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Makoto Nakanishi

Makoto Nakanishi

D-Index & Metrics

Molecular Biology

D-Index
66
Citations
15220
World Ranking
1619
National Ranking
136

Overview

Makoto Nakanishi is affiliated with the University of Tokyo in Japan and has contributed extensively to the fields of Biochemistry, Genetics, and Molecular Biology, with over 105 publications. Their work also spans Medicine with 51 related publications. The primary subfields of study include Molecular Biology, Genetics, Immunology, Physiology, and Oncology.

The main topics covered in Nakanishi's research are:

  • Epigenetics and DNA Methylation
  • Telomeres, Telomerase, and Senescence
  • RNA modifications and cancer
  • Cancer-related gene regulation
  • Ubiquitin and proteasome pathways
  • Immune cells in cancer
  • DNA Repair Mechanisms

Nakanishi has frequently published in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory), 10 publications
  • Nature Communications, 6 publications
  • The Journal of Biochemistry, 5 publications
  • Nucleic Acids Research, 3 publications
  • Nature Aging, 3 publications

Among recent notable papers authored by Nakanishi are:

  • "Navigating the DNA methylation landscape of cancer" (2021) in Trends in Genetics
  • "Blocking PD-L1-PD-1 improves senescence surveillance and ageing phenotypes" (2022) in Nature
  • "Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders" (2021) in Science
  • "Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In Vivo" (2020) in Cell Metabolism
  • "Sentinel p16 INK4a+ cells in the basement membrane form a reparative niche in the lung" (2022) in Science

Frequent collaborators in Nakanishi's work include:

  • Atsuya Nishiyama (27 coauthored works)
  • Yoshikazu Johmura (24 coauthored works)
  • Yoshie Chiba (14 coauthored works)
  • Kyohei Arita (14 coauthored works)
  • Kiyoshi Yamaguchi (10 coauthored works)

The research conducted by Nakanishi covers a broad spectrum within molecular and cellular biology, emphasizing mechanisms related to aging, cancer biology, and gene regulation. Their involvement in studies on DNA methylation and senescence highlights intersections of epigenetics with disease phenotypes and cellular aging processes.

Best Publications

  • Aberrant cell cycle checkpoint function and early embryonic death in Chk1 −/− mice

    Hiroyuki Takai;Kaoru Tominaga;Noboru Motoyama;Yohji A. Minamishima

  • DNA damage checkpoints in mammals.

    Hiroyuki Niida;Makoto Nakanishi

  • CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein.

    Nikolai A. Timchenko;Margie Wilde;Makoto Nakanishi;James R. Smith

  • Navigating the DNA methylation landscape of cancer.

    Atsuya Nishiyama;Makoto Nakanishi

  • Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription.

    Hiroyuki Takai;Kazuhito Naka;Yuki Okada;Miho Watanabe

  • NAK is an IκB kinase-activating kinase

    Yuichiro Tojima;Atsushi Fujimoto;Mireille Delhase;Yi Chen

  • Eukaryotic DNA polymerases: proposal for a revised nomenclature.

    Peter M J Burgers;Eugene V. Koonin;Elspeth Bruford;Luis Blanco

  • Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders.

    Yoshikazu Johmura;Takehiro Yamanaka;Satotaka Omori;Teh Wei Wang

  • Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication

    Atsuya Nishiyama;Luna Yamaguchi;Jafar Sharif;Yoshikazu Johmura

  • A degradation signal located in the C‐terminus of p21WAF1/CIP1 is a binding site for the C8 α‐subunit of the 20S proteasome

    Robert Touitou;Jo Richardson;Suchira Bose;Makoto Nakanishi

  • Chk2 Activation Dependence on Nbs1 after DNA Damage

    Giacomo Buscemi;Camilla Savio;Laura Zannini;Francesca Miccichè

  • Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression.

    Midori Shimada;Hiroyuki Niida;Doaa H. Zineldeen;Hideaki Tagami

  • Hepatitis B virus genotype distribution among chronic hepatitis B virus carriers in Shanghai, China.

    Xin Ding;Masashi Mizokami;Guangbi Yao;Bei Xu

  • Identification of the active region of the DNA synthesis inhibitory gene P21Sdi1/CIP1/WAF1

    Makoto Nakanishi;Ryan S. Robetorye;Guy R. Adami;Olivia M. Pereira-Smith

  • Identification of NAP1, a Regulatory Subunit of IκB Kinase-Related Kinases That Potentiates NF-κB Signaling

    Fumitaka Fujita;Yuko Taniguchi;Takashi Kato;Yasuko Narita

  • Specific role of Chk1 phosphorylations in cell survival and checkpoint activation.

    Hiroyuki Niida;Yuko Katsuno;Birendranath Banerjee;M. Prakash Hande

  • A20 is a negative regulator of IFN regulatory factor 3 signaling.

    Tatsuya Saitoh;Masahiro Yamamoto;Makoto Miyagishi;Makoto Miyagishi;Kazunari Taira;Kazunari Taira

  • CCAAT/Enhancer-binding Protein-α Cooperates with p21 to Inhibit Cyclin-dependent Kinase-2 Activity and Induces Growth Arrest Independent of DNA Binding

    Thurl E. Harris;Jeffrey H. Albrecht;Makoto Nakanishi;Gretchen J. Darlington

  • Necessary and Sufficient Role for a Mitosis Skip in Senescence Induction

    Yoshikazu Johmura;Midori Shimada;Toshinori Misaki;Aya Naiki-Ito

  • Cell-cycle-dependent and ATM-independent expression of human Chk1 kinase.

    Yokos Kaneko;Nobumoto Watanabe;Hirobumi Morisaki;Hidetoshi Akita

Frequent Co-Authors

Yasuo Kagawa
Yasuo Kagawa Kagawa Nutrition University
Masashi Mizokami
Masashi Mizokami National Center For Global Health and Medicine
Haruhiko Koseki
Haruhiko Koseki RIKEN Center for Integrative Medical Sciences
Ryoji Noyori
Ryoji Noyori Nagoya University
Olivia M. Pereira-Smith
Olivia M. Pereira-Smith The University of Texas Health Science Center at San Antonio
Keiichi I. Nakayama
Keiichi I. Nakayama Institute of Science Tokyo
Yoji Arata
Yoji Arata University of Tokyo
Shigeaki Kato
Shigeaki Kato University of Tokyo
Domenico Delia
Domenico Delia University of Milan
Yasuyoshi Watanabe
Yasuyoshi Watanabe Osaka Metropolitan University

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