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Immunology

D-Index
62
Citations
16787
World Ranking
3109
National Ranking
1456

Overview

James M. Binley is a researcher affiliated with the Aaron Diamond AIDS Research Center in the United States. Their work primarily focuses on the fields of Immunology and Microbiology as well as Biochemistry, Genetics and Molecular Biology, with significant contributions to subfields such as Virology, Molecular Biology, Radiology, Nuclear Medicine and Imaging, Immunology, and Organic Chemistry.

The main topics covered in Binley's research include:

  • HIV Research and Treatment
  • Glycosylation and Glycoproteins Research
  • Monoclonal and Polyclonal Antibodies Research
  • RNA Interference and Gene Delivery
  • Immunotherapy and Immune Responses
  • Carbohydrate Chemistry and Synthesis
  • Bacteriophages and Microbial Interactions

Notable recent publications by Binley include:

  • Engineering well-expressed, V2-immunofocusing HIV-1 envelope glycoprotein membrane trimers for use in heterologous prime-boost vaccine regimens, 2021, PLoS Pathogens
  • Intramolecular quality control: HIV-1 envelope gp160 signal-peptide cleavage as a functional folding checkpoint, 2021, Cell Reports
  • Impact of stabilizing mutations on the antigenic profile and glycosylation of membrane-expressed HIV-1 envelope glycoprotein, 2023, PLoS Pathogens
  • A multidonor class of highly glycan-dependent HIV-1 gp120-gp41 interface-targeting broadly neutralizing antibodies, 2024, Cell Reports
  • Engineering well-expressed, V2-immunofocusing HIV-1 envelope glycoprotein membrane trimers for use in heterologous prime-boost vaccine regimens, 2021, bioRxiv (Cold Spring Harbor Laboratory)

Frequent co-authors who have collaborated with Binley include Alessio D'Addabbo, Max Crispin, Keiko Osawa, Tommy Tong, and Emma T. Crooks. These collaborations have contributed to a substantial body of research involving HIV envelope glycoproteins and antibody responses.

Binley's publications are frequently found in venues including bioRxiv (Cold Spring Harbor Laboratory), PLoS Pathogens, Cell Reports, Glycobiology, and AIDS Research and Human Retroviruses. The range of publication venues reflects the interdisciplinary nature of their research interests, spanning molecular biology techniques and immunological studies related to HIV.

Best Publications

  • CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5.

    Alexandra Trkola;Tatjana Dragic;James Arthos;James M. Binley

  • Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41.

    Michael B. Zwick;Aran F. Labrijn;Meng Wang;Catherine Spenlehauer

  • Comprehensive Cross-Clade Neutralization Analysis of a Panel of Anti-Human Immunodeficiency Virus Type 1 Monoclonal Antibodies

    James M. Binley;Terri Wrin;Bette Korber;Michael B. Zwick

  • A Recombinant Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Complex Stabilized by an Intermolecular Disulfide Bond between the gp120 and gp41 Subunits Is an Antigenic Mimic of the Trimeric Virion-Associated Structure

    James M. Binley;Rogier W. Sanders;Brian Clas;Norbert Schuelke

  • Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies.

    Nicole A. Doria-Rose;Chaim A. Schramm;Jason Gorman;Penny L. Moore

  • Rapid production and clearance of HIV-1 and hepatitis C virus assessed by large volume plasma apheresis

    Bharat Ramratnam;Sebastian Bonhoeffer;James Binley;Arlene Hurley

  • Broadly Neutralizing Anti-HIV Antibody 4E10 Recognizes a Helical Conformation of a Highly Conserved Fusion-Associated Motif in gp41

    Rosa M.F. Cardoso;Michael B. Zwick;Robyn L. Stanfield;Renate Kunert

  • Broad and potent HIV-1 neutralization by a human antibody that binds the gp41–gp120 interface

    Jinghe Huang;Byong H. Kang;Marie Pancera;Jeong Hyun Lee

  • Access of Antibody Molecules to the Conserved Coreceptor Binding Site on Glycoprotein gp120 Is Sterically Restricted on Primary Human Immunodeficiency Virus Type 1

    Aran F. Labrijn;Pascal Poignard;Aarti Raja;Michael B. Zwick

  • Nature of nonfunctional envelope proteins on the surface of human immunodeficiency virus type 1.

    Penny L. Moore;Emma T. Crooks;Lauren Porter;Ping Zhu

  • Profiling the Specificity of Neutralizing Antibodies in a Large Panel of Plasmas from Patients Chronically Infected with Human Immunodeficiency Virus Type 1 Subtypes B and C

    James M. Binley;Elizabeth A. Lybarger;Emma T. Crooks;Michael S. Seaman

  • Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

    Young Do Kwon;Marie Pancera;Priyamvada Acharya;Ivelin S. Georgiev

  • Neutralization of the human immunodeficiency virus type 1 primary isolate JR-FL by human monoclonal antibodies correlates with antibody binding to the oligomeric form of the envelope glycoprotein complex.

    T R Fouts;J M Binley;A Trkola;J E Robinson

  • Molecular profile of an antibody response to HIV-1 as probed by combinatorial libraries

    Carlos F. Barbas;Thomas A. Collet;Willi Amberg;Paul Roben

  • Broadly cross-reactive HIV-1-neutralizing human monoclonal Fab selected for binding to gp120–CD4–CCR5 complexes

    Maxime Moulard;Sanjay K. Phogat;Yuuei Shu;Aran F. Labrijn

  • HIV-1 Antigen–specific and –nonspecific B Cell Responses Are Sensitive to Combination Antiretroviral Therapy

    Lynn Morris;James M. Binley;Brian A. Clas;Sebastian Bonhoeffer

  • HIV-1–specific immune responses in subjects who temporarily contain virus replication after discontinuation of highly active antiretroviral therapy

    Gabriel M. Ortiz;Douglas F. Nixon;Alexandra Trkola;James Binley

  • An Affinity-Enhanced Neutralizing Antibody against the Membrane-Proximal External Region of Human Immunodeficiency Virus Type 1 gp41 Recognizes an Epitope between Those of 2F5 and 4E10

    Josh D. Nelson;Florence M. Brunel;Richard Jensen;Emma T. Crooks

  • Fine Definition of the Epitope on the gp41 Glycoprotein of Human Immunodeficiency Virus Type 1 for the Neutralizing Monoclonal Antibody 2F5

    Carol E. Parker;Leesa J. Deterding;Christine Hager-Braun;James M. Binley

  • Polyclonal B Cell Responses to Conserved Neutralization Epitopes in a Subset of HIV-1-Infected Individuals

    Georgia D. Tomaras;James M. Binley;Elin S. Gray;Emma T. Crooks

Frequent Co-Authors

John P. Moore
John P. Moore Cornell University
Dennis R. Burton
Dennis R. Burton Scripps Research Institute
David C. Montefiori
David C. Montefiori Duke University
Rogier W. Sanders
Rogier W. Sanders University of Amsterdam
John R. Mascola
John R. Mascola ModeX Therapeutics
Richard T. Wyatt
Richard T. Wyatt Scripps Research Institute
William R. Schief
William R. Schief Scripps Research Institute
Lynn Morris
Lynn Morris University of the Witwatersrand
Paul W. H. I. Parren
Paul W. H. I. Parren Leiden University Medical Center
William C. Olson
William C. Olson Regeneron (United States)

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