World's Best Scientists 2026 revealed!
Jan Paul Medema

Jan Paul Medema

D-Index & Metrics

Medicine

D-Index
90
Citations
42982
World Ranking
11995
National Ranking
463

Jan Paul Medema publication distribution in Medicine in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Medicine in 2026. The highlighted bar marks where Jan Paul Medema sits on this spectrum.

101–120 publications: 5 scientists 121–140 publications: 26 scientists 141–160 publications: 73 scientists 161–180 publications: 155 scientists 181–200 publications: 230 scientists 201–220 publications: 363 scientists 221–240 publications: 487 scientists 241–260 publications: 545 scientists 261–280 publications: 722 scientists 281–300 publications: 768 scientists 301–320 publications: 834 scientists 321–340 publications: 895 scientists 341–360 publications: 922 scientists 361–380 publications: 838 scientists 381–400 publications: 861 scientists 401–420 publications: 918 scientists 421–440 publications: 806 scientists 441–460 publications: 771 scientists 461–480 publications: 751 scientists 481–500 publications: 713 scientists 501–520 publications: 617 scientists 521–540 publications: 611 scientists 541–560 publications: 537 scientists 561–580 publications: 504 scientists 581–600 publications: 509 scientists 601–620 publications: 396 scientists 621–640 publications: 386 scientists 641–660 publications: 371 scientists 661–680 publications: 340 scientists 681–700 publications: 336 scientists 701–720 publications: 307 scientists 721–740 publications: 259 scientists 741–760 publications: 230 scientists 761–780 publications: 228 scientists 781–800 publications: 217 scientists 801–820 publications: 204 scientists 821–840 publications: 186 scientists 841–860 publications: 177 scientists 861–880 publications: 155 scientists 881–900 publications: 139 scientists 901–920 publications: 145 scientists 921–940 publications: 116 scientists 941–960 publications: 133 scientists 961–980 publications: 91 scientists 981–1,000 publications: 96 scientists 1,001–1,020 publications: 77 scientists 1,021–1,040 publications: 70 scientists 1,041–1,060 publications: 63 scientists 1,061–1,080 publications: 77 scientists 1,081–1,100 publications: 49 scientists 1,101–1,120 publications: 54 scientists 1,121–1,140 publications: 49 scientists 1,141–1,160 publications: 51 scientists 1,161–1,180 publications: 35 scientists 1,181–1,200 publications: 39 scientists 1,201–1,220 publications: 26 scientists 1,221–1,240 publications: 37 scientists 1,241–1,260 publications: 36 scientists 1,261–1,280 publications: 27 scientists 1,281–1,300 publications: 32 scientists 1,301–1,320 publications: 28 scientists 1,321–1,340 publications: 17 scientists 1,341–1,360 publications: 30 scientists 1,361–1,380 publications: 28 scientists 1,381–1,400 publications: 17 scientists 1,401–1,420 publications: 21 scientists 1,421–1,440 publications: 15 scientists 1,441–1,460 publications: 12 scientists 1,461–1,480 publications: 12 scientists 1,481–1,500 publications: 18 scientists 1,501–1,520 publications: 14 scientists 1,521–1,540 publications: 17 scientists 1,541–1,560 publications: 15 scientists 1,561–1,580 publications: 6 scientists 1,581–1,600 publications: 2 scientists 1,601–1,620 publications: 12 scientists 1,621–1,640 publications: 11 scientists 1,641–1,660 publications: 8 scientists 1,661–1,680 publications: 5 scientists 1,681–1,700 publications: 5 scientists 1,701–1,720 publications: 10 scientists 1,721–1,740 publications: 12 scientists 1,741–1,760 publications: 14 scientists 1,761–1,780 publications: 6 scientists 1,781–1,795 publications: 5 scientists 1,796+ publications: 100 scientists
101 publications 1,796+

This scientist: 409 publications — 40th percentile

40% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,796 publications or more.

Jan Paul Medema D-index placement in Medicine in 2026

The chart shows the D-index (discipline H-index) distribution of Medicine scientists ranked by Research.com in 2026. The highlighted bar marks where Jan Paul Medema sits on this spectrum.

