Michael T. McManus focuses on Cell biology, Genetics, microRNA, Gene silencing and Molecular biology. His Cell biology research is multidisciplinary, incorporating elements of Cellular differentiation, Transcription factor, Regulation of gene expression, Centrosome cycle and Centriole elongation. Michael T. McManus frequently studies issues relating to Computational biology and Genetics.
Michael T. McManus has included themes like Erg, Retinal, Ribonuclease III, Zebrafish and Dicer in his microRNA study. His studies deal with areas such as Endocrinology, Gene expression, Internal medicine, Messenger RNA and HOXB8 as well as Gene silencing. His research on Molecular biology also deals with topics like
Michael T. McManus spends much of his time researching Cell biology, microRNA, Genetics, Molecular biology and Biochemistry. Michael T. McManus focuses mostly in the field of Cell biology, narrowing it down to matters related to Embryonic stem cell and, in some cases, Chromatin. His microRNA research includes elements of Cancer research, Gene expression, Ribonuclease III, Regulation of gene expression and Gene silencing.
His biological study spans a wide range of topics, including Knockout mouse and Argonaute. His Genetics study frequently links to other fields, such as Computational biology. As a part of the same scientific study, Michael T. McManus usually deals with the Molecular biology, concentrating on Small hairpin RNA and frequently concerns with Cancer.
His scientific interests lie mostly in Cell biology, Gene, Computational biology, Cancer research and microRNA. The Cell biology study combines topics in areas such as RNA, RNA interference, Transcription factor, Internal medicine and Transcription. His Gene study introduces a deeper knowledge of Genetics.
He applies his multidisciplinary studies on Genetics and Decoding methods in his research. His studies in Computational biology integrate themes in fields like Function, CRISPR, Genetic screen and Genomics. His study explores the link between microRNA and topics such as Haematopoiesis that cross with problems in Dicer, Argonaute, Biogenesis and Phenocopy.
The scientist’s investigation covers issues in Cell biology, Gene, Computational biology, Immune system and Genetics. He works in the field of Cell biology, focusing on Progenitor cell in particular. His Gene study integrates concerns from other disciplines, such as Cell and Innate immune system.
His work deals with themes such as Druggability, Genome and Human proteins, which intersect with Computational biology. Genetics is often connected to Allergic inflammation in his work. His Transcription factor research is multidisciplinary, incorporating perspectives in Gene expression, NF-κB, IκBα and CRISPR.
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Integrative analysis of 111 reference human epigenomes
Anshul Kundaje;Wouter Meuleman;Wouter Meuleman;Jason Ernst.
Gene silencing in mammals by small interfering RNAs
Michael T. McManus;Phillip A. Sharp.
Nature Reviews Genetics (2002)
A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference
Douglas A Rubinson;Christopher P Dillon;Adam V Kwiatkowski;Claudia Sievers;Claudia Sievers.
Nature Genetics (2003)
Dysregulation of Cardiogenesis, Cardiac Conduction, and Cell Cycle in Mice Lacking miRNA-1-2
Yong Zhao;Joshua F. Ransom;Ankang Li;Ankang Li;Vasanth Vedantham.
TAZ, a transcriptional modulator of mesenchymal stem cell differentiation.
Jeong Ho Hong;Eun Sook Hwang;Michael T. McManus;Adam Amsterdam.
The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb
Brian D. Harfe;Michael T. McManus;Jennifer H. Mansfield;Eran Hornstein.
Proceedings of the National Academy of Sciences of the United States of America (2005)
Cre-lox-regulated conditional RNA interference from transgenes
Andrea Ventura;Alexander Meissner;Christopher P. Dillon;Michael McManus.
Proceedings of the National Academy of Sciences of the United States of America (2004)
RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription
Qing Ge;Michael T. McManus;Tam Nguyen;Ching-Hung Shen.
Proceedings of the National Academy of Sciences of the United States of America (2003)
Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition
Matthew J. Hangauer;Vasanthi S. Viswanathan;Matthew J. Ryan;Dhruv Bole.
Pervasive transcription of the human genome produces thousands of previously unidentified long intergenic noncoding RNAs.
Matthew J. Hangauer;Ian W. Vaughn;Michael T. McManus.
PLOS Genetics (2013)
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