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Marc D. Grynpas

Marc D. Grynpas

D-Index & Metrics

Medicine

D-Index
80
Citations
19795
World Ranking
17272
National Ranking
723

Overview

Marc D. Grynpas is affiliated with the University of Toronto in Canada and specializes in the field of medicine. Their research predominantly focuses on bone health, bone tissue engineering materials, and osteoarthritis treatment and mechanisms. The scope of their work includes topics such as bone metabolism and diseases, dental implant techniques and outcomes, orthopaedic implants, arthroplasty, as well as bone health and osteoporosis research.

Several recent papers illustrate the variety and direction of their research:

  • B cell acute lymphoblastic leukemia cells mediate RANK-RANKL-dependent bone destruction (2020, Science Translational Medicine)
  • Achieving enhanced bone regeneration using monetite granules with bone anabolic drug conjugates (C3 and C6) in rat mandibular defects (2020, Journal of Biomedical Materials Research Part B Applied Biomaterials)
  • Chlorthalidone with potassium citrate decreases calcium oxalate stones and increases bone quality in genetic hypercalciuric stone-forming rats (2021, Kidney International)
  • Fluoride effects on bone formation and mineralization are influenced by genetics (2020, UNC Libraries)
  • Phenotypic Variation of Fluoride Responses between Inbred Strains of Mice (2020, UNC Libraries)

Grynpas has collaborated frequently with several researchers, such as Adele Changoor, R. Peter Suderman, Paul R.T. Kuzyk, Jane Mitchell, and Kathy K. Lee. These co-authors have contributed to multiple projects and publications, supporting a broad, interdisciplinary approach to their research.

Their work has been published in a variety of scientific journals, reflecting the diversity of their research interests and collaborations. Frequent publication venues include the Journal of Orthopaedic Research®, UNC Libraries, Science Translational Medicine, Journal of Biomedical Materials Research Part B Applied Biomaterials, and Kidney International.

Their research subfields span oncology, genetics, surgery, rheumatology, and molecular biology, integrating these disciplines with their focus on bone-related health and treatments. This multilevel engagement with different aspects of medicine and biology highlights the complex nature of their investigations into bone disease, regeneration, and treatment mechanisms.

Through their research, Grynpas has contributed to advancing the understanding of bone health and associated medical conditions. Their work encompasses experimental studies on bone regeneration, metabolic effects on bone quality, and genetic influences on bone mineralization.

Best Publications

  • Hydroxyapatite reinforced polyethylene--a mechanically compatible implant material for bone replacement.

    W Bonfield;M.D Grynpas;A.E Tully;J Bowman

  • Randall’s plaque of patients with nephrolithiasis begins in basement membranes of thin loops of Henle

    Andrew P. Evan;James E. Lingeman;Fredric L. Coe;Joan H. Parks

  • Porous calcium polyphosphate scaffolds for bone substitute applications -- in vitro characterization.

    R.M Pilliar;M.J Filiaggi;J.D Wells;M.D Grynpas

  • Natural graft tissues and synthetic biomaterials for periodontal and alveolar bone reconstructive applications: a review

    Zeeshan Sheikh;Zeeshan Sheikh;Nader Hamdan;Yuichi Ikeda;Yuichi Ikeda;Marc Grynpas

  • Subchondral bone in osteoarthritis

    M. D. Grynpas;B. Alpert;I. Katz;I. Lieberman

  • Vanadium and diabetes

    Patrick Poucheret;Subodh Verma;Marc D. Grynpas;John H. McNeill

  • Macrophages promote osteoblastic differentiation in-vivo: implications in fracture repair and bone homeostasis.

    Linda Vi;Linda Vi;Gurpreet S Baht;Heather Whetstone;Adeline Ng;Adeline Ng

  • Resorbable implant biomaterial made of condensed calcium phosphate particles

    Rita Kandel;Robert Pilliar;Marc Grynpas

  • Mesenchymal progenitor self-renewal deficiency leads to age-dependent osteoporosis in Sca-1/Ly-6A null mice

    Mortaza Bonyadi;Stephen D. Waldman;Danmei Liu;Jane E. Aubin

  • Age and disease-related changes in the mineral of bone.

    M. Grynpas

  • Strontium increases vertebral bone volume in rats at a low dose that does not induce detectable mineralization defect

    M.D. Grynpas;E. Hamilton;R. Cheung;Y. Tsouderos

  • Crystal-Associated Nephropathy in Patients With Brushite Nephrolithiasis

    A.P. Evan;J.E. Lingeman;F.L. Coe;Y. Shao

  • α2-HS Glycoprotein/Fetuin, a Transforming Growth Factor-β/Bone Morphogenetic Protein Antagonist, Regulates Postnatal Bone Growth and Remodeling

    Melanie Szweras;Melanie Szweras;Danmei Liu;Emily A. Partridge;Judy Pawling

  • A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia

    Ann M. Flenniken;Lucy R. Osborne;Lucy R. Osborne;Nicole Anderson;Nadia Ciliberti

  • Long-term intermittent shear deformation improves the quality of cartilaginous tissue formed in vitro.

    Stephen D. Waldman;Caroline G. Spiteri;Marc D. Grynpas;Marc D. Grynpas;Robert M. Pilliar

  • Repair of osteochondral defects with biphasic cartilage-calcium polyphosphate constructs in a sheep model.

    R A Kandel;R A Kandel;M Grynpas;M Grynpas;R Pilliar;J Lee

  • Porous calcium polyphosphate scaffolds for bone substitute applications in vivo studies

    M.D. Grynpas;R.M. Pilliar;R.A. Kandel;R. Renlund

  • Genetic Regulation of Cortical and Trabecular Bone Strength and Microstructure in Inbred Strains of Mice

    Charles H. Turner;Yeou-Fang Hsieh;Ralph Müller;Mary L. Bouxsein

  • Effects of low doses of strontium on bone quality and quantity in rats.

    M.D. Grynpas;P.J. Marie

  • X-ray diffraction studies of the crystallinity of bone mineral in newly synthesized and density fractionated bone

    L. C. Bonar;A. H. Roufosse;W. K. Sabine;M. D. Grynpas

Frequent Co-Authors

Robert M. Pilliar
Robert M. Pilliar University of Toronto
David A. Bushinsky
David A. Bushinsky University of Rochester
Michael Glogauer
Michael Glogauer University of Toronto
Fredric L. Coe
Fredric L. Coe University of Chicago
Robert Rottapel
Robert Rottapel University of Toronto
Jean-Pierre Devogelaer
Jean-Pierre Devogelaer Université Catholique de Louvain
Andrew P. Evan
Andrew P. Evan Indiana University – Purdue University Indianapolis
William Bonfield
William Bonfield University of Cambridge
Melvin J. Glimcher
Melvin J. Glimcher Harvard University
James E. Lingeman
James E. Lingeman Indiana University

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