70–71 D-Index: 226 scientists 72–73 D-Index: 391 scientists 74–75 D-Index: 574 scientists 76–77 D-Index: 730 scientists 78–79 D-Index: 891 scientists 80–81 D-Index: 972 scientists 82–83 D-Index: 1,027 scientists 84–85 D-Index: 1,003 scientists 86–87 D-Index: 960 scientists 88–89 D-Index: 970 scientists 90–91 D-Index: 922 scientists 92–93 D-Index: 839 scientists 94–95 D-Index: 808 scientists 96–97 D-Index: 779 scientists 98–99 D-Index: 668 scientists 100–101 D-Index: 611 scientists 102–103 D-Index: 630 scientists 104–105 D-Index: 513 scientists 106–107 D-Index: 541 scientists 108–109 D-Index: 445 scientists 110–111 D-Index: 429 scientists 112–113 D-Index: 400 scientists 114–115 D-Index: 393 scientists 116–117 D-Index: 318 scientists 118–119 D-Index: 302 scientists 120–121 D-Index: 287 scientists 122–123 D-Index: 255 scientists 124–125 D-Index: 256 scientists 126–127 D-Index: 252 scientists 128–129 D-Index: 230 scientists 130–131 D-Index: 179 scientists 132–133 D-Index: 168 scientists 134–135 D-Index: 163 scientists 136–137 D-Index: 159 scientists 138–139 D-Index: 134 scientists 140–141 D-Index: 134 scientists 142–143 D-Index: 118 scientists 144–145 D-Index: 109 scientists 146–147 D-Index: 106 scientists 148–149 D-Index: 74 scientists 150–151 D-Index: 79 scientists 152–153 D-Index: 80 scientists 154–155 D-Index: 87 scientists 156–157 D-Index: 57 scientists 158–159 D-Index: 74 scientists 160–161 D-Index: 69 scientists 162–163 D-Index: 60 scientists 164–165 D-Index: 53 scientists 166–167 D-Index: 39 scientists 168–169 D-Index: 42 scientists 170–171 D-Index: 32 scientists 172–173 D-Index: 39 scientists 174–175 D-Index: 40 scientists 176–177 D-Index: 28 scientists 178–179 D-Index: 19 scientists 180–181 D-Index: 23 scientists 182–183 D-Index: 31 scientists 184–185 D-Index: 18 scientists 186–187 D-Index: 20 scientists 188–189 D-Index: 22 scientists 190–191 D-Index: 13 scientists 192–193 D-Index: 21 scientists 194–195 D-Index: 12 scientists 196–197 D-Index: 12 scientists 198–199 D-Index: 14 scientists 200–201 D-Index: 15 scientists 202–203 D-Index: 13 scientists 204–205 D-Index: 10 scientists 206–207 D-Index: 8 scientists 208–209 D-Index: 4 scientists 210–211 D-Index: 12 scientists 212–213 D-Index: 11 scientists 214–215 D-Index: 10 scientists 216 D-Index: 4 scientists 217+ D-Index: 98 scientists
70 D-Index 217+

This scientist: 90 D-Index — 41st percentile

41% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 217 D-Index or more.

Overview

Jan Paul Medema is affiliated with Amsterdam UMC in the Netherlands and has made significant contributions in the fields of medicine and biochemistry, genetics, and molecular biology. Their research primarily focuses on oncology, with particular attention to colorectal cancer and cancer-related molecular mechanisms.

The scientist's work spans several subfields including oncology, molecular biology, pathology and forensic medicine, cancer research, and surgery. The main topics covered in their research include genetic factors in colorectal cancer, colorectal cancer treatments and studies, cancer cells and metastasis, pancreatic and hepatic oncology research, cancer genomics and diagnostics, colorectal cancer surgical treatments, and digestive system and related health issues.

Their recent publications highlight several aspects of cancer biology and potential therapeutic strategies. Notable papers include:

  • The Role of Cancer-Associated Fibroblasts in Cancer Invasion and Metastasis, 2021, published in Cancers
  • Apc-mutant cells act as supercompetitors in intestinal tumour initiation, 2021, published in Nature
  • BCL-2 family deregulation in colorectal cancer: potential for BH3 mimetics in therapy, 2020, published in APOPTOSIS
  • Molecular characterization of colorectal cancer related peritoneal metastatic disease, 2022, published in Nature Communications
  • PI3K-driven HER2 expression is a potential therapeutic target in colorectal cancer stem cells, 2021, published in Gut

Jan Paul Medema frequently collaborates with several co-authors, including Jan Köster, Maarten F. Bijlsma, Louis Vermeulen, Arezo Torang, and Hanneke W.M. van Laarhoven. Their publication record is concentrated in notable venues such as Nature Communications, bioRxiv (Cold Spring Harbor Laboratory), Cancers, BMC Cancer, and Research Square.

