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S. van Drunen Littel-van den Hurk

S. van Drunen Littel-van den Hurk

D-Index & Metrics

Microbiology

D-Index
57
Citations
9031
World Ranking
3637
National Ranking
107

Overview

S. van Drunen Littel-van den Hurk is affiliated with the University of Saskatchewan in Canada. Their research spans multiple disciplines within medicine and biochemistry, genetics, and molecular biology with a particular focus on epidemiology and molecular biology subfields.

Their recent scientific contributions include investigations into viral infections, vaccine development, and nanoparticle-mediated gene delivery. Key topics in their work encompass herpesvirus infections and treatments, cytomegalovirus and herpesvirus research, RNA interference and gene delivery, advanced biosensing and bioanalysis techniques, immunotherapy and immune responses, influenza virus research studies, and respiratory viral infections research.

Recent papers authored or co-authored by the scientist cover varied research areas and include:

  • Low molecular weight chitosan nanoparticles for CpG oligodeoxynucleotides delivery: Impact of molecular weight, degree of deacetylation, and mannosylation on intracellular uptake and cytokine induction (2020, International Journal of Biological Macromolecules)
  • Comprehensive Lipidomic and Metabolomic Analysis for Studying Metabolic Changes in Lung Tissue Induced by a Vaccine against Respiratory Syncytial Virus (2020, ACS Infectious Diseases)
  • Innate immunemodulator containing adjuvant formulated HA based vaccine protects mice from lethal infection of highly pathogenic avian influenza H5N1 virus (2020, Vaccine)
  • The biology and development of vaccines for bovine alphaherpesvirus 1 (2024, The Veterinary Journal)
  • Chitosan nanoparticles fabricated through host-guest interaction for enhancing the immunostimulatory effect of CpG oligodeoxynucleotide (2021, Carbohydrate Polymers)

The frequent venues for this scientist's publications include:

  • Viruses
  • International Journal of Biological Macromolecules
  • ACS Infectious Diseases
  • The Veterinary Journal
  • Vaccine

Collaborations are an integral part of their research, with frequent co-authors including Soumya Sucharita, Zhenggang Wang, Lingyun Chen, Akshaya Krishnagopal, and Oksana Babii.

Their multidisciplinary approach combines expertise in immunology, genetics, and molecular biology to address challenges in infectious diseases and vaccine technologies. This includes studying molecular mechanisms of viral pathogens, developing nanoparticle delivery systems, and analyzing immune responses relevant to vaccine efficacy and protection.

Best Publications

  • CpG motif identification for veterinary and laboratory species demonstrates that sequence recognition is highly conserved.

    Robert Rankin;Reno Pontarollo;Xenia Ioannou;Arthur M. Krieg

  • Induction of immune responses by DNA vaccines in large animals.

    L A Babiuk;R Pontarollo;S Babiuk;B Loehr

  • Immunology of bovine herpesvirus 1 infection.

    L.A. Babiuk;S. van Drunen Littel-van den Hurk;S.K. Tikoo

  • Protection of cattle from bovine herpesvirus type I (BHV-1) infection by immunization with individual viral glycoproteins.

    L.A. Babiuk;J. L'Italien;S. van Drunen Littel-van den Hurk;T. Zamb

  • Biological activity of immunostimulatory CpG DNA motifs in domestic animals.

    G Mutwiri;R Pontarollo;S Babiuk;P Griebel

  • Intradermal immunization with a bovine herpesvirus-1 DNA vaccine induces protective immunity in cattle

    S. Van Drunen Littel-Van Den Hurk;R. P. Braun;P. J. Lewis;B. C. Karvonen

  • The Immunogenicity and Protective Efficacy of Bovine Herpesvirus 1 Glycoprotein D plus Emulsigen Are Increased by Formulation with CpG Oligodeoxynucleotides

    X. P. Ioannou;P. Griebel;R. Hecker;L. A. Babiuk

  • CpG-containing oligodeoxynucleotides, in combination with conventional adjuvants, enhance the magnitude and change the bias of the immune responses to a herpesvirus glycoprotein.

