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Immunology

D-Index
45
Citations
20686
World Ranking
4656
National Ranking
2096

Overview

Deborah J. Lenschow is affiliated with Washington University in St. Louis in the United States. Their research primarily falls within the fields of Medicine and Immunology and Microbiology, with a focus on subfields such as Infectious Diseases, Immunology, Molecular Biology, Epidemiology, and Oncology.

The scientist's main research topics include interferon and immune responses, SARS-CoV-2 and COVID-19 research, mosquito-borne diseases and control, cytomegalovirus and herpesvirus research, COVID-19 clinical research studies, cytokine signaling pathways and interactions, and viral infections and vectors.

Notable recent papers by Deborah J. Lenschow include:

  • "Modulation of Extracellular ISG15 Signaling by Pathogens and Viral Effector Proteins" (2020, Cell Reports)
  • "ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells" (2020, mBio)
  • "6-Thioguanine blocks SARS-CoV-2 replication by inhibition of PLpro" (2021, iScience)
  • "6-Thioguanine blocks SARS-CoV-2 replication by inhibition of PLpro protease activities" (2020, bioRxiv (Cold Spring Harbor Laboratory))
  • "Initiator cell death event induced by SARS-CoV-2 in the human airway epithelium" (2024, Science Immunology)

Frequent co-authors working alongside Deborah J. Lenschow include Lindsey E. Fox, Kristen Monte, Marissa C. Locke, Yi-Chieh Perng, and Caleb D. Swaim.

The scientist has published in various venues, with multiple publications in bioRxiv (Cold Spring Harbor Laboratory) and The Journal of Immunology, as well as publications in Cell Reports, mBio, and iScience.

Best Publications

  • CD28/B7 SYSTEM OF T CELL COSTIMULATION

    Deborah J. Lenschow;Theresa L. Walunas;Jeffrey A. Bluestone

  • CTLA-4 can function as a negative regulator of T cell activation

    Theresa L. Walunas;Deborah J. Lenschow;Christina Y. Bakker;Peter S. Linsley

  • B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes.

    Benoît Salomon;Deborah J Lenschow;Lesley Rhee;Neda Ashourian

  • Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4lg

    DJ Lenschow;Y Zeng;Thistlethwaite;A Montag

  • Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse.

    Deborah J. Lenschow;Stephen C. Ho;I Husain Sattar;Lesley Rhee

  • Identification of a candidate therapeutic autophagy-inducing peptide

    Sanae Shoji-Kawata;Rhea Sumpter;Matthew J Leveno;Grant R. Campbell;Grant R. Campbell

  • IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses.

    Deborah J. Lenschow;Caroline Lai;Natalia Frias-Staheli;Nadia V. Giannakopoulos

  • The microbial metabolite desaminotyrosine protects from influenza through type I interferon

    Ashley L. Steed;George P. Christophi;Gerard E. Kaiko;Lulu Sun

  • Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen

    Felicity J Burt;Weiqiang Chen;Jonathan J Miner;Deborah J Lenschow

  • CD28/B7 Regulation of Th1 and Th2 Subsets in the Development of Autoimmune Diabetes

    Deborah J. Lenschow;Kevan C. Herold;Lesley Rhee;Bina Patel

  • Expression and functional significance of an additional ligand for CTLA-4.

    Deborah J. Lenschow;Gloria Huei-Ting Su;Linda A. Zuckerman;Nasrin Nabavi

  • Ovarian tumor domain-containing viral proteases evade ubiquitin- and ISG15-dependent innate immune responses.

    Natalia Frias-Staheli;Nadia V. Giannakopoulos;Marjolein Kikkert;Shannon L. Taylor

  • Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen.

    Deborah J. Lenschow;Anne I. Sperling;Michael P. Cooke;Gordon Freeman

  • Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE

    Stephen D. Miller;Carol L. Vanderlugt;Deborah J. Lenschow;Jonathan G. Pope

  • Identification of interferon-stimulated gene 15 as an antiviral molecule during sindbis virus infection in vivo

    Deborah J. Lenschow;Nadia V. Giannakopoulos;Lacey J. Gunn;Christine Johnston

  • Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.

    Nadia V. Giannakopoulos;Jiann Kae Luo;Vladimir Papov;Weiguo Zou

  • Chikungunya virus–induced autophagy delays caspase-dependent cell death

    Pierre Emmanuel Joubert;Pierre Emmanuel Joubert;Scott W. Werneke;Claire de la Calle;Florence Guivel-Benhassine

  • Inhibition of transplant rejection following treatment with anti-B7-2 and anti-B7-1 antibodies.

    D. J. Lenschow;Yijun Zeng;K. S. Hathcock;L. A. Zuckerman

  • ISG15 Is Critical in the Control of Chikungunya Virus Infection Independent of UbE1L Mediated Conjugation

    Scott W. Werneke;Clementine Schilte;Clementine Schilte;Anjali Rohatgi;Kristen J. Monte

  • ISG15 deficiency and increased viral resistance in humans but not mice.

    Scott D. Speer;Zhi Li;Sofija Buta;Béatrice Payelle-Brogard

  • Chikungunya viral arthritis in the United States: a mimic of seronegative rheumatoid arthritis.

    Jonathan J. Miner;Han Xian Aw Yeang;Julie M. Fox;Samantha Taffner

  • IL-4 treatment of small splenic B cells induces costimulatory molecules B7-1 and B7-2.

    R M Stack;D J Lenschow;G S Gray;J A Bluestone

Frequent Co-Authors

Jeffrey A. Bluestone
Jeffrey A. Bluestone University of California, San Francisco
Craig B. Thompson
Craig B. Thompson Memorial Sloan Kettering Cancer Center
Stephen D. Miller
Stephen D. Miller Northwestern University
Kevan C. Herold
Kevan C. Herold Yale University
Gordon J. Freeman
Gordon J. Freeman Harvard University
Mauro C. Dal Canto
Mauro C. Dal Canto Northwestern University
Peter S. Linsley
Peter S. Linsley Benaroya Research Institute
Gary S. Gray
Gary S. Gray Harvard University
Arlene H. Sharpe
Arlene H. Sharpe Harvard University
Elaine Fuchs
Elaine Fuchs Rockefeller University

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