World's Best Scientists 2026 revealed!

D-Index & Metrics

Immunology

D-Index
117
Citations
48973
World Ranking
366
National Ranking
13

C. Erik Hack publication distribution in Immunology in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Immunology in 2026. The highlighted bar marks where C. Erik Hack sits on this spectrum.

62–71 publications: 9 scientists 72–81 publications: 23 scientists 82–91 publications: 40 scientists 92–101 publications: 72 scientists 102–111 publications: 86 scientists 112–121 publications: 108 scientists 122–131 publications: 150 scientists 132–141 publications: 160 scientists 142–151 publications: 159 scientists 152–161 publications: 189 scientists 162–171 publications: 166 scientists 172–181 publications: 181 scientists 182–191 publications: 188 scientists 192–201 publications: 187 scientists 202–211 publications: 178 scientists 212–221 publications: 158 scientists 222–231 publications: 168 scientists 232–241 publications: 159 scientists 242–251 publications: 160 scientists 252–261 publications: 148 scientists 262–271 publications: 116 scientists 272–281 publications: 125 scientists 282–291 publications: 115 scientists 292–301 publications: 111 scientists 302–311 publications: 95 scientists 312–321 publications: 97 scientists 322–331 publications: 97 scientists 332–341 publications: 99 scientists 342–351 publications: 96 scientists 352–361 publications: 68 scientists 362–371 publications: 76 scientists 372–381 publications: 71 scientists 382–391 publications: 71 scientists 392–401 publications: 62 scientists 402–411 publications: 54 scientists 412–421 publications: 41 scientists 422–431 publications: 63 scientists 432–441 publications: 53 scientists 442–451 publications: 31 scientists 452–461 publications: 42 scientists 462–471 publications: 40 scientists 472–481 publications: 29 scientists 482–491 publications: 34 scientists 492–501 publications: 30 scientists 502–511 publications: 23 scientists 512–521 publications: 41 scientists 522–531 publications: 29 scientists 532–541 publications: 28 scientists 542–551 publications: 16 scientists 552–561 publications: 18 scientists 562–571 publications: 18 scientists 572–581 publications: 17 scientists 582–591 publications: 17 scientists 592–601 publications: 17 scientists 602–611 publications: 19 scientists 612–621 publications: 13 scientists 622–631 publications: 12 scientists 632–641 publications: 11 scientists 642–651 publications: 16 scientists 652–661 publications: 9 scientists 662–671 publications: 5 scientists 672–681 publications: 13 scientists 682–691 publications: 12 scientists 692–701 publications: 6 scientists 702–711 publications: 6 scientists 712–721 publications: 9 scientists 722–731 publications: 9 scientists 732–741 publications: 6 scientists 742–751 publications: 11 scientists 752–761 publications: 10 scientists 762–771 publications: 7 scientists 772–781 publications: 12 scientists 782–791 publications: 7 scientists 792–801 publications: 5 scientists 802–806 publications: 1 scientists 807+ publications: 100 scientists
62 publications 807+

This scientist: 514 publications — 90th percentile

90% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 807 publications or more.

C. Erik Hack D-index placement in Immunology in 2026

The chart shows the D-index (discipline H-index) distribution of Immunology scientists ranked by Research.com in 2026. The highlighted bar marks where C. Erik Hack sits on this spectrum.

40–41 D-Index: 28 scientists 42–43 D-Index: 91 scientists 44–45 D-Index: 157 scientists 46–47 D-Index: 192 scientists 48–49 D-Index: 175 scientists 50–51 D-Index: 188 scientists 52–53 D-Index: 177 scientists 54–55 D-Index: 155 scientists 56–57 D-Index: 194 scientists 58–59 D-Index: 201 scientists 60–61 D-Index: 197 scientists 62–63 D-Index: 201 scientists 64–65 D-Index: 173 scientists 66–67 D-Index: 167 scientists 68–69 D-Index: 172 scientists 70–71 D-Index: 199 scientists 72–73 D-Index: 184 scientists 74–75 D-Index: 133 scientists 76–77 D-Index: 162 scientists 78–79 D-Index: 127 scientists 80–81 D-Index: 121 scientists 82–83 D-Index: 125 scientists 84–85 D-Index: 121 scientists 86–87 D-Index: 102 scientists 88–89 D-Index: 96 scientists 90–91 D-Index: 75 scientists 92–93 D-Index: 72 scientists 94–95 D-Index: 74 scientists 96–97 D-Index: 66 scientists 98–99 D-Index: 68 scientists 100–101 D-Index: 49 scientists 102–103 D-Index: 60 scientists 104–105 D-Index: 54 scientists 106–107 D-Index: 36 scientists 108–109 D-Index: 23 scientists 110–111 D-Index: 52 scientists 112–113 D-Index: 41 scientists 114–115 D-Index: 34 scientists 116–117 D-Index: 25 scientists 118–119 D-Index: 28 scientists 120–121 D-Index: 11 scientists 122–123 D-Index: 20 scientists 124–125 D-Index: 27 scientists 126–127 D-Index: 19 scientists 128–129 D-Index: 20 scientists 130–131 D-Index: 16 scientists 132–133 D-Index: 17 scientists 134–135 D-Index: 14 scientists 136–137 D-Index: 15 scientists 138–139 D-Index: 9 scientists 140–141 D-Index: 11 scientists 142–143 D-Index: 9 scientists 144–145 D-Index: 9 scientists 146–147 D-Index: 7 scientists 148–149 D-Index: 7 scientists 150–151 D-Index: 7 scientists 152–153 D-Index: 5 scientists 154–155 D-Index: 8 scientists 156 D-Index: 6 scientists 157+ D-Index: 96 scientists
40 D-Index 157+

This scientist: 117 D-Index — 93rd percentile

93% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 157 D-Index or more.

