World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
48
Citations
9006
World Ranking
18352
National Ranking
7493

Overview

Katheryn Meek is affiliated with Michigan State University in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant contributions in molecular biology, structural biology, plant science, materials chemistry, and oncology. The scientist has engaged extensively with topics such as DNA repair mechanisms, CRISPR and genetic engineering, DNA and nucleic acid chemistry, RNA and protein synthesis mechanisms, enzyme structure and function, advanced electron microscopy techniques and applications, and chromosomal and genetic variations.

Meek has participated in multiple publications across various scientific journals. Frequent venues for their work include Molecular Cell, Nucleic Acids Research, DNA Repair, Nature Communications, and bioRxiv (Cold Spring Harbor Laboratory). These platforms reflect a concentration in molecular and genetic research.

Recent published papers by Meek include:

  • Cryo-EM of NHEJ supercomplexes provides insights into DNA repair (2021, Molecular Cell)
  • Autophosphorylation transforms DNA-PK from protecting to processing DNA ends (2021, Molecular Cell)
  • Uncovering DNA-PKcs ancient phylogeny, unique sequence motifs and insights for human disease (2020, Progress in Biophysics and Molecular Biology)
  • Two distinct long-range synaptic complexes promote different aspects of end processing prior to repair of DNA breaks by non-homologous end joining (2023, Molecular Cell)
  • PAXX binding to the NHEJ machinery explains functional redundancy with XLF (2023, Science Advances)

Meek has collaborated frequently with several researchers including Noah J. Goff, Steven W. Hardwick, Tom L. Blundell, Amanda K. Chaplin, and Christopher J. Buehl. These coauthors have appeared in multiple joint publications, reflecting ongoing collaborative efforts in their field.

The primary research fields covered by Meek amount to 43 publications within biochemistry, genetics, and molecular biology. Their work is highly specialized in molecular biology with 39 publications, and they have also contributed to plant science, materials chemistry, structural biology, and oncology. The scholar's research contributions emphasize various aspects of DNA repair mechanisms, gene editing techniques including CRISPR, and molecular level interactions of nucleic acids and proteins.

Best Publications

  • Repair of ionizing radiation-induced DNA double strand breaks by non-homologous end-joining

    Brandi L. Mahaney;Katheryn Meek;Susan P. Lees-Miller;Susan P. Lees-Miller

  • Repair of DNA double strand breaks by non-homologous end joining.

    S. P. Lees-Miller;K. Meek

  • Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair.

    Qi Ding;Yeturu V. R. Reddy;Wei Wang;Timothy Woods

  • Rag mutations reveal robust alternative end joining

    Barbara Corneo;Rebecca L. Wendland;Ludovic Deriano;Xiaoping Cui

  • DNA-PK: the means to justify the ends?

    Katheryn Meek;Van Dang;Susan P. Lees-Miller

  • Autophosphorylation of DNA-Dependent Protein Kinase Regulates DNA End Processing and May Also Alter Double-Strand Break Repair Pathway Choice†

    Xiaoping Cui;Yaping Yu;Shikha Gupta;Young-Moon Cho

  • The DNA-dependent protein kinase: the director at the end.

    Katheryn Meek;Shikha Gupta;Dale A. Ramsden;Susan P. Lees-Miller

  • trans autophosphorylation at DNA-dependent protein kinase's two major autophosphorylation site clusters facilitates end processing but not end joining

    Katheryn Meek;Pauline Douglas;Xiaoping Cui;Qi Ding

  • Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase

    Pauline Douglas;Gopal P Sapkota;Nick Morrice;Yaping Yu

  • A kinase-negative mutation of DNA-PK(CS) in equine SCID results in defective coding and signal joint formation.

    Euy Kyun Shin;Lance E. Perryman;Katheryn Meek

  • Chapter 2 DNA-PK

    Katheryn Meek;Van Dang;Susan P. Lees-Miller

  • Non-homologous end joining requires that the DNA-PK complex undergo an autophosphorylation-dependent rearrangement at DNA ends.

    Yeturu V.R. Reddy;Qi Ding;Susan P. Lees-Miller;Katheryn Meek

  • Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends

    Wesley D. Block;Yaping Yu;Dennis Merkle;Jessica L. Gifford

  • DNA–PKcs function regulated specifically by protein phosphatase 5

    Thomas Wechsler;Benjamin P. C. Chen;Ryan Harper;Keiko Morotomi-Yano

  • Equine severe combined immunodeficiency: a defect in V(D)J recombination and DNA-dependent protein kinase activity

    Rhonda Wiler;Ray Leber;Bethany B. Moore;Linda F. Vandyk

  • The DNA-Dependent Protein Kinase Catalytic Subunit Is Phosphorylated In Vivo on Threonine 3950, a Highly Conserved Amino Acid in the Protein Kinase Domain

    Pauline Douglas;Xiaoping Cui;Wesley D. Block;Yaping Yu

  • Inhibition of homologous recombination by DNA-dependent protein kinase requires kinase activity, is titratable, and is modulated by autophosphorylation.

    Jessica A. Neal;Van Dang;Pauline Douglas;Marc S. Wold

  • DNA-PK phosphorylation sites in XRCC4 are not required for survival after radiation or for V(D)J recombination

    Yaping Yu;Wei Wang;Qi Ding;Ruiqiong Ye

  • Roles of host cell factors in circularization of retroviral dna.

    Jennifer M. Kilzer;Travis Stracker;Brett Beitzel;Katheryn Meek

  • T cell receptor V beta gene bias in rheumatoid arthritis.

    R N Jenkins;A Nikaein;A Zimmermann;K Meek

Frequent Co-Authors

Bethany B. Moore
Bethany B. Moore University of Michigan–Ann Arbor
J D Capra
J D Capra The University of Texas Southwestern Medical Center
Peter E. Lipsky
Peter E. Lipsky National Institutes of Health
Iñaki Sanz
Iñaki Sanz Emory University
Philip W. Tucker
Philip W. Tucker The University of Texas at Austin
Susan P. Lees-Miller
Susan P. Lees-Miller University of Calgary
Constantin A. Bona
Constantin A. Bona Icahn School of Medicine at Mount Sinai
Richard B. Gaynor
Richard B. Gaynor Eli Lilly (United States)
David Roth
David Roth University of Miami
Alfred Nisonoff
Alfred Nisonoff Brandeis University

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