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Biology and Biochemistry

D-Index
60
Citations
12346
World Ranking
11999
National Ranking
5149

Overview

Alan D. Friedman is affiliated with Johns Hopkins University in the United States. Their research primarily focuses on medicine and immunology and microbiology, with significant contributions to related subfields such as immunology, hematology, molecular biology, neurology, and pathology and forensic medicine.

The scientist's work involves several key topics, including:

  • Immune cells in cancer
  • Immunotherapy and Immune Responses
  • Immune Cell Function and Interaction
  • Acute Myeloid Leukemia Research
  • Neuroblastoma Research and Treatments
  • Erythrocyte Function and Pathophysiology
  • Melanoma and MAPK Pathways

Alan D. Friedman has published extensively, with work appearing frequently in the following venues:

  • Regular and Young Investigator Award Abstracts
  • Journal for ImmunoTherapy of Cancer
  • Molecular Case Studies
  • Molecular Oncology
  • PLoS ONE

Recent notable publications include:

  • NF-κB p50-deficient immature myeloid cell (p50-IMC) adoptive transfer slows the growth of murine prostate and pancreatic ductal carcinoma (2020, Journal for ImmunoTherapy of Cancer)
  • BRAF V600E-mutated metastatic pediatric Wilms tumor with complete response to targeted RAF/MEK inhibition (2020, Molecular Case Studies)
  • Adoptive transfer of immature myeloid cells lacking NF-κB p50 (p50-IMC) impedes the growth of MHC-matched high-risk neuroblastoma (2021, Molecular Oncology)
  • C/EBPα induces Ebf1 gene expression in common lymphoid progenitors (2020, PLoS ONE)
  • 344 Human macrophages lacking NF-κB p50 display increased proinflammatory cytokine expression (2023, Regular and Young Investigator Award Abstracts)

Frequent coauthors with whom Friedman has collaborated include:

  • Theresa J. Barberi
  • Rahul Suresh
  • David J. Barakat
  • Elizabeth M. Jaffee
  • Kenneth J. Pienta

Best Publications

  • Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes.

    R. J. Christy;V. W. Yang;J. M. Ntambi;D. E. Geiman

  • Transcriptional control of granulocyte and monocyte development.

    A D Friedman

  • A novel temporal expression pattern of three C/EBP family members in differentiating myelomonocytic cells.

    Linda M. Scott;Curt I. Civin;Pernille Rorth;Alan D. Friedman

  • PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2 beta/CBF beta proto-oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells.

    Issarang Nuchprayoon;Shari Meyers;Linda M. Scott;Joseph Suzow

  • Transcriptional regulation of granulocyte and monocyte development

    Alan D Friedman

  • C/EBP, c-Myb, and PU.1 cooperate to regulate the neutrophil elastase promoter.

    Michael Oelgeschläger;Issarang Nuchprayoon;Bernhard Lüscher;Alan D. Friedman

  • Multiple Functional Domains of AML1: PU.1 and C/EBPα Synergize with Different Regions of AML1

    Martha S. Petrovick;Scott W. Hiebert;Alan D. Friedman;Christopher J. Hetherington

  • The role of the CCAAT/enhancer-binding protein in the transcriptional regulation of the gene for phosphoenolpyruvate carboxykinase (GTP).

    Edwards A. Park;William J. Roesler;Jinsong Liu;Dwight J. Klemm

  • C/EBPalpha bypasses granulocyte colony-stimulating factor signals to rapidly induce PU.1 gene expression, stimulate granulocytic differentiation, and limit proliferation in 32D cl3 myeloblasts.

    Xinping Wang;Edward Scott;Edward Scott;Edward Scott;Charles L. Sawyers;Charles L. Sawyers;Charles L. Sawyers;Alan D. Friedman;Alan D. Friedman;Alan D. Friedman

  • Internal tandem duplication mutation of FLT3 blocks myeloid differentiation through suppression of C/EBPα expression

    Rui Zheng;Alan D. Friedman;Mark Levis;Li Li

  • The inv(16) Fusion Protein Associates with Corepressors via a Smooth Muscle Myosin Heavy-Chain Domain

    Kristie L. Durst;Bart Lutterbach;Bart Lutterbach;Bart Lutterbach;Tanawan Kummalue;Alan D. Friedman

  • GADD153/CHOP, a DNA Damage-inducible Protein, Reduced CAAT/Enhancer Binding Protein Activities and Increased Apoptosis in 32D cl3 Myeloid Cells

    Alan D. Friedman

  • TLE, the human homolog of Groucho, interacts with AML1 and acts as a repressor of AML1-induced transactivation

    Yoichi Imai;Mineo Kurokawa;Kozo Tanaka;Alan D. Friedman

  • HES1 Inhibits Cycling of Hematopoietic Progenitor Cells via DNA Binding

    Xiaobing Yu;Jonathan K. Alder;Jong Ho Chun;Alan D. Friedman

  • TEL-AML1, expressed from t(12;21) in human acute lymphocytic leukemia, induces acute leukemia in mice.

    Florence Bernardin;Yandan Yang;Rebecca Cleaves;Marianna Zahurak

  • The murine myeloperoxidase promoter contains several functional elements, one of which binds a cell type-restricted transcription factor, myeloid nuclear factor 1 (MyNF1).

    J Suzow;A D Friedman

  • Core binding factor cannot synergistically activate the myeloperoxidase proximal enhancer in immature myeloid cells without c-Myb.

    Martin Britos-Bray;Alan D. Friedman

  • C/EBPα binds and activates the PU.1 distal enhancer to induce monocyte lineage commitment

    Christine Yeamans;Dehua Wang;Ido Paz-Priel;Bruce E. Torbett

  • AML1/RUNX1 increases during G1 to S cell cycle progression independent of cytokine-dependent phosphorylation and induces cyclin D3 gene expression

    Florence Bernardin-Fried;Tanawan Kummalue;Suzanne Leijen;Michael I. Collector

  • Targeted inhibition of FLT3 overcomes the block to myeloid differentiation in 32Dcl3 cells caused by expression of FLT3/ITD mutations.

    Rui Zheng;Alan D. Friedman;Donald Small

Frequent Co-Authors

Curt I. Civin
Curt I. Civin University of Maryland, Baltimore
Daniel G. Tenen
Daniel G. Tenen National University of Singapore
H. Phillip Koeffler
H. Phillip Koeffler Cedars-Sinai Medical Center
Adrian F. Gombart
Adrian F. Gombart Oregon State University
Linzhao Cheng
Linzhao Cheng Chinese Academy of Sciences
Scott W. Hiebert
Scott W. Hiebert Vanderbilt University
David Gonzalez
David Gonzalez University of California, San Diego
Leslie Cope
Leslie Cope Johns Hopkins University School of Medicine
Jay L. Hess
Jay L. Hess Indiana University
Nancy A. Speck
Nancy A. Speck University of Pennsylvania

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