Their body of work encompasses a total of 131 publications within the broader medical field and 55 in biochemistry, genetics, and molecular biology. Oncology accounts for the majority of their contributions, underscoring a consistent focus on cancer biology and treatment research.

Best Publications

  • The consensus molecular subtypes of colorectal cancer

    Justin Guinney;Rodrigo Dienstmann;Rodrigo Dienstmann;Xingwu Wang;Xingwu Wang;Aurélien De Reyniès

  • FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).

    Jan Paul Medema;Carsten Scaffidi;Frank C. Kischkel;Andrej Shevchenko

  • Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4.

    Matilde Todaro;Mileidys Perez Alea;Anna B. Di Stefano;Patrizia Cammareri

  • Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

    L. Galluzzi;J. M. Bravo-San Pedro;I. Vitale;S. A. Aaronson

  • Sequential cancer mutations in cultured human intestinal stem cells

    Jarno Drost;Richard H. van Jaarsveld;Bas Ponsioen;Cheryl Zimberlin

  • Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes

    L. Galluzzi;L. Galluzzi;L. Galluzzi;S. A. Aaronson;J. Abrams;E. S. Alnemri

  • Elucidating the Autoimmune and Antitumor Effector Mechanisms of a Treatment Based on Cytotoxic T Lymphocyte Antigen-4 Blockade in Combination with a B16 Melanoma Vaccine Comparison of Prophylaxis and Therapy

    A. Van Elsas;R. P M Sutmuller;A. A. Hurwitz;J. Ziskin

  • The AC133 Epitope, but not the CD133 Protein, Is Lost upon Cancer Stem Cell Differentiation

    Kristel Kemper;Martin R. Sprick;Martijn de Bree;Alessandro Scopelliti

  • Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors

    J. P. Medema;J. de Jong;L. T. C. Peltenburg;E. M. E. Verdegaal

  • Immune escape of tumors in vivo by expression of cellular FLICE-inhibitory protein.

    J. P. Medema;J. De Jong;T. Van Hall;C. J. M. Melief

  • Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis.

    Rene Jackstadt;Sander R. van Hooff;Joshua D. Leach;Xabier Cortes-Lavaud

  • Methylation of Cancer-Stem-Cell-Associated Wnt Target Genes Predicts Poor Prognosis in Colorectal Cancer Patients

    Felipe de Sousa E Melo;Selcuk Colak;Joyce Buikhuisen;Jan Koster

  • APRIL modulates B and T cell immunity.

    Jens V. Stein;Marta López-Fraga;Fernando A. Elustondo;Carla E. Carvalho-Pinto

  • CD40 stimulation leads to effective therapy of CD40(-) tumors through induction of strong systemic cytotoxic T lymphocyte immunity.

    Geertje J. D. van Mierlo;Annemieke Th. den Boer;Jan Paul Medema;Ellen I. H. van der Voort

  • Granzyme B-Dependent Proteolysis Acts as a Switch to Enhance the Proinflammatory Activity of IL-1α

    Inna S. Afonina;Graham A. Tynan;Susan E. Logue;Sean P. Cullen

  • Expression of the serpin serine protease inhibitor 6 protects dendritic cells from cytotoxic T lymphocyte-induced apoptosis: differential modulation by T helper type 1 and type 2 cells.

    Jan Paul Medema;Danita H. Schuurhuis;Delphine Rea;Joost van Tongeren

  • Monoclonal Antibodies Against Lgr5 Identify Human Colorectal Cancer Stem Cells

    Kristel Kemper;Pramudita R. Prasetyanti;Wim De Lau;Hans Rodermond

  • Heparan sulfate proteoglycan binding promotes APRIL-induced tumor cell proliferation

    J Hendriks;L Planelles;J de Jong-Odding;G Hardenberg

  • Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer: a retrospective, pooled biomarker study

    Enric Domingo;Enric Domingo;Luke Freeman-Mills;Emily Rayner;Mark Glaire

  • Strategies for immunotherapy of cancer

    C J Melief;R E Toes;J P Medema;S H van der Burg

Frequent Co-Authors

Michael Hahne
Michael Hahne Centre national de la recherche scientifique, CNRS
Carlos Martínez-A
Carlos Martínez-A Spanish National Research Council
Wilson Savino
Wilson Savino Oswaldo Cruz Foundation
Marcel Spaargaren
Marcel Spaargaren University of Amsterdam
Eric Eldering
Eric Eldering University of Amsterdam
Tom van der Poll
Tom van der Poll University of Amsterdam

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