of academic venues, reflecting an active engagement with multiple journals. These venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • PLoS ONE
  • Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz
  • Nature Communications
  • Zenodo (CERN European Organization for Nuclear Research)

Best Publications

  • Intensive insulin therapy and pentastarch resuscitation in severe sepsis.

    Frank M. Brunkhorst;Christoph Engel;Frank Bloos;Andreas Meier-Hellmann

  • CHOP-like chemotherapy plus rituximab versus CHOP-like chemotherapy alone in young patients with good-prognosis diffuse large-B-cell lymphoma: a randomised controlled trial by the MabThera International Trial (MInT) Group

    Michael Pfreundschuh;Lorenz Trümper;Anders Österborg;Ruth Pettengell

  • Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt.

    Christopher S Potten;M Loeffler

  • Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

    Urmo Võsa;Annique Claringbould;Annique Claringbould;Harm-Jan Westra;Marc Jan Bonder

  • Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes

    Bjoern Chapuy;Chip Stewart;Andrew J Dunford;Jaegil Kim

  • Six versus eight cycles of bi-weekly CHOP-14 with or without rituximab in elderly patients with aggressive CD20+ B-cell lymphomas: a randomised controlled trial (RICOVER-60)

    Michael Pfreundschuh;Joerg Schubert;Marita Ziepert;Rudolf Schmits

  • A Biologic Definition of Burkitt's Lymphoma from Transcriptional and Genomic Profiling

    Michael Hummel;Stefan Bentink;Hilmar Berger;Wolfram Klapper

  • Standard and Increased-Dose BEACOPP Chemotherapy Compared with COPP-ABVD for Advanced Hodgkin's Disease

    Volker Diehl;Jeremy Franklin;Michael Pfreundschuh;Bernd Lathan

  • Epidemiology of sepsis in Germany: results from a national prospective multicenter study

    Christoph Engel;Frank M. Brunkhorst;Hans-Georg Bone;Reinhard Brunkhorst

  • Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: Implications for classification of gliomas

    Christian Hartmann;Christian Hartmann;Bettina Hentschel;Wolfgang Wick;Wolfgang Wick;David Capper

  • CHOP-like chemotherapy with or without rituximab in young patients with good-prognosis diffuse large-B-cell lymphoma: 6-year results of an open-label randomised study of the MabThera International Trial (MInT) Group.

    Michael Pfreundschuh;Evelyn Kuhnt;Lorenz Trümper;Anders Österborg

  • Two-weekly or 3-weekly CHOP chemotherapy with or without etoposide for the treatment of elderly patients with aggressive lymphomas: results of the NHL-B2 trial of the DSHNHL

    Michael Pfreundschuh;Lorenz Trümper;Marita Kloess;Rudolf Schmits

  • Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

    Richard Karlsson Linnér;Richard Karlsson Linnér;Pietro Biroli;Edward Kong;S. Fleur W. Meddens;S. Fleur W. Meddens

  • Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake

    Markus Loeffler;Jörg A. Krüger;Andreas G. Niethammer;Ralph A. Reisfeld

  • Molecular Predictors of Progression-Free and Overall Survival in Patients With Newly Diagnosed Glioblastoma: A Prospective Translational Study of the German Glioma Network

    Michael Weller;Jörg Felsberg;Christian Hartmann;Hilmar Berger

  • Standard International Prognostic Index Remains a Valid Predictor of Outcome for Patients With Aggressive CD20+ B-Cell Lymphoma in the Rituximab Era

    Marita Ziepert;Dirk Hasenclever;Evelyn Kuhnt;Bertram Glass

  • Treatment and prognosis of mature T-cell and NK-cell lymphoma: an analysis of patients with T-cell lymphoma treated in studies of the German High-Grade Non-Hodgkin Lymphoma Study Group.

    Norbert Schmitz;Lorenz Trümper;Marita Ziepert;Maike Nickelsen

  • Two-weekly or 3-weekly CHOP chemotherapy with or without etoposide for the treatment of young patients with good-prognosis (normal LDH) aggressive lymphomas: results of the NHL-B1 trial of the DSHNHL.

    Michael Pfreundschuh;Lorenz Trümper;Marita Kloess;Rudolf Schmits

  • MYC status in concert with BCL2 and BCL6 expression predicts outcome in diffuse large B-cell lymphoma

    Heike Horn;Marita Ziepert;Claudia Becher;Thomas F. E. Barth

  • NAD(P)H Oxidase and Multidrug Resistance Protein Genetic Polymorphisms Are Associated With Doxorubicin-Induced Cardiotoxicity

    Leszek Wojnowski;Bettina Kulle;Markus Schirmer;Gregor Schlüter

Frequent Co-Authors

Christoph Engel
Christoph Engel Leipzig University
Michael Pfreundschuh
Michael Pfreundschuh Saarland University
Arno Villringer
Arno Villringer Max Planck Institute for Human Cognitive and Brain Sciences
Lorenz Trümper
Lorenz Trümper University of Göttingen
Norbert Schmitz
Norbert Schmitz University of Münster
Joachim Thiery
Joachim Thiery Leipzig University
Andreas Rosenwald
Andreas Rosenwald University of Würzburg
A. Veronica Witte
A. Veronica Witte Max Planck Society
Wolfram Klapper
Wolfram Klapper Kiel University
Reiner Siebert
Reiner Siebert University of Ulm

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