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James L. Abbruzzese

James L. Abbruzzese

D-Index & Metrics

Medicine

D-Index
147
Citations
76825
World Ranking
1295
National Ranking
747

Overview

James L. Abbruzzese is affiliated with Duke University in the United States and has a significant body of work in the fields of medicine and biochemistry, genetics, and molecular biology. Their research primarily focuses on oncology, with substantial contributions to pancreatic and hepatic oncology, cancer genomics and diagnostics, as well as cancer immunotherapy and biomarkers.

Their main fields of study include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

They have focused on several subfields, notably:

  • Oncology
  • Molecular Biology
  • Immunology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

Key research topics covered in their publications involve:

  • Pancreatic and Hepatic Oncology Research
  • Phagocytosis and Immune Regulation
  • Cancer Genomics and Diagnostics
  • Cancer Immunotherapy and Biomarkers
  • Lung Cancer Treatments and Mutations
  • PARP inhibition in cancer therapy
  • Ovarian cancer diagnosis and treatment

Their recent papers include:

  • Durvalumab plus tremelimumab alone or in combination with low-dose or hypofractionated radiotherapy in metastatic non-small-cell lung cancer refractory to previous PD(L)-1 therapy: an open-label, multicentre, randomised, phase 2 trial, 2022, The Lancet Oncology
  • Implementation of a Molecular Tumor Registry to Support the Adoption of Precision Oncology Within an Academic Medical Center: The Duke University Experience, 2021, JCO Precision Oncology
  • Genetic variants of the peroxisome proliferator-activated receptor (PPAR) signaling pathway genes and risk of pancreatic cancer, 2020, Molecular Carcinogenesis
  • Selective killing of cancer cells harboring mutant RAS by concomitant inhibition of NADPH oxidase and glutathione biosynthesis, 2021, Cell Death and Disease
  • Abstract CT145: Olaparib +/- atezolizumab in patients with BRCA-mutated (BRCAmt) locally advanced unresectable or metastatic (advanced) breast cancer: an open-label, multicenter, randomized phase II trial, 2023, Cancer Research

Frequent co-authors in their research include:

  • S. Percy Ivy
  • Elad Sharon
  • Mark M. Awad
  • John H. Strickler
  • Yongde Luo

Their work has frequently been published in journals such as:

  • Journal of Clinical Oncology
  • Cancer Research
  • Gynecologic Oncology
  • Cancers
  • The Lancet Oncology

Best Publications

  • The Effect of Celecoxib, a Cyclooxygenase-2 Inhibitor, in Familial Adenomatous Polyposis

    Gideon Steinbach;Patrick M. Lynch;Robin K S Phillips;Marina H. Wallace

  • Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer

    Navneet Dhillon;Bharat B. Aggarwal;Robert A. Newman;Robert A. Wolff

  • Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma

    Mark J. Ratain;Tim Eisen;Walter M. Stadler;Keith T. Flaherty

  • Epithelial to Mesenchymal Transition Contributes to Drug Resistance in Pancreatic Cancer

    Thiruvengadam Arumugam;Vijaya Ramachandran;Keith Francis Fournier;Huamin Wang

  • Borderline Resectable Pancreatic Cancer: Definitions, Management, and Role of Preoperative Therapy

    Gauri R. Varadhachary;Eric P. Tamm;James L. Abbruzzese;Henry Q. Xiong

  • A phase I clinical, plasma, and cellular pharmacology study of gemcitabine.

