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Jan Paul Medema

Jan Paul Medema

D-Index & Metrics

Medicine

D-Index
90
Citations
42982
World Ranking
11995
National Ranking
463

Overview

Jan Paul Medema is affiliated with Amsterdam UMC in the Netherlands and has made significant contributions in the fields of medicine and biochemistry, genetics, and molecular biology. Their research primarily focuses on oncology, with particular attention to colorectal cancer and cancer-related molecular mechanisms.

The scientist's work spans several subfields including oncology, molecular biology, pathology and forensic medicine, cancer research, and surgery. The main topics covered in their research include genetic factors in colorectal cancer, colorectal cancer treatments and studies, cancer cells and metastasis, pancreatic and hepatic oncology research, cancer genomics and diagnostics, colorectal cancer surgical treatments, and digestive system and related health issues.

Their recent publications highlight several aspects of cancer biology and potential therapeutic strategies. Notable papers include:

  • The Role of Cancer-Associated Fibroblasts in Cancer Invasion and Metastasis, 2021, published in Cancers
  • Apc-mutant cells act as supercompetitors in intestinal tumour initiation, 2021, published in Nature
  • BCL-2 family deregulation in colorectal cancer: potential for BH3 mimetics in therapy, 2020, published in APOPTOSIS
  • Molecular characterization of colorectal cancer related peritoneal metastatic disease, 2022, published in Nature Communications
  • PI3K-driven HER2 expression is a potential therapeutic target in colorectal cancer stem cells, 2021, published in Gut

Jan Paul Medema frequently collaborates with several co-authors, including Jan Köster, Maarten F. Bijlsma, Louis Vermeulen, Arezo Torang, and Hanneke W.M. van Laarhoven. Their publication record is concentrated in notable venues such as Nature Communications, bioRxiv (Cold Spring Harbor Laboratory), Cancers, BMC Cancer, and Research Square.

Their body of work encompasses a total of 131 publications within the broader medical field and 55 in biochemistry, genetics, and molecular biology. Oncology accounts for the majority of their contributions, underscoring a consistent focus on cancer biology and treatment research.

Best Publications

  • The consensus molecular subtypes of colorectal cancer

    Justin Guinney;Rodrigo Dienstmann;Rodrigo Dienstmann;Xingwu Wang;Xingwu Wang;Aurélien De Reyniès

  • FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).

    Jan Paul Medema;Carsten Scaffidi;Frank C. Kischkel;Andrej Shevchenko

  • Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4.

    Matilde Todaro;Mileidys Perez Alea;Anna B. Di Stefano;Patrizia Cammareri

  • Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

    L. Galluzzi;J. M. Bravo-San Pedro;I. Vitale;S. A. Aaronson

  • Sequential cancer mutations in cultured human intestinal stem cells

    Jarno Drost;Richard H. van Jaarsveld;Bas Ponsioen;Cheryl Zimberlin

  • Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes

    L. Galluzzi;L. Galluzzi;L. Galluzzi;S. A. Aaronson;J. Abrams;E. S. Alnemri

  • Elucidating the Autoimmune and Antitumor Effector Mechanisms of a Treatment Based on Cytotoxic T Lymphocyte Antigen-4 Blockade in Combination with a B16 Melanoma Vaccine Comparison of Prophylaxis and Therapy

    A. Van Elsas;R. P M Sutmuller;A. A. Hurwitz;J. Ziskin

  • The AC133 Epitope, but not the CD133 Protein, Is Lost upon Cancer Stem Cell Differentiation

    Kristel Kemper;Martin R. Sprick;Martijn de Bree;Alessandro Scopelliti

  • Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors

    J. P. Medema;J. de Jong;L. T. C. Peltenburg;E. M. E. Verdegaal

  • Immune escape of tumors in vivo by expression of cellular FLICE-inhibitory protein.

    J. P. Medema;J. De Jong;T. Van Hall;C. J. M. Melief

  • Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis.

    Rene Jackstadt;Sander R. van Hooff;Joshua D. Leach;Xabier Cortes-Lavaud

  • Methylation of Cancer-Stem-Cell-Associated Wnt Target Genes Predicts Poor Prognosis in Colorectal Cancer Patients

    Felipe de Sousa E Melo;Selcuk Colak;Joyce Buikhuisen;Jan Koster

  • APRIL modulates B and T cell immunity.

    Jens V. Stein;Marta López-Fraga;Fernando A. Elustondo;Carla E. Carvalho-Pinto

  • CD40 stimulation leads to effective therapy of CD40(-) tumors through induction of strong systemic cytotoxic T lymphocyte immunity.

    Geertje J. D. van Mierlo;Annemieke Th. den Boer;Jan Paul Medema;Ellen I. H. van der Voort

  • Granzyme B-Dependent Proteolysis Acts as a Switch to Enhance the Proinflammatory Activity of IL-1α

    Inna S. Afonina;Graham A. Tynan;Susan E. Logue;Sean P. Cullen

  • Expression of the serpin serine protease inhibitor 6 protects dendritic cells from cytotoxic T lymphocyte-induced apoptosis: differential modulation by T helper type 1 and type 2 cells.

    Jan Paul Medema;Danita H. Schuurhuis;Delphine Rea;Joost van Tongeren

  • Monoclonal Antibodies Against Lgr5 Identify Human Colorectal Cancer Stem Cells

    Kristel Kemper;Pramudita R. Prasetyanti;Wim De Lau;Hans Rodermond

  • Heparan sulfate proteoglycan binding promotes APRIL-induced tumor cell proliferation

    J Hendriks;L Planelles;J de Jong-Odding;G Hardenberg

  • Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer: a retrospective, pooled biomarker study

    Enric Domingo;Enric Domingo;Luke Freeman-Mills;Emily Rayner;Mark Glaire

  • Strategies for immunotherapy of cancer

    C J Melief;R E Toes;J P Medema;S H van der Burg

Frequent Co-Authors

Michael Hahne
Michael Hahne Centre national de la recherche scientifique, CNRS
Carlos Martínez-A
Carlos Martínez-A Spanish National Research Council
Wilson Savino
Wilson Savino Oswaldo Cruz Foundation
Marcel Spaargaren
Marcel Spaargaren University of Amsterdam
Eric Eldering
Eric Eldering University of Amsterdam
Tom van der Poll
Tom van der Poll University of Amsterdam

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