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Biology and Biochemistry

D-Index
56
Citations
9340
World Ranking
14620
National Ranking
355

Overview

Eric Eldering is affiliated with the University of Amsterdam in the Netherlands, contributing extensively to the fields of Medicine and Biochemistry, Genetics, and Molecular Biology. Their research spans several subfields including Genetics, Immunology, Molecular Biology, Pathology and Forensic Medicine, and Oncology.

The scientist's work primarily focuses on topics related to Chronic Lymphocytic Leukemia Research, with significant contributions to Lymphoma Diagnosis and Treatment, as well as CAR-T cell therapy research. Additional research interests include Immunodeficiency and Autoimmune Disorders, Monoclonal and Polyclonal Antibodies Research, and Immunotherapy and Immune Responses, alongside Acute Lymphoblastic Leukemia Research.

Eric Eldering's recent publications highlight involvement in studies concentrating on mechanisms, treatment resistance, and immune response in hematological malignancies. Selected recent papers include:

  • Venetoclax Plus Rituximab in Relapsed Chronic Lymphocytic Leukemia: 4-Year Results and Evaluation of Impact of Genomic Complexity and Gene Mutations From the MURANO Phase III Study (2020, Journal of Clinical Oncology)
  • Changes in Bcl-2 members after ibrutinib or venetoclax uncover functional hierarchy in determining resistance to venetoclax in CLL (2020, Blood)
  • Starvation and antimetabolic therapy promote cytokine release and recruitment of immune cells (2020, Proceedings of the National Academy of Sciences)
  • Regulation of Bcl-XL by non-canonical NF-κB in the context of CD40-induced drug resistance in CLL (2021, Cell Death and Differentiation)
  • Genomic arrays identify high-risk chronic lymphocytic leukemia with genomic complexity: a multi-center study (2020, Haematologica)

Frequent collaborators include Arnon P. Kater, Gaspard Cretenet, Marco V. Haselager, Fleur S. Peters, and Helga Simon-Molas, with collaboration counts ranging from 12 to 48 joint works. This network indicates a consistent pattern of partnerships in research projects.

Eric Eldering has contributed to multiple publications in specialized journals, often appearing in:

  • Blood
  • Haematologica
  • Blood Advances
  • HemaSphere
  • Molecular Oncology

Best Publications

  • The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia

    Martin F. M. de Rooij;Annemieke Kuil;Christian R. Geest;Eric Eldering

  • CD20 deficiency in humans results in impaired T cell–independent antibody responses

    Taco W. Kuijpers;Richard J. Bende;Paul A. Baars;Annette Grummels

  • miR-34a as Part of the Resistance Network in Chronic Lymphocytic Leukemia

    Thorsten Zenz;Julia Mohr;Eric Eldering;Arnon P. Kater

  • Histone Deacetylase Inhibitors Suppress Inflammatory Activation of Rheumatoid Arthritis Patient Synovial Macrophages and Tissue

    Aleksander M. Grabiec;Sarah Krausz;Wilco de Jager;Tomasz Burakowski

  • Expression profiling via novel multiplex assay allows rapid assessment of gene regulation in defined signalling pathways

    Eric Eldering;C. Arnold Spek;Hella L. Aberson;Annette Grummels

  • The Noxa/Mcl-1 axis regulates susceptibility to apoptosis under glucose limitation in dividing T cells.

    Nuno L. Alves;Ingrid A.M. Derks;Erik Berk;René Spijker

  • Differential Noxa/Mcl-1 balance in peripheral versus lymph node chronic lymphocytic leukemia cells correlates with survival capacity.

    Laura A. Smit;Delfine Y.H. Hallaert;René Spijker;Bart de Goeij

  • APRIL promotes B-1 cell-associated neoplasm

    Lourdes Planelles;Lourdes Planelles;Carla E. Carvalho-Pinto;Carla E. Carvalho-Pinto;Gijs Hardenberg;Salette Smaniotto

  • Venetoclax Plus Rituximab in Relapsed Chronic Lymphocytic Leukemia: 4-Year Results and Evaluation of Impact of Genomic Complexity and Gene Mutations From the MURANO Phase III Study

    Arnon P. Kater;Jenny Qun Wu;Thomas J. Kipps;Barbara Eichhorst

  • IL-21 and CD40L signals from autologous T cells can induce antigen-independent proliferation of CLL cells

    Maria Fernanda Pascutti;Margot Jak;Jacqueline M. Tromp;Ingrid A. M. Derks

  • CD27-CD70 interactions sensitise naive CD4+ T cells for IL-12-induced Th1 cell development.

    Michiel F. van Oosterwijk;Hedi Juwana;Ramon Arens;Kiki Tesselaar

  • Potentiation of C1 inhibitor by glycosaminoglycans: dextran sulfate species are effective inhibitors of in vitro complement activation in plasma.

    W.A. Wuillemin;H. te Velthuis;Y.T.P. Lubbers;C.P. de Ruig

  • c-Abl kinase inhibitors overcome CD40-mediated drug resistance in CLL: implications for therapeutic targeting of chemoresistant niches

    Delfine Y. H. Hallaert;Annelieke Jaspers;Carel J. van Noesel;Marinus H. J. van Oers

  • Chronic lymphocytic leukemia cells impair mitochondrial fitness in CD8+ T cells and impede CAR T-cell efficacy.

    Jaco A. C. van Bruggen;Anne W. J. Martens;Joseph A. Fraietta;Tom Hofland

  • Resistance to ABT-199 induced by microenvironmental signals in chronic lymphocytic leukemia can be counteracted by CD20 antibodies or kinase inhibitors

    Rachel Thijssen;Erik Slinger;Katinka Weller;Christian R. Geest

  • The Costimulatory Molecule CD27 Maintains Clonally Diverse CD8+ T Cell Responses of Low Antigen Affinity to Protect against Viral Variants

    Klaas P.J.M. van Gisbergen;Paul L. Klarenbeek;Natasja A.M. Kragten;Peter-Paul A. Unger

  • Enhanced formation and survival of CD4+ CD25hi Foxp3+ T-cells in chronic lymphocytic leukemia.

    Margot Jak;Rogier Mous;Ester B. M. Remmerswaal;René Spijker

  • A hinge region mutation in C1-inhibitor (Ala436-->Thr) results in nonsubstrate-like behavior and in polymerization of the molecule.

    K. S. Aulak;E. Eldering;C. E. Hack;Y. P. T. Lubbers

  • Modulation of Contact System Proteases by Glycosaminoglycans SELECTIVE ENHANCEMENT OF THE INHIBITION OF FACTOR XIa

    Walter A. Wuillemin;Eric Eldering;Franca Citarella;Franca Citarella;Cornelis P. de Ruig

  • Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1

    Onno C. Leeksma;Tanja A. E. van Achterberg;Yoshikazu Tsumura;Jiro Toshima

Frequent Co-Authors

René A. W. van Lier
René A. W. van Lier University of Amsterdam
Marcel Spaargaren
Marcel Spaargaren University of Amsterdam
Šárka Pospíšilová
Šárka Pospíšilová Masaryk University
Stephan Stilgenbauer
Stephan Stilgenbauer University of Ulm
Thomas J. Kipps
Thomas J. Kipps University of California, San Diego
Paul P. Tak
Paul P. Tak GlaxoSmithKline (United Kingdom)
Steven T. Pals
Steven T. Pals University of Amsterdam
Hans Pannekoek
Hans Pannekoek University of Amsterdam
Jeffrey C. Rathmell
Jeffrey C. Rathmell Vanderbilt University Medical Center

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