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Immunology

D-Index
66
Citations
18656
World Ranking
2734
National Ranking
1303

Overview

James A. Lederer is affiliated with Brigham and Women's Hospital in the United States and has a significant body of work primarily focused on medicine and immunology. Their research spans multiple related subfields including immunology, oncology, molecular biology, genetics, and pulmonary and respiratory medicine.

The scientist has contributed extensively to topics such as:

  • Immune cells in cancer
  • Immune Cell Function and Interaction
  • Systemic Lupus Erythematosus Research
  • Immune Response and Inflammation
  • T-cell and B-cell Immunology
  • Immunotherapy and Immune Responses
  • CAR-T cell therapy research

Published papers include:

  • Quick COVID-19 Healers Sustain Anti-SARS-CoV-2 Antibody Production, 2020, Cell
  • Immune phenotyping of diverse syngeneic murine brain tumors identifies immunologically distinct types, 2020, Nature Communications
  • cyCombine allows for robust integration of single-cell cytometry datasets within and across technologies, 2022, Nature Communications
  • Inflammasome activation in neutrophils of patients with severe COVID-19, 2022, Blood Advances
  • IL-1β-driven osteoclastogenic Tregs accelerate bone erosion in arthritis, 2021, Journal of Clinical Investigation

James A. Lederer's frequent co-authors include:

  • Joshua Keegan
  • Deepak A. Rao
  • A. Helena Jonsson
  • Alec Griffith
  • V. Michael Holers

The scientist's work has appeared in several notable publication venues with the highest number of contributions in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Journal of Clinical Investigation
  • Regular and Young Investigator Award Abstracts
  • Blood Advances

Their research has a strong emphasis on understanding immune mechanisms, examining immune cell behaviors in cancer and autoimmune diseases, and advancing immunotherapy techniques. The interdisciplinary nature of their studies integrates molecular biology and genetics within clinical contexts related to pulmonary and respiratory medicine.

Best Publications

  • A network-based analysis of systemic inflammation in humans

    Steve E. Calvano;Wenzhong Xiao;Daniel R. Richards;Ramon M. Felciano

  • Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry.

    Fan Zhang;Kevin Wei;Kamil Slowikowski;Chamith Y Fonseka

  • Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis

    Deepak A. Rao;Michael F. Gurish;Jennifer L. Marshall;Kamil Slowikowski

  • The immune cell landscape in kidneys of patients with lupus nephritis

    Arnon Arazi;Deepak A Rao;Celine C Berthier;Anne Davidson

  • Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity.

    Ellen Shrock;Ellen Shrock;Eric Fujimura;Eric Fujimura;Tomasz Kula;Tomasz Kula;Richard T. Timms;Richard T. Timms

  • Major injury leads to predominance of the T helper-2 lymphocyte phenotype and diminished interleukin-12 production associated with decreased resistance to infection.

    S T O'Sullivan;J A Lederer;A F Horgan;D H Chin

  • Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis

    Fumitaka Mizoguchi;Kamil Slowikowski;Kevin Wei;Jennifer L. Marshall

  • THE EFFECTS OF INJURY ON THE ADAPTIVE IMMUNE RESPONSE

    James A. Lederer;Mary L. Rodrick;John A. Mannick

  • Injury Primes the Innate Immune System for Enhanced Toll-Like Receptor Reactivity

    Hugh M. Paterson;Thomas J. Murphy;Elizabeth J. Purcell;Odhran Shelley

  • The immunologic response to injury.

    John A Mannick;Mary L Rodrick;James A Lederer

  • Major Injury Leads to Predominance of the T Helper‐2 Lymphocyte Phenotype and Diminished Interleukin‐12 Production Associated with Decreased Resistance to Infection

    Unknown

  • Major Injury Induces Increased Production of Interleukin-10 by Cells of the Immune System With a Negative Impact on Resistance to Infection

    Ann Lyons;John L. Kelly;Mary L. Rodrick;John A. Mannick

  • Impairment of the Programmed Cell Death-1 Pathway Increases Atherosclerotic Lesion Development and Inflammation

    De-xiu Bu;Margarite Tarrio;Elena Maganto-Garcia;George Stavrakis

  • PD-1hiCXCR5– T peripheral helper cells promote B cell responses in lupus via MAF and IL-21

    Alexandra V. Bocharnikov;Joshua Keegan;Vanessa S. Wacleche;Ye Cao

  • Circadian rhythm reprogramming during lung inflammation

    Jeffrey A Haspel;Sukrutha Chettimada;Rahamthulla S Shaik;Jen-Hwa Chu

  • Impaired Regulatory T-Cell Response and Enhanced Atherosclerosis in the Absence of Inducible Costimulatory Molecule

    Israel Gotsman;Nir Grabie;Rajat Gupta;Rosa Dacosta

  • CD4+CD25+ Regulatory T Cells Control Innate Immune Reactivity after Injury

    Thomas J. Murphy;Niamh Ni Choileain;Yan Zang;John A. Mannick

  • Differentiation of the T helper phenotypes by analysis of the methylation state of the IFN-gamma gene.

    H A Young;P Ghosh;J Ye;J Lederer

  • Targeting Regulatory T Cells in Cancer

    William L. Byrne;Kingston H.G. Mills;James A. Lederer;Gerald C. O'Sullivan

  • Cytokine transcriptional events during helper T cell subset differentiation

    James A. Lederer;Victor L. Perez;Lori DesRoches;So Mee Kim

  • STABILITY OF TH1 AND TH2 POPULATIONS

    Victor L. Perez;James A. Lederer;Andrew H. Lichtman;Abul K. Abbas

  • Quantitative Proteome Analysis of Human Plasma following in Vivo Lipopolysaccharide Administration Using 16O/18O Labeling and the Accurate Mass and Time Tag Approach

    Wei Jun Qian;Matthew E. Monroe;Tao Liu;Jon M. Jacobs

Frequent Co-Authors

John A. Mannick
John A. Mannick Brigham and Women's Hospital
Irshad H. Chaudry
Irshad H. Chaudry University of Alabama at Birmingham
Michael B. Brenner
Michael B. Brenner Harvard Medical School
Andrew H. Lichtman
Andrew H. Lichtman Brigham and Women's Hospital
Daniel G. Remick
Daniel G. Remick Boston University
Nir Hacohen
Nir Hacohen Harvard University
Henry V. Baker
Henry V. Baker University of Florida
Peter A. Nigrovic
Peter A. Nigrovic Boston Children's Hospital
Soumya Raychaudhuri
Soumya Raychaudhuri Brigham and Women's Hospital
Ronald W. Davis
Ronald W. Davis Stanford University

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Related Online Degrees & Career Pathways

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Choosing the right online degree depends on your career goals and the level of specialization desired. Each pathway offers unique benefits, making it easier than ever to integrate immunology into a versatile healthcare profession.

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