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Randy R. Brutkiewicz

Randy R. Brutkiewicz

D-Index & Metrics

Immunology

D-Index
44
Citations
7469
World Ranking
4783
National Ranking
2145

Research.com Recognitions

  • 2010 - AAI Distinguished Service Award, American Association of Immunologists For dedication and exemplary service to the AAI Minority Affairs Committee, 2005-2009

Overview

Randy R. Brutkiewicz is affiliated with Indiana University in the United States. Their research primarily spans the fields of immunology and microbiology, medicine, and neuroscience. Within these areas, they focus on subfields including immunology, neurology, oncology, molecular biology, and genetics.

The scientist's main topics of work include:

  • Immune Cell Function and Interaction
  • Neuroinflammation and Neurodegeneration Mechanisms
  • CAR-T cell therapy research
  • Immune cells in cancer
  • Alzheimer's disease research and treatments
  • Immune Response and Inflammation
  • Glioma Diagnosis and Treatment

Randy R. Brutkiewicz has contributed frequently to various publication venues, with multiple papers appearing in:

  • Alzheimer s & Dementia
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Neuroimmunology
  • Scientific Reports
  • Regular and Young Investigator Award Abstracts

Their recent papers include:

  • Multispecific targeting of glioblastoma with tumor microenvironment-responsive multifunctional engineered NK cells, 2021, Proceedings of the National Academy of Sciences
  • The Complexity of Microglial Interactions With Innate and Adaptive Immune Cells in Alzheimer's Disease, 2020, Frontiers in Aging Neuroscience
  • Brain astrocytes and microglia express functional MR1 molecules that present microbial antigens to mucosal-associated invariant T (MAIT) cells, 2020, Journal of Neuroimmunology
  • Control of the temporal development of Alzheimer's disease pathology by the MR1/MAIT cell axis, 2023, Journal of Neuroinflammation
  • MR1 overexpression correlates with poor clinical prognosis in glioma patients, 2021, Neuro-Oncology Advances

Frequent co-authors in their publications encompass:

  • Season K. Wyatt-Johnson
  • Raj Priya
  • Jiao Wang
  • Jianyun Liu
  • Yeonhee Yun

Randy R. Brutkiewicz received the AAI Distinguished Service Award from the American Association of Immunologists in 2010 for dedication and exemplary service to the AAI Minority Affairs Committee during 2005-2009.

Best Publications

  • CD1 recognition by mouse NK1+ T lymphocytes

    Albert Bendelac;Albert Bendelac;Olivier Lantz;Mary E. Quimby;Jonathan W. Yewdell

  • Natural Ligand of Mouse CD1d1: Cellular Glycosylphosphatidylinositol

    Sebastian Joyce;Amina S. Woods;Jonathan W. Yewdell;Jack R. Bennink

  • Cell wall glycosphingolipids of Sphingomonas paucimobilis are CD1d-specific ligands for NKT cells.

    Venkataraman Sriram;Wenjun Du;Jacquelyn Gervay-Hague;Randy R. Brutkiewicz

  • Lamp-2a Facilitates MHC Class II Presentation of Cytoplasmic Antigens

    Delu Zhou;Ping Li;Yinling Lin;Jeremy M. Lott

  • Impaired Assembly yet Normal Trafficking of MHC Class I Molecules in Tapasin Mutant Mice

    Andres G Grandea;Tatiana N Golovina;Sara E Hamilton;Venkataraman Sriram

  • CD1d Ligands: The Good, the Bad, and the Ugly

    Randy R. Brutkiewicz

  • Evidence for immune responses to a self-antigen in lung transplantation: Role of type V collagen-specific T cells in the pathogenesis of lung allograft rejection

    M. Azizul Haque;Teruaki Mizobuchi;Kazuhiro Yasufuku;Takehiko Fujisawa

  • TAP-independent, beta 2-microglobulin-dependent surface expression of functional mouse CD1.1.

