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Naoyuki Tsuchiya

Naoyuki Tsuchiya

D-Index & Metrics

Immunology

D-Index
60
Citations
10038
World Ranking
3368
National Ranking
135

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Internal medicine
  • Genetics

The scientist’s investigation covers issues in Immunology, Linkage disequilibrium, Genetics, Allele and Odds ratio. His research integrates issues of Single-nucleotide polymorphism and Genotype in his study of Immunology. Within one scientific family, he focuses on topics pertaining to Haplotype under Single-nucleotide polymorphism, and may sometimes address concerns connected to Epitope, Receptor complex and Human leukocyte antigen.

His Linkage disequilibrium research is multidisciplinary, incorporating elements of Lupus nephritis and FCGR2B. His research investigates the connection between Allele and topics such as Autoimmune disease that intersect with issues in Autoimmunity and Candidate gene. He combines subjects such as Genetic predisposition, Genetic association and Arthritis with his study of Odds ratio.

His most cited work include:

  • Fcgamma receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus: contribution of FCGR2B to genetic susceptibility. (294 citations)
  • FcγRIIB Ile232Thr transmembrane polymorphism associated with human systemic lupus erythematosus decreases affinity to lipid rafts and attenuates inhibitory effects on B cell receptor signaling (196 citations)
  • Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus (193 citations)

What are the main themes of his work throughout his whole career to date?

Naoyuki Tsuchiya mainly focuses on Immunology, Allele, Genetics, Rheumatoid arthritis and Single-nucleotide polymorphism. His Immunology research incorporates themes from Odds ratio and Genotype, Linkage disequilibrium, Haplotype. His Allele research incorporates elements of Genetic predisposition and Exon.

His work deals with themes such as Arthritis, Antibody, Pathogenesis and Interstitial lung disease, which intersect with Rheumatoid arthritis. The study incorporates disciplines such as Lupus erythematosus, Genetic variation and Coding region in addition to Single-nucleotide polymorphism. His Internal medicine research is multidisciplinary, incorporating elements of Gastroenterology and Endocrinology.

He most often published in these fields:

  • Immunology (61.90%)
  • Allele (25.71%)
  • Genetics (25.24%)

What were the highlights of his more recent work (between 2013-2021)?

  • Immunology (61.90%)
  • Allele (25.71%)
  • Odds ratio (18.10%)

In recent papers he was focusing on the following fields of study:

His primary areas of investigation include Immunology, Allele, Odds ratio, Human leukocyte antigen and Genetic association. Naoyuki Tsuchiya interconnects Granulomatosis with polyangiitis and Linkage disequilibrium in the investigation of issues within Immunology. The concepts of his Allele study are interwoven with issues in Case-control study and Hepatitis.

His research integrates issues of Microscopic polyangiitis and Genotype in his study of Odds ratio. His Human leukocyte antigen research integrates issues from Autoantibody, Idiopathic Inflammatory Myopathy, Genetic predisposition and Genetic risk factor. His Genetic association study incorporates themes from Vasculitis and Genome-wide association study.

Between 2013 and 2021, his most popular works were:

  • MUC5B Promoter Variant and Rheumatoid Arthritis with Interstitial Lung Disease. (117 citations)
  • Protective effect of the HLA-DRB1*13:02 allele in Japanese rheumatoid arthritis patients. (60 citations)
  • Transethnic meta-Analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis (36 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Internal medicine
  • Immune system

His scientific interests lie mostly in Immunology, Allele, Odds ratio, Human leukocyte antigen and HLA-DRB1. His Immunology study combines topics from a wide range of disciplines, such as Linkage disequilibrium and Allele frequency. His research in Odds ratio intersects with topics in Rheumatoid arthritis and Genotype.

The Rheumatoid arthritis study combines topics in areas such as Gastroenterology, Rheumatology and Interstitial lung disease. His Human leukocyte antigen study integrates concerns from other disciplines, such as Genetic association and Haplotype. His HLA-DRB1 research is multidisciplinary, incorporating perspectives in Macrophage activation syndrome, Genotyping and Genetic predisposition.

Best Publications

  • MUC5B Promoter Variant and Rheumatoid Arthritis with Interstitial Lung Disease.

