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Biology and Biochemistry

D-Index
51
Citations
9514
World Ranking
17156
National Ranking
7067

Overview

Nikolai A. Timchenko is affiliated with Cincinnati Children's Hospital Medical Center in the United States. Their research interests lie primarily within the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, focusing particularly on Molecular Biology, Cancer Research, Oncology, Pathology and Forensic Medicine, and Pediatrics, Perinatology and Child Health.

The major topics addressed in their work include:

  • RNA modifications and cancer
  • Epigenetics and DNA Methylation
  • Ubiquitin and proteasome pathways
  • Mitochondrial Function and Pathology
  • Metal-Catalyzed Oxygenation Mechanisms
  • Cancer, Hypoxia, and Metabolism
  • Histone Deacetylase Inhibitors Research

Timchenko has published extensively in several scientific journals. Frequent publication venues include:

  • Cancers
  • Cellular and Molecular Gastroenterology and Hepatology
  • Hepatology Communications
  • International Journal of Molecular Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)

Significant recent papers from Timchenko's research include:

  • METTL16 promotes liver cancer stem cell self-renewal via controlling ribosome biogenesis and mRNA translation, 2024, Journal of Hematology & Oncology
  • HDAC1-Dependent Repression of Markers of Hepatocytes and P21 Is Involved in Development of Pediatric Liver Cancer, 2021, Cellular and Molecular Gastroenterology and Hepatology
  • Ribonucleotide reductase subunit switching in hepatoblastoma drug response and relapse, 2023, Communications Biology
  • Hepatoblastomas exhibit marked NNMT downregulation driven by promoter DNA hypermethylation, 2020, Tumor Biology
  • Olaparib Inhibits Tumor Growth of Hepatoblastoma in Patient-Derived Xenograft Models, 2021, Hepatology

Frequent co-authors contributing to their research include Ruhi Gulati, James I. Geller, Lubov Timchenko, Gregory M. Tiao, and Michael E. Johnston.

Best Publications

  • CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein.

    Nikolai A. Timchenko;Margie Wilde;Makoto Nakanishi;James R. Smith

  • C/EBPα Arrests Cell Proliferation through Direct Inhibition of Cdk2 and Cdk4

    Hongmei Wang;Polina Iakova;Margie Wilde;Alana Welm

  • Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression.

    Duygu Dee Harrison-Findik;Denise Schafer;Elizabeth Klein;Nikolai A. Timchenko

  • RNA CUG Repeats Sequester CUGBP1 and Alter Protein Levels and Activity of CUGBP1

    Nikolai A. Timchenko;Zong Jin Cai;Alana L. Welm;Sita Reddy

  • Aging Reduces Proliferative Capacities of Liver by Switching Pathways of C/EBPα Growth Arrest

    Polina Iakova;Samir S Awad;Nikolai A Timchenko

  • CCAAT/enhancer binding protein alpha regulates p21 protein and hepatocyte proliferation in newborn mice.

    N A Timchenko;T E Harris;M Wilde;T A Bilyeu

  • Overexpression of CUG Triplet Repeat-binding Protein, CUGBP1, in Mice Inhibits Myogenesis

    Nikolai A. Timchenko;Roma Patel;Polina Iakova;Zong-Jin Cai

  • Molecular basis for impaired muscle differentiation in myotonic dystrophy.

    Nikolai A. Timchenko;Polina Iakova;Zong-Jin Cai;James R. Smith

  • Aging and liver regeneration.

    Nikolai A. Timchenko

  • CUG repeat binding protein (CUGBP1) interacts with the 5′ region of C/EBPβ mRNA and regulates translation of C/EBPβ isoforms

    Nikolai A. Timchenko;Alana L. Welm;Xiaohui Lu;Lubov T. Timchenko

  • Autoregulation of the human C/EBP alpha gene by stimulation of upstream stimulatory factor binding.

    N Timchenko;D R Wilson;L R Taylor;S Abdelsayed

  • Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBPα growth inhibitory activity

    Guo-Li Wang;Polina Iakova;Margie Wilde;Samir Awad

  • Competition of CUGBP1 and calreticulin for the regulation of p21 translation determines cell fate

    Polina Iakova;Guo-Li Wang;Lubov Timchenko;Marek Michalak

  • Iron-mediated regulation of liver hepcidin expression in rats and mice is abolished by alcohol

    Duygu Dee Harrison-Findik;Elizabeth Klein;Callie Crist;John Evans

  • Cardiac Elav-type RNA-binding Protein (ETR-3) Binds to RNA CUG Repeats Expanded in Myotonic Dystrophy

    Xiaohui Lu;Nikolai A. Timchenko;Lubov T. Timchenko

  • C/EBPα Regulates Generation of C/EBPβ Isoforms through Activation of Specific Proteolytic Cleavage

    Alana L. Welm;Nikolai A. Timchenko;Gretchen J. Darlington

  • C/EBPα Regulates Formation of S-Phase-Specific E2F-p107 Complexes in Livers of Newborn Mice

    Nikolai A. Timchenko;Margie Wilde;Gretchen J. Darlington

  • GSK3β mediates muscle pathology in myotonic dystrophy

    Karlie Jones;Christina Wei;Polina Iakova;Enrico Bugiardini

  • CBFB-SMMHC is correlated with increased calreticulin expression and suppresses the granulocytic differentiation factor CEBPA in AML with inv(16)

    Daniel Helbling;Beatrice U. Mueller;Nikolai A. Timchenko;Julian Schardt

  • CCAAT/Enhancer Binding Protein a Regulates p21 Protein and Hepatocyte Proliferation in Newborn Mice

    Nikolai A. Timchenko;Thurl E. Harris;Margaret Wilde;Timothy A. Bilyeu

Frequent Co-Authors

Gretchen J. Darlington
Gretchen J. Darlington Baylor College of Medicine
Alana L. Welm
Alana L. Welm University of Utah
Milton J. Finegold
Milton J. Finegold Baylor College of Medicine
Benedikt Schoser
Benedikt Schoser Ludwig-Maximilians-Universität München
Roy G. Smith
Roy G. Smith Scripps Research Institute
Martin F. Fey
Martin F. Fey University of Bern
Olivia M. Pereira-Smith
Olivia M. Pereira-Smith The University of Texas Health Science Center at San Antonio
James R. Woodgett
James R. Woodgett Lunenfeld-Tanenbaum Research Institute
David P. Witte
David P. Witte Cincinnati Children's Hospital Medical Center
David L. Nelson
David L. Nelson Baylor College of Medicine

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