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Molecular Biology

D-Index
47
Citations
12558
World Ranking
2716
National Ranking
1316

Research.com Recognitions

  • 2010 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Charles Barlowe is affiliated with Dartmouth College in the United States and contributes to the field of Biochemistry, Genetics and Molecular Biology. Their research primarily focuses on cell biology and molecular biology, with additional work related to immunology.

Their recent publications span multiple areas related to cellular transport, secretion, and protein processing within the secretory pathway. Notable papers include:

  • The secretory pathway gets a molecular framework, 2025, published in Nature Reviews Molecular Cell Biology
  • The Erv41-Erv46 complex serves as a retrograde receptor to retrieve misfolded secretory proteins that have escaped from the ER, 2025, published in Molecular Biology of the Cell
  • The C-terminus of the cargo receptor Erv14 affects COPII vesicle formation and cargo delivery, 2023, published in Journal of Cell Science
  • The C-terminus of the cargo receptor Erv14p affects COPII vesicle formation and cargo delivery, 2022, published in bioRxiv (Cold Spring Harbor Laboratory)

The scientist collaborates frequently with several researchers, including Daniel Lagunas-Gómez, Carolina Yáñez-Domínguez, Guadalupe Zavala-Padilla, Omar Pantoja, and John Fuesler. This collaboration reflects a network of expertise particularly around molecular mechanisms governing vesicle formation, cargo receptor function, and secretory pathway regulation.

Charles Barlowe's research intersects with key topics such as:

  • Cellular transport and secretion
  • Glycosylation and Glycoproteins Research
  • Signaling Pathways in Disease
  • Microtubule and mitosis dynamics
  • Endoplasmic Reticulum Stress and Disease
  • Phagocytosis and Immune Regulation

Their work has been published in venues including the Journal of Cell Science, bioRxiv (Cold Spring Harbor Laboratory), Molecular Biology of the Cell, and Nature Reviews Molecular Cell Biology.

In recognition of their contributions to science, Charles Barlowe was named a Fellow of the American Association for the Advancement of Science (AAAS) in 2010.

Best Publications

  • COPII: a membrane coat formed by Sec proteins that drive vesicle budding from the endoplasmic reticulum.

    Charles Barlowe;Lelio Orci;Tom Yeung;Midori Hosobuchi

  • SEC12 encodes a guanine-nucleotide-exchange factor essential for transport vesicle budding from the ER

    Charles Barlowe;Randy Schekman

  • The Parkinson's disease protein α-synuclein disrupts cellular Rab homeostasis

    Aaron D. Gitler;Brooke J. Bevis;James Shorter;Katherine E. Strathearn

  • Organization of the ER–Golgi interface for membrane traffic control

    Federica Brandizzi;Charles Barlowe

  • Initial docking of ER‐derived vesicles requires Uso1p and Ypt1p but is independent of SNARE proteins

    Xiaochun Cao;Nicole Ballew;Charles Barlowe

  • Requirement for a GTPase-activating protein in vesicle budding from the endoplasmic reticulum.

    Tohru Yoshihisa;Charles Barlowe;Randy Schekman

  • The absence of Emp24p, a component of ER-derived COPII-coated vesicles, causes a defect in transport of selected proteins to the Golgi.

    F Schimmöller;B Singer-Krüger;S Schröder;U Krüger

  • Signals for COPII-dependent export from the ER: what's the ticket out?

    Charles Barlowe

  • Protein sorting receptors in the early secretory pathway.

    Julia Dancourt;Charles Barlowe

  • Secretory Protein Biogenesis and Traffic in the Early Secretory Pathway

    Charles K. Barlowe;Elizabeth A. Miller

  • Role of Erv29p in Collecting Soluble Secretory Proteins into ER-Derived Transport Vesicles

    William J. Belden;Charles Barlowe

  • Distinct retrieval and retention mechanisms are required for the quality control of endoplasmic reticulum protein folding

    Shilpa Vashist;Woong Kim;William J. Belden;Eric D. Spear

  • Erv25p, a Component of COPII-coated Vesicles, Forms a Complex with Emp24p That Is Required for Efficient Endoplasmic Reticulum to Golgi Transport

    William J. Belden;Charles Barlowe

  • Purification and characterization of SAR1p, a small GTP-binding protein required for transport vesicle formation from the endoplasmic reticulum.

    C Barlowe;C d'Enfert;R Schekman

  • Coupled ER to Golgi transport reconstituted with purified cytosolic proteins.

    Charles Barlowe

  • Transport of Axl2p Depends on Erv14p, an ER–Vesicle Protein Related to the Drosophila cornichon Gene Product

    Jacqueline Powers;Charles Barlowe

  • Asymmetric requirements for a Rab GTPase and SNARE proteins in fusion of COPII vesicles with acceptor membranes.

    Xiaochun Cao;Charles Barlowe

  • Cargo Capture and Bulk Flow in the Early Secretory Pathway

    Charles Barlowe;Ari Helenius

  • Analysis of Sec22p in endoplasmic reticulum/Golgi transport reveals cellular redundancy in SNARE protein function.

    Yiting Liu;Charles Barlowe

  • COPII and selective export from the endoplasmic reticulum

    Charles Barlowe

Frequent Co-Authors

Randy Schekman
Randy Schekman University of California, Berkeley
Federica Brandizzi
Federica Brandizzi Michigan State University
Aaron D. Gitler
Aaron D. Gitler Stanford University
Wanjin Hong
Wanjin Hong Agency for Science, Technology and Research
Joseph P. Albanesi
Joseph P. Albanesi The University of Texas Southwestern Medical Center
Lelio Orci
Lelio Orci University of Geneva
Paul Jenö
Paul Jenö University of Basel
Hugh R.B. Pelham
Hugh R.B. Pelham MRC Laboratory of Molecular Biology
Aurélien Roux
Aurélien Roux University of Geneva

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