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Molecular Biology

D-Index
82
Citations
40195
World Ranking
915
National Ranking
485

Overview

Michael T. McManus is affiliated with the University of California, San Francisco in the United States. Their research primarily resides within the field of Biochemistry, Genetics and Molecular Biology, with a focus on Molecular Biology, Cancer Research, Plant Science, Immunology, and Pulmonary and Respiratory Medicine. The scientist's work covers multiple specialized topics including MicroRNA in disease regulation, RNA modifications and cancer, Genomics and Chromatin Dynamics, Extracellular vesicles in disease, RNA Research and Splicing, RNA and protein synthesis mechanisms, and Genomics and Phylogenetic Studies.

Recent papers authored by Michael T. McManus highlight their active engagement in various research areas. These publications include:

  • CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling, 2020, Cell
  • Macrophage Exosomes Resolve Atherosclerosis by Regulating Hematopoiesis and Inflammation via MicroRNA Cargo, 2020, Cell Reports
  • An expanded universe of cancer targets, 2021, Cell
  • Examining the evidence for extracellular RNA function in mammals, 2021, Nature Reviews Genetics
  • miR-200 deficiency promotes lung cancer metastasis by activating Notch signaling in cancer-associated fibroblasts, 2021, Genes & Development

Frequent co-authors in Michael T. McManus's publications include:

  • Sheila Q. Xie
  • Bryony Leeke
  • Ryan T. Wagner
  • Paul Chammas
  • Dirk Dormann

The scientist's research is often disseminated through prominent publication venues, reflecting recurring contributions to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell Reports
  • F1000Research
  • Cell
  • Genes & Development

The research topics and publication patterns indicate a concentration on RNA biology, particularly microRNA functions and the role of extracellular vesicles in disease contexts. Their work encompasses cellular signaling pathways, cancer mechanisms, and regulatory processes connected to RNA modifications and chromatin dynamics.

Best Publications

  • Integrative analysis of 111 reference human epigenomes

    Anshul Kundaje;Wouter Meuleman;Wouter Meuleman;Jason Ernst

  • Gene silencing in mammals by small interfering RNAs

    Michael T. McManus;Phillip A. Sharp

  • A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

    Douglas A Rubinson;Christopher P Dillon;Adam V Kwiatkowski;Claudia Sievers;Claudia Sievers

  • Dysregulation of Cardiogenesis, Cardiac Conduction, and Cell Cycle in Mice Lacking miRNA-1-2

    Yong Zhao;Joshua F. Ransom;Ankang Li;Ankang Li;Vasanth Vedantham

  • Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

    Matthew J. Hangauer;Vasanthi S. Viswanathan;Matthew J. Ryan;Dhruv Bole

  • TAZ, a transcriptional modulator of mesenchymal stem cell differentiation.

    Jeong Ho Hong;Eun Sook Hwang;Michael T. McManus;Adam Amsterdam

  • Pervasive transcription of the human genome produces thousands of previously unidentified long intergenic noncoding RNAs.

    Matthew J. Hangauer;Ian W. Vaughn;Michael T. McManus

  • The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb

    Brian D. Harfe;Michael T. McManus;Jennifer H. Mansfield;Eran Hornstein

  • RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription

    Qing Ge;Michael T. McManus;Tam Nguyen;Ching-Hung Shen

  • Cre-lox-regulated conditional RNA interference from transgenes

    Andrea Ventura;Alexander Meissner;Christopher P. Dillon;Michael McManus

  • IRE1α Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2

    John-Paul Upton;Likun Wang;Dan Han;Eric S. Wang

  • Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity

    Xuyu Zhou;Lukas T. Jeker;Brian T. Fife;Shirley Zhu

  • Dicer1 and miR-219 Are Required for Normal Oligodendrocyte Differentiation and Myelination

    Jason C. Dugas;Trinna L. Cuellar;Anja Scholze;Brandon Ason

  • Chd1 regulates open chromatin and pluripotency of embryonic stem cells

    Alexandre Gaspar-Maia;Adi Alajem;Fanny Polesso;Rupa Sridharan

  • Gene silencing using micro-RNA designed hairpins.

    Michael T. McMANUS;Christian P. Petersen;Brian B. Haines;Jianzhu Chen

  • MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression

    Jennifer H Mansfield;Brian D Harfe;Brian D Harfe;Robert Nissen;John Obenauer

  • The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development

    Eran Hornstein;Jennifer H. Mansfield;Soraya Yekta;Jimmy Kuang-Hsien Hu

  • Conditional Loss of Dicer Disrupts Cellular and Tissue Morphogenesis in the Cortex and Hippocampus

    Tigwa H. Davis;Trinna L. Cuellar;Selina M. Koch;Allison J. Barker

  • MicroRNAs and cancer.

    Michael T McManus

  • Abstract 1006: Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

    Matthew J. Hangauer;Vasanthi S. Viswanathan;Matthew J. Ryan;Dhruv Bole

Frequent Co-Authors

Brian D. Harfe
Brian D. Harfe University of Florida
Andrei Goga
Andrei Goga University of California, San Francisco
Michael C. Bassik
Michael C. Bassik Stanford University
Stuart L. Schreiber
Stuart L. Schreiber Harvard University
William A. Laing
William A. Laing Plant & Food Research
K. Mark Ansel
K. Mark Ansel University of California, San Francisco
Axel Visel
Axel Visel Lawrence Berkeley National Laboratory
Len A. Pennacchio
Len A. Pennacchio Lawrence Berkeley National Laboratory

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