    Pierre-Antoine Juge;Joyce S Lee;Esther Ebstein;Hiroshi Furukawa

  • Fc gamma receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus - Contribution of FCGR2B to genetic susceptibility

    Chieko Kyogoku;Hilde M. Dijstelbloem;Naoyuki Tsuchiya;Yoko Hatta

  • Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus

    Nan Shen;Qiong Fu;Qiong Fu;Yun Deng;Yun Deng;Xiaoxia Qian

  • FcγRIIB Ile232Thr transmembrane polymorphism associated with human systemic lupus erythematosus decreases affinity to lipid rafts and attenuates inhibitory effects on B cell receptor signaling

    Hajime Kono;Chieko Kyogoku;Takeshi Suzuki;Naoyuki Tsuchiya

  • BAFF/BLyS can potentiate B-cell selection with the B-cell coreceptor complex

    Hidenori Hase;Yumiko Kanno;Masaru Kojima;Kaoru Hasegawa

  • Effects of galactose depletion from oligosaccharide chains on immunological activities of human IgG.

    Tsuchiya N;Endo T;Matsuta K;Yoshinoya S

  • Association of Fcgamma receptor IIb and IIIb polymorphisms with susceptibility to systemic lupus erythematosus in Thais.

    U. Siriboonrit;N. Tsuchiya;M. Sirikong;C. Kyogoku

  • Association of Fcgamma receptor IIb polymorphism with susceptibility to systemic lupus erythematosus in Chinese: a common susceptibility gene in the Asian populations.

    Z.T. Chu;N. Tsuchiya;C. Kyogoku;J. Ohashi;J. Ohashi

  • Association of tumor necrosis factor receptor 2 (TNFR2) polymorphism with susceptibility to systemic lupus erythematosus.

    T. Komata;N. Tsuchiya;M. Matsushita;K. Hagiwara

  • Association of HLA-B39 with HLA-B27-negative ankylosing spondylitis and pauciarticular juvenile rheumatoid arthritis in Japanese patients. Evidence for a role of the peptide-anchoring B pocket.

    Akihiro Yamaguchi;Naoyuki Tsuchiya;Naoyuki Tsuchiya;Hiroshi Mitsui;Michiko Shiota

  • Association of Fcγ receptor IIIB, but not of Fcγ receptor IIA and IIIA polymorphisms with systemic lupus erythematosus in Japanese

    Y Hatta;N Tsuchiya;J Ohashi;M Matsushita

  • Analysis on the association of human BLYS (BAFF, TNFSF13B) polymorphisms with systemic lupus erythematosus and rheumatoid arthritis.

    A Kawasaki;N Tsuchiya;T Fukazawa;H Hashimoto

  • Association of a functional polymorphism in the IRF5 region with systemic sclerosis in a Japanese population.

    Ikue Ito;Yasushi Kawaguchi;Aya Kawasaki;Minoru Hasegawa

  • Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of the STAT1-STAT4 region.

    Aya Kawasaki;Ikue Ito;Koki Hikami;Jun Ohashi

  • Crucial Role of Inhibitor of DNA Binding/Differentiation in the Vascular Endothelial Growth Factor-Induced Activation and Angiogenic Processes of Human Endothelial Cells.

    Daisuke Sakurai;Naoyuki Tsuchiya;Akihiro Yamaguchi;Yurai Okaji

  • Association of the FAM167A–BLK region with systemic sclerosis

    Ikue Ito;Yasushi Kawaguchi;Aya Kawasaki;Minoru Hasegawa

  • A compass that points to lupus: genetic studies on type I interferon pathway.

    Chieko Kyogoku;Chieko Kyogoku;Naoyuki Tsuchiya

  • Association of IRF5 polymorphisms with systemic lupus erythematosus in a Japanese population: support for a crucial role of intron 1 polymorphisms.

    Aya Kawasaki;Chieko Kyogoku;Jun Ohashi;Risa Miyashita

  • Genetic background of Japanese patients with antineutrophil cytoplasmic antibody-associated vasculitis: association of HLA-DRB1*0901 with microscopic polyangiitis.

    Naoyuki Tsuchiya;Shigeto Kobayashi;Aya Kawasaki;Chieko Kyogoku

  • MIC-A polymorphism in Japanese and a MIC-A-MIC-B null haplotype.

    Miki Komatsu-Wakui;K. Tokunaga;Yoshihide Ishikawa;Kouichi Kashiwase

Frequent Co-Authors

Katsushi Tokunaga
Katsushi Tokunaga University of Tokyo
Jun Ohashi
Jun Ohashi University of Tokyo
Takayuki Sumida
Takayuki Sumida University of Tsukuba
Hiroshi Hashimoto
Hiroshi Hashimoto Juntendo University
Yoshinari Takasaki
Yoshinari Takasaki Juntendo University
Kiyoshi Migita
Kiyoshi Migita Fukushima Medical University
Kazuhiko Takehara
Kazuhiko Takehara Kanazawa University
Manabu Fujimoto
Manabu Fujimoto Osaka University
Minoru Hasegawa
Minoru Hasegawa University of Fukui
Shinichi Sato
Shinichi Sato University of Tokyo

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