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Biology and Biochemistry

D-Index
54
Citations
14013
World Ranking
15443
National Ranking
1215

Overview

Charles A. Mein is affiliated with Queen Mary University of London in the United Kingdom. Their research spans across several fields including Medicine and Biochemistry, Genetics and Molecular Biology. Key subfields of study include Molecular Biology, Endocrinology, Diabetes and Metabolism, Genetics, Pollution, and Surgery.

The scientist has contributed to various topics with a focus on Hormonal Regulation and Hypertension, Adrenal and Paraganglionic Tumors, Pesticide and Herbicide Environmental Studies, Epigenetics and DNA Methylation, Genetically Modified Organisms Research, Pharmaceutical and Antibiotic Environmental Impacts, and Eicosanoids and Hypertension Pharmacology.

Charles A. Mein has published extensively in several venues, with frequent appearances in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of the Endocrine Society
  • Nature Genetics
  • Communications Biology
  • British Journal of Dermatology

Notable recent papers include:

  • [11C]metomidate PET-CT versus adrenal vein sampling for diagnosing surgically curable primary aldosteronism: a prospective, within-patient trial (2023) in Nature Medicine
  • Comparative Toxicogenomics of Glyphosate and Roundup Herbicides by Mammalian Stem Cell-Based Genotoxicity Assays and Molecular Profiling in Sprague-Dawley Rats (2021) in Toxicological Sciences
  • Somatic mutations of GNA11 and GNAQ in CTNNB1-mutant aldosterone-producing adenomas presenting in puberty, pregnancy or menopause (2021) in Nature Genetics
  • Multi-omics phenotyping of the gut-liver axis reveals metabolic perturbations from a low-dose pesticide mixture in rats (2021) in Communications Biology
  • Somatic mutations of CADM1 in aldosterone-producing adenomas and gap junction-dependent regulation of aldosterone production (2023) in Nature Genetics

Collaborations include frequent co-authors such as:

  • Eva Wozniak
  • Claudia Cabrera
  • Morris J. Brown
  • Emily Goodchild
  • Emma Bourne

Best Publications

  • Multiple common variants for celiac disease influencing immune gene expression

    Patrick C. A. Dubois;Gosia Trynka;Lude Franke;Lude Franke;Karen A. Hunt

  • Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease

    Gosia Trynka;Karen A Hunt;Nicholas A Bockett;Jihane Romanos

  • Newly identified genetic risk variants for celiac disease related to the immune response

    Karen A Hunt;Alexandra Zhernakova;Graham Turner;Graham A R Heap

  • High-dose vitamin D(3) during intensive-phase antimicrobial treatment of pulmonary tuberculosis: a double-blind randomised controlled trial.

    Adrian R Martineau;Adrian R Martineau;Peter M Timms;Graham H Bothamley;Yasmeen Hanifa

  • Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma

    Jessica Okosun;Csaba Bödör;Jun Wang;Shamzah Araf

  • Mutations in ABCA12 underlie the severe congenital skin disease harlequin ichthyosis.

    David P. Kelsell;Elizabeth E. Norgett;Harriet Unsworth;Muy Teck Teh

  • Retinoic Acid--Induced Pancreatic Stellate Cell Quiescence Reduces Paracrine Wnt-β-Catenin Signaling to Slow Tumor Progression

    Fieke E.M. Froeling;Christine Feig;Claude Chelala;Richard Dobson

  • A search for type 1 diabetes susceptibility genes in families from the United Kingdom

    Charles A. Mein;Laura Esposito;Michael G. Dunn;Gillian C L Johnson

  • Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatment

    Anna K. Coussens;Robert J. Wilkinson;Robert J. Wilkinson;Yasmeen Hanifa;Vladyslav Nikolayevskyy

  • Identification of Type 1 Diabetes–Associated DNA Methylation Variable Positions That Precede Disease Diagnosis

    Vardhman K. Rakyan;Huriya Beyan;Thomas A. Down;Mohammed I. Hawa

  • Yes-associated protein (YAP) functions as a tumor suppressor in breast.

    M Yuan;V Tomlinson;R Lara;D Holliday

  • Distinctive patterns of microRNA expression associated with karyotype in acute myeloid leukaemia.

    Amanda Dixon-McIver;Phil East;Charles A. Mein;Jean-Baptiste Cazier

  • Genetic Interaction of BBS1 Mutations with Alleles at Other BBS Loci Can Result in Non-Mendelian Bardet-Biedl Syndrome

    Philip L. Beales;Jose L. Badano;Alison J. Ross;Stephen J. Ansley

  • Evaluation of single nucleotide polymorphism typing with invader on PCR amplicons and its automation

    C A Mein;B J Barratt;M G Dunn;T Siegmund

  • Negligible impact of rare autoimmune-locus coding-region variants on missing heritability

    Karen A. Hunt;Vanisha Mistry;Nicholas A. Bockett;Tariq Ahmad

  • A Novel Protective Prion Protein Variant that Colocalizes with Kuru Exposure

    Simon Mead;Jerome Whitfield;Mark Poulter;Paresh Shah

  • Harlequin Ichthyosis: A Review of Clinical and Molecular Findings in 45 Cases

    Shefali Rajpopat;Celia Moss;Jemima Mellerio;Anders Vahlquist

  • A variation in the ghrelin gene increases weight and decreases insulin secretion in tall, obese children.

    Márta Korbonits;Maria Gueorguiev;Eithne O’Grady;Cecile Lecoeur

  • Genome-wide analysis of allelic expression imbalance in human primary cells by high throughput transcriptome resequencing

    Graham A. Heap;Jennie H.M. Yang;Kate Downes;Barry C. Healy

  • Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study

    Anna Rautanen;Tara C Mills;Anthony C Gordon;Paula Hutton

Frequent Co-Authors

Patricia B. Munroe
Patricia B. Munroe Queen Mary University of London
Philippe Froguel
Philippe Froguel Imperial College London
Mark J. Caulfield
Mark J. Caulfield Queen Mary University of London
Stephen Newhouse
Stephen Newhouse King's College London
David P. Kelsell
David P. Kelsell Queen Mary University of London
Martin Farrall
Martin Farrall University of Oxford
Adrian R. Martineau
Adrian R. Martineau Queen Mary University of London
Lude Franke
Lude Franke University Medical Center Groningen
Chris Wallace
Chris Wallace University of Cambridge
John A. Todd
John A. Todd University of Oxford

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