    X.P Ioannou;S.M Gomis;B Karvonen;R Hecker

  • Synthesis and processing of bovine herpesvirus 1 glycoproteins.

    S van Drunen Littel-van den Hurk;L A Babiuk

  • Protection of cattle from BHV-1 infection by immunization with recombinant glycoprotein gIV

    S. van Drunen Littel-van den Hurk;M.D. Parker;B. Massie;J.V. van den Hurk

  • Altering the Cellular Location of an Antigen Expressed by a DNA-Based Vaccine Modulates the Immune Response

    P. J. Lewis;S. van Drunen Littel-van den Hurk;L. A. Babiuk

  • Bovine herpesvirus 1 attachment to permissive cells is mediated by its major glycoproteins gI, gIII, and gIV.

    Xiaoping Liang;L. A. Babiuk;S. Van Drunen Littel Van Den Hurk;D. R. Fitzpatrick

  • Immunopathology of RSV infection : prospects for developing vaccines without this complication

    S. van Drunen Littel-van den Hurk;J. W. Mapletoft;N. Arsic;J. Kovacs-Nolan

  • TLR9-/- and TLR9+/+ mice display similar immune responses to a DNA vaccine.

    Shawn Babiuk;Neeloffer Mookherjee;Reno Pontarollo;Phillip Griebel

  • Epitope specificity of the protective immune response induced by individual bovine herpesvirus-1 glycoproteins.

    S. van Drunen Littel-van den Hurk;G.A. Gifford;L.A. Babiuk

  • A subunit gIV vaccine, produced by transfected mammalian cells in culture, induces mucosal immunity against bovine herpesvirus-1 in cattle.

    S. van Drunen Littel-van den Hurk;J. Van Donkersgoed;J. Kowalski;J.V. van den Hurk

  • Functional and topographical analyses of epitopes on bovine herpesvirus type 1 glycoprotein IV

    G. Hughes;L. A. Babiuk;S. van Drunen Littel-van den Hurk

  • Large animal models for vaccine development and testing.

    Volker Gerdts;Heather L. Wilson;Francois Meurens;Sylvia van Drunen Littel van den Hurk

  • Monocytes are required for optimum in vitro stimulation of bovine peripheral blood mononuclear cells by non-methylated CpG motifs.

    R.A. Pontarollo;R. Rankin;L.A. Babiuk;D.L. Godson

  • Combination adjuvants: the next generation of adjuvants?

    George Mutwiri;Volker Gerdts;Sylvia van Drunen Littel-van den Hurk;Gael Auray

  • Immunization of neonates with DNA encoding a bovine herpesvirus glycoprotein is effective in the presence of maternal antibodies.

    S. Van Drunen Littel-Van Den Hurk;R.P. Braun;P.J. Lewis;B.C. Karvonen

  • Gene Gun-Mediated DNA Immunization Primes Development of Mucosal Immunity against Bovine Herpesvirus 1 in Cattle

    B. I. Loehr;P. Willson;L. A. Babiuk;S. van Drunen Littel-van den Hurk

Frequent Co-Authors

Lorne A. Babiuk
Lorne A. Babiuk University of Alberta
Volker Gerdts
Volker Gerdts University of Saskatchewan
Philip J. Griebel
Philip J. Griebel University of Saskatchewan
Arthur M. Krieg
Arthur M. Krieg University of Massachusetts Chan Medical School
Hugh G.G. Townsend
Hugh G.G. Townsend University of Saskatchewan
Robert E. W. Hancock
Robert E. W. Hancock University of British Columbia
George Mutwiri
George Mutwiri University of Saskatchewan
Frank Blecha
Frank Blecha Kansas State University
Dongwan Yoo
Dongwan Yoo University of Illinois at Urbana-Champaign
Etienne Thiry
Etienne Thiry University of Liège

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