World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
15803
World Ranking
12991
National Ranking
230

Overview

John D. McKinney is affiliated with the École Polytechnique Fédérale de Lausanne in Switzerland. Their research primarily focuses on the intersection of medicine, biochemistry, genetics, and molecular biology, with a significant emphasis on infectious diseases and epidemiology.

The scientist's work covers several main topics in biomedical research, including:

  • Tuberculosis Research and Epidemiology
  • Mycobacterium research and diagnosis
  • Urinary Tract Infections Management
  • Urinary Bladder and Prostate Research
  • Bacteriophages and microbial interactions
  • Antibiotic Resistance in Bacteria
  • Bacterial Genetics and Biotechnology

John D. McKinney has contributed to scientific literature with several papers published between 2020 and 2021. Notable publications include:

  • A lung-on-chip model of early Mycobacterium tuberculosis infection reveals an essential role for alveolar epithelial cells in controlling bacterial growth, 2020, eLife
  • Rapid endotheliitis and vascular damage characterize SARS-CoV-2 infection in a human lung-on-chip model, 2021, EMBO Reports
  • Dynamic persistence of UPEC intracellular bacterial communities in a human bladder-chip model of urinary tract infection, 2021, eLife
  • Toilet hygiene-review and research needs, 2021, Journal of Applied Microbiology
  • A biphasic growth model for cell pole elongation in mycobacteria, 2020, Nature Communications

The research has been published in a variety of venues, predominantly featuring contributions in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • eLife
  • Nature Communications
  • Zenodo (CERN European Organization for Nuclear Research)
  • EMBO Reports

Collaborative efforts are evident through frequent co-authors including Neeraj Dhar, Kunal Sharma, Vivek V. Thacker, Chiara Toniolo, and Georg E. Fantner. These collaborations span multiple publications, reflecting a networked approach to advancing knowledge in their fields of study.

The scientist's expertise extends into key subfields such as epidemiology, infectious diseases, molecular biology, biomedical engineering, and genetics. The combination of these domains supports an interdisciplinary research portfolio targeting complex biological and medical challenges.

Best Publications

  • Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase

    John D. McKinney;John D. McKinney;John D. McKinney;Kerstin Höner Zu Bentrup;Kerstin Höner Zu Bentrup;Kerstin Höner Zu Bentrup;Ernesto J. Muñoz-Elias;Andras Miczak;Andras Miczak

  • Immune Control of Tuberculosis by IFN-γ-Inducible LRG-47

    John D. MacMicking;Gregory A. Taylor;Gregory A. Taylor;John D. McKinney

  • Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis

    Vadim Makarov;Giulia Manina;Katarina Mikusova;Ute Möllmann

  • Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence

    Ernesto J Muñoz-Elías;John D McKinney

  • M. tuberculosis persistence, latency, and drug tolerance

    James E Gomez;John D McKinney

  • Dynamic Persistence of Antibiotic-Stressed Mycobacteria

    Yuichi Wakamoto;Neeraj Dhar;Remy Chait;Katrin Schneider

  • Microbial phenotypic heterogeneity and antibiotic tolerance.

    Neeraj Dhar;John D McKinney

  • Role of KatG catalase-peroxidase in mycobacterial pathogenesis: countering the phagocyte oxidative burst

    Vincent H. Ng;Jeffery S. Cox;Alexandra O. Sousa;John D. MacMicking

  • Role of the methylcitrate cycle in Mycobacterium tuberculosis metabolism, intracellular growth, and virulence

    Ernesto J Muñoz-Elías;Anna M Upton;Joseph Cherian;John D McKinney

  • Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis

    V. Sharma;S. Sharma;K. Hoener zu Bentrup;J.D. McKinney

  • Differential expression of iron-, carbon-, and oxygen-responsive mycobacterial genes in the lungs of chronically infected mice and tuberculosis patients

    Juliano Timm;Frank A. Post;Linda-Gail Bekker;Gabriele B. Walther

  • Carbon metabolism of intracellular bacteria.

    Ernesto J. Muñoz‐Elías;John D. McKinney

  • A problem of persistence: still more questions than answers?

    Nathalie Q. Balaban;Kenn Gerdes;Kim Lewis;John D. McKinney

  • Stress and Host Immunity Amplify Mycobacterium tuberculosis Phenotypic Heterogeneity and Induce Nongrowing Metabolically Active Forms

    Giulia Manina;Neeraj Dhar;John D. McKinney

  • Cholesterol catabolism by Mycobacterium tuberculosis requires transcriptional and metabolic adaptations.

    Jennifer E. Griffin;Amit K. Pandey;Sarah A. Gilmore;Valerie Mizrahi

  • Replication dynamics of Mycobacterium tuberculosis in chronically infected mice.

    Ernesto J. Muñoz-Elías;Juliano Timm;Tania Botha;Wai-Tsing Chan

  • Functional Characterization of a Vitamin B12-Dependent Methylmalonyl Pathway in Mycobacterium tuberculosis: Implications for Propionate Metabolism during Growth on Fatty Acids

    Suzana Savvi;Digby F. Warner;Bavesh D. Kana;John D. McKinney

  • Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism

    Anil Koul;Luc Vranckx;Neeraj Dhar;Hinrich W H Göhlmann

  • Dual Role of Isocitrate Lyase 1 in the Glyoxylate and Methylcitrate Cycles in Mycobacterium Tuberculosis

    Ty A. Gould;Helmus Van De Langemheen;Ernesto J. Muñoz‐Elías;John D. McKinney

  • Targeting bacterial central metabolism for drug development.

    Paul Murima;John D. McKinney;Kevin Pethe;Kevin Pethe

Frequent Co-Authors

Georg E. Fantner
Georg E. Fantner École Polytechnique Fédérale de Lausanne
Thomas R. Ioerger
Thomas R. Ioerger Texas A&M University
James C. Sacchettini
James C. Sacchettini Texas A&M University
William R. Jacobs
William R. Jacobs Albert Einstein College of Medicine
David G. Russell
David G. Russell Cornell University
Frederick R. Cross
Frederick R. Cross Rockefeller University
Stewart T. Cole
Stewart T. Cole Institut Pasteur
Barry R. Bloom
Barry R. Bloom Harvard University
Philippe Renaud
Philippe Renaud École Polytechnique Fédérale de Lausanne
Nathaniel Heintz
Nathaniel Heintz Rockefeller University

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