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Keith G. Mansfield

Keith G. Mansfield

D-Index & Metrics

Immunology

D-Index
64
Citations
15876
World Ranking
2922
National Ranking
72

Overview

Keith G. Mansfield is affiliated with Novartis (Switzerland) and focuses primarily on medicine, with a particular emphasis on oncology, immunology, genetics, molecular biology, and infectious diseases. Their research portfolio spans 38 publications within these fields, highlighting a multidisciplinary approach to biomedical science.

Their work covers diverse topics, including:

  • CAR-T cell therapy research
  • Immunotherapy and Immune Responses
  • Neurogenetic and Muscular Disorders Research
  • HER2/EGFR in Cancer Research
  • Monoclonal and Polyclonal Antibodies Research
  • Viral Infectious Diseases and Gene Expression in Insects
  • Virus-based gene therapy research

Mansfield has contributed to research published in several prominent scientific venues, among which the most frequent include:

  • Molecular Therapy (4 publications)
  • Toxicologic Pathology (3 publications)
  • Blood (2 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (2 publications)
  • Research Square (Research Square) (2 publications)

Key recent papers authored by Mansfield include:

  • "Colon stroma mediates an inflammation-driven fibroblastic response controlling matrix remodeling and healing," 2022, PLoS Biology
  • "Anti-BCMA/CD19 CAR T Cells with Early Immunomodulatory Maintenance for Multiple Myeloma Responding to Initial or Later-Line Therapy," 2022, Blood Cancer Discovery
  • "Two cases of severe pulmonary toxicity from highly active mesothelin-directed CAR T cells," 2023, Molecular Therapy
  • "Intrathecal sc-AAV9-CB-GFP: Systemic Distribution Predominates Following Single-Dose Administration in Cynomolgus Macaques," 2022, Toxicologic Pathology
  • "Single-Dose Intrathecal Dorsal Root Ganglia Toxicity of Onasemnogene Abeparvovec in Cynomolgus Monkeys," 2022, Human Gene Therapy

Frequent collaborators with whom Mansfield has co-authored multiple papers include:

  • Emily K. Meseck (6 joint publications)
  • Brian Granda (4 joint publications)
  • Angelo L. Grauel (3 joint publications)
  • Viviana Cremasco (3 joint publications)
  • Jennifer L. Brogdon (3 joint publications)

Mansfield's research interests reveal a focus on cellular immunotherapy techniques, especially CAR-T cell therapies targeting malignancies such as multiple myeloma. The work on neurogenetic and muscular disorders aligns with investigations into gene therapy vectors and related toxicological assessments in preclinical models. Their ongoing publication record in high-impact journals and specialized venues reflects engagement with complex molecular and immunological mechanisms relevant to current medical challenges.

Best Publications

  • A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma.

    Donald M. O’Rourke;MacLean P. Nasrallah;Arati Desai;Jan J. Melenhorst

  • Comparative Seroprevalence and Immunogenicity of Six Rare Serotype Recombinant Adenovirus Vaccine Vectors from Subgroups B and D

    Peter Abbink;Angelique A. C. Lemckert;Bonnie A. Ewald;Diana M. Lynch

  • Hexon-chimaeric adenovirus serotype 5 vectors circumvent pre-existing anti-vector immunity

    Diane M. Roberts;Anjali Nanda;Menzo J. E. Havenga;Peter Abbink

  • Immune Control of an SIV Challenge by a T Cell-Based Vaccine in Rhesus Monkeys

    Jinyan Liu;Kara L. O’Brien;Diana M. Lynch;Nathaniel L. Simmons

  • Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys

    Dan H. Barouch;Dan H. Barouch;Jinyan Liu;Hualin Li;Lori F. Maxfield

  • Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys

    Dan H. Barouch;Dan H. Barouch;Kara L. O'Brien;Nathaniel L. Simmons;Sharon L. King

  • International Seroepidemiology of Adenovirus Serotypes 5, 26, 35, and 48 in Pediatric and Adult Populations

    Dan H. Barouch;Dan H. Barouch;Sandra V. Kik;Gerrit J. Weverling;Rebecca Dilan

  • Pathogenic Simian Immunodeficiency Virus Infection Is Associated with Expansion of the Enteric Virome

    Scott A. Handley;Larissa B. Thackray;Guoyan Zhao;Rachel Presti

  • A herpesvirus of rhesus monkeys related to the human Kaposi's sarcoma-associated herpesvirus.

