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Biology and Biochemistry

D-Index
53
Citations
13840
World Ranking
15980
National Ranking
387

Overview

Marcel Spaargaren is affiliated with the University of Amsterdam in the Netherlands. Their research output primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions to Oncology, Molecular Biology, Pathology and Forensic Medicine, Genetics, and Hematology.

The scientist's work covers several specialized topics, including:

  • Lymphoma Diagnosis and Treatment
  • Chronic Lymphocytic Leukemia Research
  • Proteoglycans and glycosaminoglycans research
  • Multiple Myeloma Research and Treatments
  • Chemokine receptors and signaling
  • CAR-T cell therapy research
  • Monoclonal and Polyclonal Antibodies Research

Recent scholarly publications by Spaargaren include:

  • "Infection and transmission of SARS-CoV-2 depend on heparan sulfate proteoglycans," 2021, The EMBO Journal
  • "The CXCL12gamma chemokine immobilized by heparan sulfate on stromal niche cells controls adhesion and mediates drug resistance in multiple myeloma," 2021, Journal of Hematology & Oncology
  • "Hepatocyte growth factor/MET and CD44 in colorectal cancer: partners in tumorigenesis and therapy resistance," 2020, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  • "Immune evasion in primary testicular and central nervous system lymphomas: HLA loss rather than 9p24.1/PD-L1/PD-L2 alterations," 2021, Blood
  • "Endothelial ICAM-1 Adhesome Recruits CD44 for Optimal Transcellular Migration of Human CTLs," 2023, The Journal of Immunology

Frequent publication venues for Marcel Spaargaren include:

  • Blood
  • Blood Advances
  • Leukemia
  • Journal of Hematology & Oncology
  • Blood Cancer Journal

The scientist collaborates regularly with other researchers, including:

  • Steven T. Pals
  • Marie José Kersten
  • Hildo C. Lantermans
  • Eric Eldering
  • Annemieke Kuil

Best Publications

  • Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936.

    J J M van Dongen;A W Langerak;M Brüggemann;P A S Evans

  • The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia

    Martin F. M. de Rooij;Annemieke Kuil;Christian R. Geest;Eric Eldering

  • EuroClonality/BIOMED-2 guidelines for interpretation and reporting of Ig/TCR clonality testing in suspected lymphoproliferations

    A. W. Langerak;P. J. T. A. Groenen;M. Brüggemann;K. Beldjord

  • Differential Interaction of the Ras Family GTP-binding Proteins H-Ras, Rap1A, and R-Ras with the Putative Effector Molecules Raf Kinase and Ral-Guanine Nucleotide Exchange Factor*

    Christian Herrmann;Gudrun Horn;Marcel Spaargaren;Alfred Wittinghofer

  • Illegitimate WNT signaling promotes proliferation of multiple myeloma cells

    Patrick W. B. Derksen;Esther Tjin;Helen P. Meijer;Melanie D. Klok

  • Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap

    Marcel Spaargaren;James R. Bischoff

  • Significantly improved PCR-based clonality testing in B-cell malignancies by use of multiple immunoglobulin gene targets: Report of the BIOMED-2 Concerted Action BHM4-CT98-3936

    P. A. S. Evans;Ch Pott;P. J. T. A. Groenen;G. Salles

  • Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma

    Patrick W. B. Derksen;Robert M. J. Keehnen;Ludo M. Evers;Marinus H. J. van Oers

  • Bruton's Tyrosine Kinase and Phospholipase Cγ2 Mediate Chemokine-Controlled B Cell Migration and Homing

    David J.J. de Gorter;Esther A. Beuling;Rogier Kersseboom;Sabine Middendorp

  • The B Cell Antigen Receptor Controls Integrin Activity through Btk and PLCγ2

    Marcel Spaargaren;Esther A. Beuling;Mette L. Rurup;Helen P. Meijer

  • Heparan sulfate proteoglycan binding promotes APRIL-induced tumor cell proliferation

    J Hendriks;L Planelles;J de Jong-Odding;G Hardenberg

  • Heparan Sulfate-modified CD44 Promotes Hepatocyte Growth Factor/Scatter Factor-induced Signal Transduction through the Receptor Tyrosine Kinase c-Met

    R. Van Der Voort;T. E. I. Taher;V. J. M. Wielenga;M. Spaargaren

  • Powerful strategy for polymerase chain reaction-based clonality assessment in T-cell malignancies Report of the BIOMED-2 Concerted Action BHM4 CT98-3936.

    M. Brüggemann;H. White;P. Gaulard;R. Garcia-Sanz

  • Egress of CD19+CD5+ cells into peripheral blood following treatment with the Bruton tyrosine kinase inhibitor ibrutinib in mantle cell lymphoma patients

    Betty Y. Chang;Michelle Francesco;Martin F. M. De Rooij;Padmaja Magadala

  • Deletion of the WNT target and cancer stem cell marker CD44 in Apc(Min/+) mice attenuates intestinal tumorigenesis.

    Jurrit Zeilstra;Sander P.J. Joosten;Maarten Dokter;Eugène Verwiel

  • Lymphoma dissemination: the other face of lymphocyte homing

    Steven T. Pals;David J. J. de Gorter;Marcel Spaargaren

  • The hepatocyte growth factor/Met pathway controls proliferation and apoptosis in multiple myeloma.

    P W B Derksen;D J J de Gorter;H P Meijer;R J Bende

  • High prevalence of oncogenic MYD88 and CD79B mutations in diffuse large B-cell lymphomas presenting at immune-privileged sites.

    W Kraan;H M Horlings;M van Keimpema;E J M Schilder-Tol

  • RalGDS-like factor (Rlf) is a novel Ras and Rap 1A-associating protein

    R. M. F. Wolthuis;B. Bauer;L. J. Van't Veer;A. M. M. De Vries-Smits

  • Aberrant Wnt signaling in multiple myeloma: molecular mechanisms and targeting options

    Harmen van Andel;Kinga A. Kocemba;Marcel Spaargaren;Steven T. Pals

Frequent Co-Authors

Steven T. Pals
Steven T. Pals University of Amsterdam
Eric Eldering
Eric Eldering University of Amsterdam
Hans Clevers
Hans Clevers Hubrecht Institute for Developmental Biology and Stem Cell Research
Johannes Boonstra
Johannes Boonstra Utrecht University
Frederic Davi
Frederic Davi Assistance Publique – Hôpitaux de Paris
David Gonzalez
David Gonzalez University of California, San Diego
Paul J. Coffer
Paul J. Coffer Utrecht University
Roel Nusse
Roel Nusse Stanford University
Jan Paul Medema
Jan Paul Medema University of Amsterdam
Jin-Ping Li
Jin-Ping Li Uppsala University

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