What is he best known for?
The fields of study he is best known for:
Marcel Spaargaren spends much of his time researching Cancer research, Molecular biology, Gene rearrangement, Bruton's tyrosine kinase and Signal transduction.
His research on Cancer research frequently connects to adjacent areas such as Cell biology.
His work investigates the relationship between Molecular biology and topics such as Multiplex polymerase chain reaction that intersect with problems in Minimal residual disease, [email protected] and T-Cell Receptor Gene.
His work in Gene rearrangement addresses issues such as T-cell receptor, which are connected to fields such as Multiplex, Polymerase chain reaction and Heteroduplex.
The Bruton's tyrosine kinase study combines topics in areas such as Chronic lymphocytic leukemia, Ibrutinib, Cell adhesion, CXCL13 and B-cell receptor.
His Signal transduction study also includes
- Hepatocyte growth factor that connect with fields like Kinase and Paracrine signalling,
- Autocrine signalling which is related to area like Cell growth.
His most cited work include:
- Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. (2431 citations)
- The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia (375 citations)
- Differential Interaction of the Ras Family GTP-binding Proteins H-Ras, Rap1A, and R-Ras with the Putative Effector Molecules Raf Kinase and Ral-Guanine Nucleotide Exchange Factor* (294 citations)
What are the main themes of his work throughout his whole career to date?
His scientific interests lie mostly in Cancer research, Cell biology, Immunology, Signal transduction and Wnt signaling pathway.
He has included themes like Hepatocyte growth factor, Bruton's tyrosine kinase, Diffuse large B-cell lymphoma, B cell and Chronic lymphocytic leukemia in his Cancer research study.
His Cell biology study combines topics from a wide range of disciplines, such as Plasma cell, Bone marrow, Cell migration, Heparan sulfate and Biochemistry.
His Immunology research is multidisciplinary, relying on both Growth factor receptor, Gene rearrangement and Stem cell.
Marcel Spaargaren works mostly in the field of Signal transduction, limiting it down to topics relating to Cell growth and, in certain cases, Activator, as a part of the same area of interest.
His Wnt signaling pathway research incorporates elements of CD44 and Autocrine signalling.
He most often published in these fields:
- Cancer research (46.79%)
- Cell biology (38.53%)
- Immunology (19.27%)
What were the highlights of his more recent work (between 2013-2021)?
- Cancer research (46.79%)
- Wnt signaling pathway (13.76%)
- Cell biology (38.53%)
In recent papers he was focusing on the following fields of study:
Marcel Spaargaren mostly deals with Cancer research, Wnt signaling pathway, Cell biology, Immunology and Cell adhesion.
His studies deal with areas such as Protein kinase B, Stem cell, Lymphoma, PI3K/AKT/mTOR pathway and Chronic lymphocytic leukemia as well as Cancer research.
His Wnt signaling pathway study combines topics in areas such as Endocrinology, CD44, Autocrine signalling, Paracrine signalling and Internal medicine.
His study in Cell biology is interdisciplinary in nature, drawing from both Stromal cell and Bone marrow.
His work in Immunology addresses subjects such as Growth factor receptor, which are connected to disciplines such as Deubiquitinating Enzyme CYLD, Tumor suppressor gene and NFKB1.
The Cell adhesion study combines topics in areas such as Idelalisib, Homing and CXCR4.
Between 2013 and 2021, his most popular works were:
- Stem cell CD44v isoforms promote intestinal cancer formation in Apc(min) mice downstream of Wnt signaling (80 citations)
- Ibrutinib and idelalisib synergistically target BCR-controlled adhesion in MCL and CLL: a rationale for combination therapy (63 citations)
- FOXP1 directly represses transcription of proapoptotic genes and cooperates with NF-κB to promote survival of human B cells (62 citations)
In his most recent research, the most cited papers focused on:
His main research concerns Cancer research, Cell biology, Wnt signaling pathway, Paracrine signalling and Autocrine signalling.
He has researched Cancer research in several fields, including Immunology, Diffuse large B-cell lymphoma, NF-κB, Gene silencing and Transcription.
His work on Chronic lymphocytic leukemia as part of general Immunology research is frequently linked to Clinical success, bridging the gap between disciplines.
Marcel Spaargaren conducts interdisciplinary study in the fields of Cell biology and XBP1 through his works.
His research integrates issues of Cell signaling, CD44, Cancer stem cell, Adenomatous polyposis coli and Gene isoform in his study of Wnt signaling pathway.
His Paracrine signalling research includes themes of Syndecan 1, Beta-catenin, Wnt signalosome, Cytokine binding and Frizzled.
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