World's Best Scientists 2026 revealed!
Paul A. Clemons

Paul A. Clemons

D-Index & Metrics

Biology and Biochemistry

D-Index
64
Citations
35047
World Ranking
9430
National Ranking
4156

Overview

Paul A. Clemons is affiliated with the Broad Institute in the United States. Their research spans various domains within biochemistry, genetics, and molecular biology, with a significant focus on molecular biology as reflected in their publication record.

The scientist's work concentrates on areas such as computational drug discovery methods, chemical synthesis and analysis, and cell image analysis techniques. Additional topics include protein degradation and inhibitors, click chemistry and applications, advanced biosensing and bioanalysis techniques, and interferon and immune responses.

Clemons has contributed extensively to the scientific literature, including the following notable papers:

  • Plasticity of ether lipids promotes ferroptosis susceptibility and evasion, 2020, Nature
  • Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles, 2020, Nature Chemical Biology
  • An expanded universe of cancer targets, 2021, Cell
  • Predicting compound activity from phenotypic profiles and chemical structures, 2023, Nature Communications
  • Biolink Model: A universal schema for knowledge graphs in clinical, biomedical, and translational science, 2022, Clinical and Translational Science

Their frequent coauthors include Stuart L. Schreiber, Vlado Dančík, Bridget K. Wagner, Bruce K. Hua, and Jeremy W. Mason.

Clemons's publications have appeared predominantly in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Nature, Nature Chemical Biology, and arXiv (Cornell University).

Their subfields of study encompass molecular biology, computational theory and mathematics, pulmonary and respiratory medicine, organic chemistry, and biophysics.

Best Publications

  • Regulation of Ferroptotic Cancer Cell Death by GPX4

    Wan Seok Yang;Rohitha SriRamaratnam;Matthew E. Welsch;Kenichi Shimada

  • The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease

    Justin Lamb;Emily D. Crawford;David Peck;Joshua W. Modell

  • A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.

    Aravind Subramanian;Rajiv Narayan;Steven M. Corsello;Steven M. Corsello;David D. Peck

  • Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

    Vasanthi S. Viswanathan;Matthew J. Ryan;Harshil D. Dhruv;Shubhroz Gill

  • Target identification and mechanism of action in chemical biology and drug discovery

    Monica Schenone;Vlado Dančík;Bridget K Wagner;Paul A Clemons

  • Correlating chemical sensitivity and basal gene expression reveals mechanism of action.

    Matthew G Rees;Brinton Seashore-Ludlow;Brinton Seashore-Ludlow;Jaime H Cheah;Jaime H Cheah;Drew J Adams;Drew J Adams

  • An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules

    Amrita Basu;Nicole E. Bodycombe;Jaime H. Cheah;Edmund V. Price

  • Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset.

    Brinton Seashore-Ludlow;Matthew G. Rees;Jaime H. Cheah;Murat Cokol

  • A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis.

    Yilong Zou;Yilong Zou;Michael J. Palte;Amy A. Deik;Haoxin Li;Haoxin Li

  • Data-analysis strategies for image-based cell profiling

    Juan C. Caicedo;Sam Cooper;Florian Heigwer;Scott Warchal

  • Plasticity of ether lipids promotes ferroptosis susceptibility and evasion

    Yilong Zou;Yilong Zou;Whitney S. Henry;Emily L. Ricq;Emily L. Ricq;Emily T. Graham

  • Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia

    David B. Sykes;Youmna S. Kfoury;François E. Mercier;Mathias J. Wawer

  • ChemBank: a small-molecule screening and cheminformatics resource database

    Kathleen Petri Seiler;Gregory A. George;Mary Pat Happ;Nicole E. Bodycombe

  • Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles

    Paul A. Clemons;Nicole E. Bodycombe;Hyman A. Carrinski;J. Anthony Wilson

  • Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles

    John K. Eaton;Laura Furst;Richard A. Ruberto;Dieter Moosmayer

  • Predicting Cancer-Specific Vulnerability via Data-Driven Detection of Synthetic Lethality

    Livnat Jerby-Arnon;Nadja Pfetzer;Yedael Y. Waldman;Lynn McGarry

  • Route to three-dimensional fragments using diversity-oriented synthesis

    Alvin W. Hung;Alex Ramek;Yikai Wang;Taner Kaya

  • Multiplex cytological profiling assay to measure diverse cellular states.

    Sigrun M. Gustafsdottir;Vebjorn Ljosa;Katherine L. Sokolnicki;J. Anthony Wilson

  • Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

    Nobutaka Kato;Eamon Comer;Tomoyo Sakata-Kato;Arvind Sharma

  • Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia

    Alejandro Gutierrez;Li Pan;Richard W.J. Groen;Frederic Baleydier

Frequent Co-Authors

Stuart L. Schreiber
Stuart L. Schreiber Harvard University
William C. Hahn
William C. Hahn Dana-Farber Cancer Institute
Jesse S. Boehm
Jesse S. Boehm Broad Institute
Todd R. Golub
Todd R. Golub Harvard University
Keith L. Ligon
Keith L. Ligon Harvard University
David E. Root
David E. Root Broad Institute
Francisca Vazquez
Francisca Vazquez Broad Institute
Rameen Beroukhim
Rameen Beroukhim Harvard University
Aviad Tsherniak
Aviad Tsherniak Broad Institute
Pablo Tamayo
Pablo Tamayo University of California, San Diego

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Studying Biology or Biochemistry in the USA opens doors to a diverse range of online degrees and career paths in healthcare and related fields. Many students leverage their foundational science knowledge to pursue professional roles using flexible online programs.

If you are interested in nursing, bridging from an RN qualification to a bachelor's degree is now easier and more cost-effective with options like the cheapest rn to bsn online programs. For those seeking leadership roles, getting a degree in healthcare management can be a fast way to advance your career in hospital administration or policy.

Graduates who wish to specialize further may consider mental health. The fastest pmhnp program is designed for those wanting to become Psychiatric Mental Health Nurse Practitioners. Alternatively, biology and biochemistry backgrounds are ideal for nutrition careers, and accelerated dietitian programs help students quickly qualify as registered dietitians.

These online pathways offer convenience, affordability, and the flexibility to tailor your studies to your interests, making it easier than ever to pursue your ideal role in health and science.

Best Scientists Citing Paul A. Clemons

Trending Scientists

Recently Published Articles