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Leonidas G. Koniaris

Leonidas G. Koniaris

Overview

Leonidas G. Koniaris is affiliated with Indiana University in the United States and has contributed extensively to the field of medicine, focusing primarily on oncology, pulmonary and respiratory medicine, epidemiology, physiology, and rheumatology. Their research encompasses several specialized topics, including nutrition and health in aging, pancreatic and hepatic oncology research, GDF15 and related biomarkers, thermal regulation in medicine, vitamin C and antioxidants research, TGF-β signaling in diseases, and renal cell carcinoma treatment.

The scientist has a significant record of recent publications, which include:

  • The impact of inflammation and acute phase activation in cancer cachexia, 2023, Frontiers in Immunology
  • The Combination of Low Skeletal Muscle Mass and High Tumor Interleukin-6 Associates with Decreased Survival in Clear Cell Renal Cell Carcinoma, 2020, Cancers
  • Pathological Responses of Cardiac Mitochondria to Burn Trauma, 2020, International Journal of Molecular Sciences
  • Profiling of Matched Adipose and Skeletal Muscle in Human Pancreatic Cancer Cachexia Reveals Distinct Gene Profiles with Convergent Pathways, 2021, Preprints.org
  • Randomized Phase II Study of Nab-Paclitaxel and Gemcitabine With or Without Tocilizumab as First-Line Treatment in Advanced Pancreatic Cancer: Survival and Cachexia, 2025, Journal of Clinical Oncology

Frequent co-authors of Leonidas G. Koniaris include Teresa A. Zimmers, Tyler P. Robinson, Denis C. Guttridge, Michael C. Ostrowski, and Yunlong Liu. These collaborations have contributed to the breadth of research topics covered and the diversity of publication venues.

The publication venues where their work commonly appears include:

  • Journal of Clinical Oncology
  • Cancers
  • Frontiers in Immunology
  • International Journal of Molecular Sciences
  • Preprints.org

Their research primarily falls under the broad field of Medicine, with 29 publications contributing to various intersections within this area. Subfields such as oncology, pulmonary and respiratory medicine, epidemiology, physiology, and rheumatology feature prominently in their work, reflecting a multidisciplinary approach to health and disease.

Best Publications

  • Resected adenocarcinoma of the pancreas— 616 patients: Results, outcomes, and prognostic indicators

    Taylor A. Sohn;Charles J. Yeo;John L. Cameron;Leonidas Koniaris

  • Induction of cachexia in mice by systemically administered myostatin

    Teresa A. Zimmers;Monique V. Davies;Leonidas G. Koniaris;Paul Haynes

  • Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes

    Joseph J. Senn;Peter J. Klover;Irena A. Nowak;Teresa A. Zimmers

  • Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice.

    Peter J. Klover;Teresa A. Zimmers;Leonidas G. Koniaris;Robert A. Mooney

  • Pediatric thyroid carcinoma: incidence and outcomes in 1753 patients.

    Anthony R. Hogan;Ying Zhuge;Eduardo A. Perez;Leonidas G. Koniaris

  • Human Mig chemokine: biochemical and functional characterization.

    Fang Liao;Ronald L. Rabin;John R. Yannelli;Leonidas G. Koniaris

  • JAK/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia

    Andrea Bonetto;Tufan Aydogdu;Xiaoling Jin;Xiaoling Jin;Zongxiu Zhang;Zongxiu Zhang

  • Chondrosarcoma in the United States (1973 to 2003): An Analysis of 2890 Cases from the SEER Database

    Angela Ylenia Giuffrida;Jorge E. Burgueno;Leonidas G. Koniaris;Juan C. Gutierrez

  • STAT3 Activation in Skeletal Muscle Links Muscle Wasting and the Acute Phase Response in Cancer Cachexia

    Andrea Bonetto;Tufan Aydogdu;Noelia Kunzevitzky;Denis C. Guttridge

  • Inflammatory myofibroblastic tumors

    Stephen J. Kovach;Anne C. Fischer;Philip J. Katzman;Rabih M. Salloum

  • Characterization of Growth-Differentiation Factor 15, a Transforming Growth Factor β Superfamily Member Induced following Liver Injury

    Edward C. Hsiao;Leonidas G. Koniaris;Teresa Zimmers-Koniaris;Suzanne M. Sebald

  • Acute inhibition of myostatin-family proteins preserves skeletal muscle in mouse models of cancer cachexia.

    Margaret E. Benny Klimek;Tufan Aydogdu;Majik J. Link;Marianne Pons

  • Should soft tissue sarcomas be treated at high-volume centers? An analysis of 4205 patients.

    Juan C. Gutierrez;Eduardo A. Perez;Frederick L. Moffat;Alan S. Livingstone

  • Interferon-inducible protein-10 identified as a mediator of tumor necrosis in vivo

    Cecilia Sgadari;Anne L. Angiolillo;Barry W. Cherney;Sandra E. Pike

  • Ewing sarcoma demonstrates racial disparities in incidence-related and sex-related differences in outcome: An analysis of 1631 cases from the SEER database, 1973-2005

    Muhammad U. Jawad;Michael C. Cheung;Elijah S. Min;Michaela M. Schneiderbauer

  • Growth differentiation factor-15/macrophage inhibitory cytokine-1 induction after kidney and lung injury.

    Teresa A. Zimmers;Xiaoling Jin;Edward C. Hsiao;Sharon A. McGrath

  • African American and poor patients have a dramatically worse prognosis for head and neck cancer: an examination of 20,915 patients.

    Manuel A. Molina;Michael C. Cheung;Eduardo A. Perez;Margaret M. Byrne

  • Current incidence and outcomes of gastrointestinal mesenchymal tumors including gastrointestinal stromal tumors.

    Eduardo A. Perez;Alan S. Livingstone;Dido Franceschi;Caio Rocha-Lima

  • Outcomes for soft-tissue sarcoma in 8249 cases from a large state cancer registry.

    Juan C. Gutierrez;Eduardo A. Perez;Dido Franceschi;Frederick L. Moffat

  • Paradoxical effects of short- and long-term interleukin-6 exposure on liver injury and repair.

    Xiaoling Jin;Teresa A. Zimmers;Eduardo A. Perez;Robert H. Pierce

Frequent Co-Authors

Charles J. Yeo
Charles J. Yeo Thomas Jefferson University
Yunlong Liu
Yunlong Liu Indiana University
Keith D. Lillemoe
Keith D. Lillemoe Harvard University
Timothy M. Pawlik
Timothy M. Pawlik The Ohio State University Wexner Medical Center
Michael P. Murphy
Michael P. Murphy University of Cambridge
Louis R. Kavoussi
Louis R. Kavoussi Northwell Health
Herbert Chen
Herbert Chen University of Alabama at Birmingham
Stephen B. Solomon
Stephen B. Solomon Memorial Sloan Kettering Cancer Center
Ralph H. Hruban
Ralph H. Hruban Johns Hopkins University School of Medicine
Joshua M. Farber
Joshua M. Farber National Institutes of Health

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