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Biology and Biochemistry

D-Index
64
Citations
15098
World Ranking
9640
National Ranking
167

Overview

Laurent A. Decosterd is affiliated with the University Hospital of Lausanne in Switzerland. The research produced by Laurent spans various topics primarily within the field of Medicine, with a focus on subfields such as Infectious Diseases, Pharmacology, Oncology, Pediatrics, Perinatology and Child Health, and Epidemiology.

Their work concentrates significantly on HIV/AIDS drug development and treatment, antibiotics pharmacokinetics and efficacy, HIV research and treatment, pharmacological effects and toxicity studies, HIV-related health complications and treatments, Pneumocystis jirovecii pneumonia detection and treatment, and HIV/AIDS research and interventions.

Laurent A. Decosterd has contributed to multiple recent publications, including:

  • Validation and clinical application of a multiplex high performance liquid chromatography - tandem mass spectrometry assay for the monitoring of plasma concentrations of 12 antibiotics in patients with severe bacterial infections, 2020, Journal of Chromatography B
  • Long-acting antiretrovirals: a new era for the management and prevention of HIV infection, 2021, Journal of Antimicrobial Chemotherapy
  • The Steps to Therapeutic Drug Monitoring: A Structured Approach Illustrated With Imatinib, 2020, Frontiers in Pharmacology
  • Inhibition of vascular calcification by inositol phosphates derivatized with ethylene glycol oligomers, 2020, Nature Communications
  • A Hyaluronic Acid Hydrogel Loaded with Gentamicin and Vancomycin Successfully Eradicates Chronic Methicillin-Resistant Staphylococcus aureus Orthopedic Infection in a Sheep Model, 2021, Antimicrobial Agents and Chemotherapy

The frequent co-authors collaborating with Laurent include:

  • Thierry Buclin
  • Monia Guidi
  • Catia Marzolini
  • Matthias Cavassini
  • Eva Choong

Laurent A. Decosterd commonly publishes in several academic journals:

  • Journal of Antimicrobial Chemotherapy
  • Journal of Chromatography B
  • Pharmaceutics
  • British Journal of Clinical Pharmacology
  • Clinical Pharmacokinetics

Their scientific contributions are distributed across a considerable number of publications, with a total exceeding 200 works in Medicine. Within this extensive portfolio, Infectious Diseases stands out as the largest subfield with over 50 publications.

Best Publications

  • Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patients.

    Catia Marzolini;Amalio Telenti;Laurent A. Decosterd;Gilbert Greub

  • Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study.

    Jacques Fellay;Catia Marzolini;Emma R. Meaden;David J. Back

  • Influence of CYP2B6 polymorphism on plasma and intracellular concentrations and toxicity of efavirenz and nevirapine in HIV-infected patients.

    Margalida Rotger;Sara Colombo;Hansjakob Furrer;Gabriela Bleiber

  • Towards a new combination therapy for tuberculosis with next generation benzothiazinones

    Vadim Makarov;Benoit Lechartier;Ming Zhang;João Neres

  • Population pharmacokinetics and effects of efavirenz in patients with human immunodeficiency virus infection

    Chantal Csajka;Catia Marzolini;Karin Fattinger;Laurent A. Décosterd

  • Diet acids and alkalis influence calcium retention in bone.

    T. Buclin;M. Cosma;M. Appenzeller;A.-F. Jacquet

  • Drug interactions with the tyrosine kinase inhibitors imatinib, dasatinib, and nilotinib

    Amina Haouala;Nicolas Widmer;Michel A. Duchosal;Michael Montemurro

  • Therapeutic Drug Monitoring of the new targeted anticancer agents imatinib, nilotinib, dasatinib, sunitinib, sorafenib and lapatinib by LC tandem mass spectrometry

    A. Haouala;B. Zanolari;B. Rochat;M. Montemurro

  • Population pharmacokinetics of imatinib and the role of α1-acid glycoprotein

    N. Widmer;L. A. Decosterd;C. Csajka;S. Leyvraz

  • High Cefepime Plasma Concentrations and Neurological Toxicity in Febrile Neutropenic Patients with Mild Impairment of Renal Function

    F. Lamoth;T. Buclin;A. Pascual;S. Vora

  • In vivo analysis of efavirenz metabolism in individuals with impaired CYP2A6 function

    Julia di Iulio;Aurélie Fayet;Mona Arab-Alameddine;Margalida Rotger

  • Multiplex Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry Method for Simultaneous Quantification in Human Plasma of Fluconazole, Itraconazole, Hydroxyitraconazole, Posaconazole, Voriconazole, Voriconazole-N-Oxide, Anidulafungin, and Caspofungin

    Laurent Arthur Decosterd;Bertrand Rochat;Benoît Pesse;Thomas Mercier

  • Pharmacogenetics-based population pharmacokinetic analysis of efavirenz in HIV-1-infected individuals.

    M. Arab-Alameddine;M. Arab-Alameddine;J. Di Iulio;Thierry Buclin;M. Rotger

  • Simultaneous determination of the HIV protease inhibitors indinavir, amprenavir, saquinavir, ritonavir, nelfinavir and the non-nucleoside reverse transcriptase inhibitor efavirenz by high-performance liquid chromatography after solid-phase extraction.

    C Marzolini;A Telenti;T Buclin;J Biollaz

  • Intracellular measurements of anti-HIV drugs indinavir, amprenavir, saquinavir, ritonavir, nelfinavir, lopinavir, atazanavir, efavirenz and nevirapine in peripheral blood mononuclear cells by liquid chromatography coupled to tandem mass spectrometry.

    S. Colombo;A. Beguin;A. Telenti;J. Biollaz

  • Effect of dronedarone on renal function in healthy subjects.

    Yvonne Tschuppert;Thierry Buclin;Laura E. Rothuizen;Laurent A. Decosterd

  • A single LC-tandem mass spectrometry method for the simultaneous determination of 14 antimalarial drugs and their metabolites in human plasma.

    E.M. Hodel;B. Zanolari;T. Mercier;J. Biollaz

  • Transplacental passage of protease inhibitors at delivery.

    Catia Marzolini;Christoph Rudin;Laurent A. Decosterd;Amalio Telenti

  • The role of compartment penetration in PI-monotherapy: the Atazanavir-Ritonavir Monomaintenance (ATARITMO) Trial.

    Pietro Vernazza;Synøve Daneel;Véronique Schiffer;Laurent Decosterd

  • Relationship of imatinib-free plasma levels and target genotype with efficacy and tolerability.

    N Widmer;L A Decosterd;S Leyvraz;M A Duchosal

Frequent Co-Authors

Thierry Buclin
Thierry Buclin University of Lausanne
Amalio Telenti
Amalio Telenti VIR Biotechnology (United States)
Matthias Cavassini
Matthias Cavassini University of Lausanne
Alexandra Calmy
Alexandra Calmy University of Geneva
Huldrych F. Günthard
Huldrych F. Günthard University of Zurich
Manuel Battegay
Manuel Battegay University Hospital of Basel
Blaise Genton
Blaise Genton University of Lausanne
Hansjakob Furrer
Hansjakob Furrer University of Bern
Kurt Hostettmann
Kurt Hostettmann University of Geneva
Pietro Vernazza
Pietro Vernazza University of St. Gallen

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