    Randy Brutkiewicz;Jack R. Bennink;Jonathan W. Yewdell;Albert Bendelac

  • Defective presentation of the CD1d1-restricted natural Va14Ja18 NKT lymphocyte antigen caused by β-d-glucosylceramide synthase deficiency

    Aleksandar K. Stanic;A. Dharshan De Silva;A. Dharshan De Silva;Jang-June Park;Venkataraman Sriram

  • Type I NKT cells protect (and type II NKT cells suppress) the host's innate antitumor immune response to a B-cell lymphoma

    Gourapura J. Renukaradhya;Masood A. Khan;Marcus A. L. Vieira;Wenjun Du

  • Heterosubtypic Immunity to Influenza A Virus in Mice Lacking IgA, All Ig, NKT Cells, or γδ T Cells

    Kimberly A. Benton;Julia A. Misplon;Chia-Yun Lo;Randy R. Brutkiewicz;Randy R. Brutkiewicz

  • Natural killer T (NKT) cells and their role in antitumor immunity.

    Randy R. Brutkiewicz;Venkataraman Sriram

  • Lipid Protein Interactions: The Assembly of CD1d1 with Cellular Phospholipids Occurs in the Endoplasmic Reticulum

    A. Dharshan De Silva;J.-June Park;Naoto Matsuki;Aleksandar K. Stanic

  • Recycling CD1d1 Molecules Present Endogenous Antigens Processed in an Endocytic Compartment to NKT Cells

    Tonya J. Roberts;Venkataraman Sriram;Philip M. Spence;Ming Gui

  • Major histocompatibility complex class I antigens and the control of viral infections by natural killer cells.

    Randy R. Brutkiewicz;Raymond M. Welsh

  • Selective loss of natural killer T cells by apoptosis following infection with lymphocytic choriomeningitis virus.

    Jacqueline A. Hobbs;Sungyoo Cho;Tonya J. Roberts;Venkataraman Sriram

  • CD1d-expressing breast cancer cells modulate NKT cell-mediated antitumor immunity in a murine model of breast cancer metastasis.

    Laura M. Hix;Yihui H. Shi;Randy R. Brutkiewicz;Paul L. Stein

  • Multiple Antigen-Specific Processing Pathways for Activating Naive CD8+ T Cells In Vivo

    Christopher C. Norbury;Michael F. Princiotta;Igor Bacik;Randy R. Brutkiewicz

  • Vaccinia virus blocks Stat1-dependent and Stat1-independent gene expression induced by type I and type II interferons.

    Brandon A. Mann;Julia He Huang;Ping Li;Hua-Chen Chang

  • Inhibition of glycolipid shedding rescues recognition of a CD1+ T cell lymphoma by natural killer T (NKT) cells

    Venkataraman Sriram;Sungyoo Cho;Ping Li;Patrick W. O'Donnell

  • Impaired cell surface expression of human CD1d by the formation of an HIV-1 Nef/CD1d complex

    Sungyoo Cho;Kenneth S. Knox;Lisa M. Kohli;Johnny J. He

  • Cooperation of lymphokine(s) and macrophages in expression of antitumor activity of carboxyethylgermanium sesquioxide (Ge-132).

    F. Suzuki;R. R. Brutkiewicz;Richard B Pollard

Frequent Co-Authors

Mark H. Kaplan
Mark H. Kaplan Indiana University
Janice S. Blum
Janice S. Blum Indiana University
Hal E. Broxmeyer
Hal E. Broxmeyer Indiana University
Luc Van Kaer
Luc Van Kaer Vanderbilt University Medical Center
Richard B. Pollard
Richard B. Pollard University of California, Davis
Sebastian Joyce
Sebastian Joyce Vanderbilt University Medical Center
Alexander L. Dent
Alexander L. Dent Indiana University
Jack R. Bennink
Jack R. Bennink National Institute of Allergy and Infectious Diseases
Giao Hangoc
Giao Hangoc Indiana University
Kyoko Hayakawa
Kyoko Hayakawa Fox Chase Cancer Center

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