    J L Abbruzzese;R Grunewald;E A Weeks;D Gravel

  • Risk factors for hepatocellular carcinoma: Synergism of alcohol with viral hepatitis and diabetes mellitus

    Manal M. Hassan;Lu Yu Hwang;Chiq J. Hatten;Mark Swaim

  • The Nuclear Factor-κB RelA Transcription Factor Is Constitutively Activated in Human Pancreatic Adenocarcinoma Cells

    Weixin Wang;James L. Abbruzzese;Douglas B. Evans;Lillie Larry

  • Metastatic patterns in adenocarcinoma

    Kenneth R. Hess;Gauri R. Varadhachary;Sarah H. Taylor;Wei Wei

  • Epidermal Growth Factor Receptor Cooperates with Signal Transducer and Activator of Transcription 3 to Induce Epithelial-Mesenchymal Transition in Cancer Cells via Up-regulation of TWIST Gene Expression

    Hui Wen Lo;Sheng Chieh Hsu;Weiya Xia;Xinyu Cao

  • Preoperative Gemcitabine-Based Chemoradiation for Patients With Resectable Adenocarcinoma of the Pancreatic Head

    Douglas B. Evans;Gauri R. Varadhachary;Christopher H. Crane;Charlotte C. Sun

  • Phase III Study Comparing Gemcitabine Plus Cetuximab Versus Gemcitabine in Patients With Advanced Pancreatic Adenocarcinoma: Southwest Oncology Group–Directed Intergroup Trial S0205

    Philip A. Philip;Jacqueline Benedetti;Christopher L. Corless;Ralph Wong

  • Antidiabetic therapies affect risk of pancreatic cancer

    Donghui Li;Sai–Ching J. Yeung;Manal M. Hassan;Marina Konopleva

  • Acquisition of Epithelial-Mesenchymal Transition Phenotype of Gemcitabine-Resistant Pancreatic Cancer Cells Is Linked with Activation of the Notch Signaling Pathway

    Zhiwei Wang;Yiwei Li;Dejuan Kong;Sanjeev Banerjee

  • Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis

    Daoyan Wei;Xiangdong Le;Leizhen Zheng;Liwei Wang

  • Blockade of the Epidermal Growth Factor Receptor Signaling by a Novel Tyrosine Kinase Inhibitor Leads to Apoptosis of Endothelial Cells and Therapy of Human Pancreatic Carcinoma

    Christiane J. Bruns;Carmen C. Solorzano;Matthew T. Harbison;Shutaro Ozawa

  • Cetuximab, a Monoclonal Antibody Targeting the Epidermal Growth Factor Receptor, in Combination With Gemcitabine for Advanced Pancreatic Cancer: A Multicenter Phase II Trial

    Henry Q. Xiong;Arthur Rosenberg;Albert LoBuglio;William Schmidt

  • Preoperative and postoperative chemoradiation strategies in patients treated with pancreaticoduodenectomy for adenocarcinoma of the pancreas.

    F. R. Spitz;J. L. Abbruzzese;Jeffrey E Lee;Peter W Pisters

  • A Phase I/II Trial of Intratumoral Endoscopic Ultrasound Injection of ONYX-015 with Intravenous Gemcitabine in Unresectable Pancreatic Carcinoma

    J Randolph Hecht;Rudolph Bedford;James L Abbruzzese;Sandeep Lahoti

  • Body Mass Index and Risk, Age of Onset, and Survival in Patients With Pancreatic Cancer

    Donghui Li;Jeffrey S. Morris;Jun Liu;Manal M. Hassan

Frequent Co-Authors

Robert A. Wolff
Robert A. Wolff The University of Texas MD Anderson Cancer Center
Douglas B. Evans
Douglas B. Evans Medical College of Wisconsin
Huamin Wang
Huamin Wang The University of Texas MD Anderson Cancer Center
Jeffrey E. Lee
Jeffrey E. Lee The University of Texas MD Anderson Cancer Center
Peter W.T. Pisters
Peter W.T. Pisters The University of Texas MD Anderson Cancer Center
Christopher H. Crane
Christopher H. Crane Memorial Sloan Kettering Cancer Center
Jason B. Fleming
Jason B. Fleming The University of Texas MD Anderson Cancer Center
Michael J. Overman
Michael J. Overman The University of Texas MD Anderson Cancer Center
Kenneth R. Hess
Kenneth R. Hess The University of Texas MD Anderson Cancer Center
Jean Nicolas Vauthey
Jean Nicolas Vauthey The University of Texas MD Anderson Cancer Center

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