    R C Desrosiers;V G Sasseville;S C Czajak;X Zhang

  • Identifying the Target Cell in Primary Simian Immunodeficiency Virus (SIV) Infection: Highly Activated Memory CD4+ T Cells Are Rapidly Eliminated in Early SIV Infection In Vivo

    Ronald S. Veazey;Irene C. Tham;Keith G. Mansfield;MaryAnn DeMaria

  • Dynamics of CCR5 Expression by CD4+ T Cells in Lymphoid Tissues during Simian Immunodeficiency Virus Infection

    Ronald S. Veazey;Keith G. Mansfield;Irene C. Tham;Angela C. Carville

  • Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys.

    Sampa Santra;Hua-Xin Liao;Ruijin Zhang;Mark Muldoon

  • Heart and Skeletal Muscle Are Targets of Dengue Virus Infection

    Doris Martha Salgado;José Miguel Eltit;José Miguel Eltit;Keith Mansfield;César Panqueba

  • The marmoset as a model of aging and age-related diseases

    Suzette D. Tardif;Keith G. Mansfield;Rama Ratnam;Corinna N. Ross

  • Chemokine expression in simian immunodeficiency virus-induced AIDS encephalitis.

    Vito G. Sasseville;Martha M. Smith;Charles R. Mackay;Douglas R. Pauley

  • Clinical Outcome of Henipavirus Infection in Hamsters Is Determined by the Route and Dose of Infection

    Barry Rockx;Douglas Brining;Joshua Kramer;Julie Callison

  • ADCC Develops Over Time during Persistent Infection with Live-Attenuated SIV and Is Associated with Complete Protection against SIV(mac)251 Challenge

    Michael D. Alpert;Jackson D. Harvey;W. Anderson Lauer;R. Keith Reeves

  • Mucosal Priming of Simian Immunodeficiency Virus-Specific Cytotoxic T-Lymphocyte Responses in Rhesus Macaques by the Salmonella Type III Secretion Antigen Delivery System

    David T. Evans;Li Mei Chen;Jacqueline Gillis;Kuei Chin Lin

  • Magnitude and Phenotype of Cellular Immune Responses Elicited by Recombinant Adenovirus Vectors and Heterologous Prime-Boost Regimens in Rhesus Monkeys

    Jinyan Liu;Bonnie A. Ewald;Diana M. Lynch;Matthew Denholtz

  • Trafficking of Antigen-Specific CD8+ T-Lymphocytes to Mucosal Surfaces Following Intramuscular Vaccination

    David R. Kaufman;Jinyan Liu;Angela Carville;Keith G. Mansfield

  • Local replication of simian immunodeficiency virus in the breast milk compartment of chronically-infected, lactating rhesus monkeys

    Sallie Robey Permar;Sallie Robey Permar;Helen H Kang;Andrew B Wilks;Linh Mach

Frequent Co-Authors

Dan H. Barouch
Dan H. Barouch Harvard Medical School
Andrew A. Lackner
Andrew A. Lackner Tulane University
Ronald C. Desrosiers
Ronald C. Desrosiers University of Miami
Peter Abbink
Peter Abbink Harvard Medical School
Jaap Goudsmit
Jaap Goudsmit Harvard University
Norman L. Letvin
Norman L. Letvin Beth Israel Deaconess Medical Center
Sallie R. Permar
Sallie R. Permar Duke University
Jeffrey D. Lifson
Jeffrey D. Lifson Leidos (United States)
R. Paul Johnson
R. Paul Johnson Emory University
Wenjun Li
Wenjun Li University of Massachusetts Chan Medical School

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