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Molecular Biology

D-Index
43
Citations
5497
World Ranking
2989
National Ranking
78

Overview

Niels de Wind is affiliated with Leiden University Medical Center in the Netherlands. Their research primarily focuses on genetics and molecular biology with an emphasis on colorectal cancer and related genetic factors.

The scientist has contributed extensively to several fields of study, including:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these broad areas, de Wind's work particularly involves subfields such as:

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cancer Research
  • Genetics
  • Oncology

The main topics addressed in their publications include:

  • Genetic factors in colorectal cancer
  • Cancer Genomics and Diagnostics
  • DNA Repair Mechanisms
  • Genomics and Rare Diseases
  • Colorectal Cancer Screening and Detection
  • RNA Research and Splicing
  • PARP inhibition in cancer therapy

Notable recent publications by Niels de Wind include:

  • "Variation in the risk of colorectal cancer in families with Lynch syndrome: a retrospective cohort study" (2021, The Lancet Oncology)
  • "DNA mismatch repair-dependent DNA damage responses and cancer" (2020, DNA Repair)
  • "Molecular Profile of MSH6-Associated Colorectal Carcinomas Shows Distinct Features From Other Lynch Syndrome-Associated Colorectal Carcinomas" (2023, Gastroenterology)
  • "Two integrated and highly predictive functional analysis-based procedures for the classification of MSH6 variants in Lynch syndrome" (2020, Genetics in Medicine)
  • "Contribution of mRNA Splicing to Mismatch Repair Gene Sequence Variant Interpretation" (2020, Frontiers in Genetics)

The researcher frequently publishes in journals such as:

  • DNA Repair
  • The Lancet Oncology
  • American Journal of Physiology-Endocrinology and Metabolism
  • Gastroenterology
  • Cells

Frequent collaborators in their work include:

  • Emily Rayner
  • Mark Drost
  • Tom van Wezel
  • Maartje Nielsen
  • Yvonne Tiersma

Best Publications

  • Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

    Niels de Wind;Marleen Dekker;Anton Berns;Miroslav Radman

  • The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch.

    Meindert H. Lamers;Anastassis Perrakis;Jacqueline H. Enzlin;Jacqueline H. Enzlin;Herrie H. K. Winterwerp

  • Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice.

    Jacob G. Jansen;Petra Langerak;Anastasia Tsaalbi-Shtylik;Paul van den Berk

  • Involvement of mouse Rev3 in tolerance of endogenous and exogenous DNA damage.

    Petra P. H. Van Sloun;Isabelle Varlet;Edwin Sonneveld;Jan J. W. A. Boei

  • Hypermutation of immunoglobulin genes in memory B cells of DNA repair- deficient mice

    Heinz Jacobs;Yosho Fukita;Gijsbertus T.J. van der Horst;Jan de Boer

  • DNA damage bypass operates in the S and G2 phases of the cell cycle and exhibits differential mutagenicity

    Noam Diamant;Ayal Hendel;Ilan Vered;Thomas Carell

  • Assessment of Functional Effects of Unclassified Genetic Variants

    Fergus J. Couch;Lene Juel Rasmussen;Robert Hofstra;Alvaro N.A. Monteiro

  • Separate domains of Rev1 mediate two modes of DNA damage bypass in mammalian cells.

    Jacob G. Jansen;Anastasia Tsaalbi-Shtylik;Giel Hendriks;Himabindu Gali

  • The BRCT domain of mammalian Rev1 is involved in regulating DNA translesion synthesis

    Jacob G. Jansen;Anastasia Tsaalbi-Shtylik;Petra Langerak;Fabienne Calléja

  • ATP Increases the Affinity between Muts ATPase Domains: Implications for ATP Hydrolysis and Conformational Changes

    Meindert H. Lamers;Dubravka Georgijevic;Joyce H. Lebbink;Herrie H.K. Winterwerp

  • De novo mutations in PLXND1 and REV3L cause Möbius syndrome

    Laura Tomas-Roca;Laura Tomas-Roca;Anastasia Tsaalbi-Shtylik;Jacob G. Jansen;Manvendra K. Singh;Manvendra K. Singh

  • Functional analysis helps to clarify the clinical importance of unclassified variants in DNA mismatch repair genes.

    Jianghua Ou;Renée C. Niessen;Anne Lützen;Rolf H. Sijmons

  • Mammalian polymerase ζ is essential for post-replication repair of UV-induced DNA lesions

    Jacob G. Jansen;Anastasia Tsaalbi-Shtylik;Giel Hendriks;Johan Verspuy

  • Pathological assessment of mismatch repair gene variants in Lynch syndrome: Past, present, and future

    Lene Juel Rasmussen;Christopher D. Heinen;Brigitte Royer-Pokora;Mark Drost

  • A cell-free assay for the functional analysis of variants of the mismatch repair protein MLH1.

    Mark Drost;Jos é B.M. Zonneveld;Linda van Dijk;Hans Morreau

  • Maternal Aldehyde Elimination during Pregnancy Preserves the Fetal Genome

    Nina Oberbeck;Frédéric Langevin;Gareth King;Niels de Wind

  • The translesion polymerase Rev3L in the tolerance of alkylating anticancer drugs

    Wynand Paul Roos;Anastasia Tsaalbi-Shtylik;Roman Tsaryk;Fatma Güvercin

  • Send in the Clamps: Control of DNA Translesion Synthesis in Eukaryotes

    Jacob G. Jansen;Maria I. Fousteri;Niels de Wind

  • Dual role of MutS glutamate 38 in DNA mismatch discrimination and in the authorization of repair

    Joyce H G Lebbink;Dubravka Georgijevic;Ganesh Natrajan;Alexander Fish

  • Tumor characteristics as an analytic tool for classifying genetic variants of uncertain clinical significance

    Robert M.W. Hofstra;Amanda B. Spurdle;Diana M. Eccles;William D. Foulkes

Frequent Co-Authors

Amanda B. Spurdle
Amanda B. Spurdle QIMR Berghofer Medical Research Institute
Sean V. Tavtigian
Sean V. Tavtigian University of Utah
Robert M.W. Hofstra
Robert M.W. Hofstra Erasmus University Rotterdam
Fumio Hanaoka
Fumio Hanaoka National Institute of Genetics
Linda H. Bergersen
Linda H. Bergersen University of Oslo
Vilhelm A. Bohr
Vilhelm A. Bohr University of Copenhagen
Finn Cilius Nielsen
Finn Cilius Nielsen Copenhagen University Hospital
Rolf H. Sijmons
Rolf H. Sijmons University of Groningen
Hein te Riele
Hein te Riele Netherlands Cancer Institute
Titia K. Sixma
Titia K. Sixma Antoni van Leeuwenhoek Hospital

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