Overview

C. Erik Hack is affiliated with Utrecht University in the Netherlands. Their research spans multiple subfields within medicine, primarily focusing on immunology and related disciplines. The scientist's work covers areas such as immunology, hematology, neurology, genetics, and rheumatology, with significant contributions to the understanding of the complement system in diseases and monoclonal and polyclonal antibodies research.

The main topics of C. Erik Hack's research include:

  • Complement system in diseases
  • Coagulation, Bradykinin, Polyphosphates, and Angioedema
  • Monoclonal and Polyclonal Antibodies Research
  • Peripheral Neuropathies and Disorders
  • Urticaria and Related Conditions
  • Mast cells and histamine
  • Nanoparticle-Based Drug Delivery

Frequent coauthors collaborate with Hack on several studies, including:

  • Kim Dijkxhoorn
  • Inge Van de Walle
  • Kevin Budding
  • Elisabeth de Zeeuw
  • Jeanette H.W. Leusen

Hack has published in various highly regarded scientific journals, with multiple papers featured in the following venues:

  • Journal of Allergy and Clinical Immunology
  • Journal of Controlled Release
  • Clinical & Experimental Allergy
  • Journal of Chromatography A
  • Journal of Neuroinflammation

Notable recent publications include:

  • "Anti-PEG antibodies compromise the integrity of PEGylated lipid-based nanoparticles via complement," 2021, Journal of Controlled Release
  • "ARGX-117, a therapeutic complement inhibiting antibody targeting C2," 2020, Journal of Allergy and Clinical Immunology
  • "Evidence for bradykinin release in chronic spontaneous urticaria," 2020, Clinical & Experimental Allergy
  • "A generic sample preparation method for the multiplex analysis of seven therapeutic monoclonal antibodies in human plasma or serum with liquid chromatography-tandem mass spectrometry," 2021, Journal of Chromatography A
  • "Increased intra-articular granzyme M may trigger local IFN-λ1/IL-29 response in rheumatoid arthritis," 2020, Clinical and Experimental Rheumatology

The body of Hack's work delves into immune system mechanisms, particularly focusing on the role of complement proteins and antibodies in disease pathology. Studies also examine therapeutic approaches related to monoclonal antibodies and molecular analysis techniques. The research covers inflammatory and autoimmune conditions such as urticaria and rheumatoid arthritis, underlining the connection between cellular immune responses and clinical manifestations.

Best Publications

  • Increased plasma levels of interleukin-6 in sepsis.

    CE Hack;ER De Groot;RJ Felt-Bersma;JH Nuijens

  • Experimental endotoxemia in humans: analysis of cytokine release and coagulation, fibrinolytic, and complement pathways

    S. J. H. Van Deventer;H. R. Buller;J. W. Ten Cate;L. A. Aarden

  • Hereditary and acquired angioedema: problems and progress: proceedings of the third C1 esterase inhibitor deficiency workshop and beyond.

    Angelo Agostoni;Emel Aygören-Pürsün;Karen E. Binkley;Alvaro Blanch

  • Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin lymphomas

    Jessica L Teeling;Ruth R French;Mark S Cragg;Jeroen van den Brakel

  • Cell-derived microparticles circulate in healthy humans and support low grade thrombin generation.

    René J. Berckmans;Rienk Nieuwland;Anita N. Böing;Fred P. H. T. M. Romijn

  • Cellular origin and procoagulant properties of microparticles in meningococcal sepsis.

    R. Nieuwland;R. J. Berckmans;S. McGregor;A. N. Böing

  • Serum levels of interleukin-6 and acute phase responses.

    M.W.N. Nijsten;E.R. De Groot;H.J. Ten Duis;H.J. Klasen

  • C-Reactive Protein Colocalizes With Complement in Human Hearts During Acute Myocardial Infarction

    W.K. Lagrand;H.W.M. Niessen;G.J. Wolbink;L.H. Jaspars

  • Inhibition of endotoxin-induced activation of coagulation and fibrinolysis by pentoxifylline or by a monoclonal anti-tissue factor antibody in chimpanzees

    M Levi;H ten Cate;K A Bauer;T van der Poll

  • Elimination of interleukin 6 attenuates coagulation activation in experimental endotoxemia in chimpanzees.

    T van der Poll;M Levi;C E Hack;H ten Cate

  • Wegener's granulomatosis autoantibodies identify a novel diisopropylfluorophosphate-binding protein in the lysosomes of normal human neutrophils.

    R. Goldschmeding;C. E. Van Der Schoot;D. Ten Bokkel Huinink;C. E. Hack

  • Interleukin-8 in sepsis: relation to shock and inflammatory mediators.

    C E Hack;M Hart;R J van Schijndel;A J Eerenberg

  • Cell-Derived Microparticles Generated in Patients During Cardiopulmonary Bypass Are Highly Procoagulant

    Rienk Nieuwland;René J. Berckmans;Reni C. Rotteveel-Eijkman;Kyra N. Maquelin

  • Apoptosis in myocardial ischaemia and infarction

    P A J Krijnen;R Nijmeijer;C J L M Meijer;C A Visser

  • Role of Cytokines in Sepsis

    C.E. Hack;L.A. Aarden;L.G. Thijs

  • The endothelium in sepsis: source of and a target for inflammation.

    C. Hack;Sacha Zeerleder

  • Complement activation in amyloid plaques in Alzheimer's dementia

    P. Eikelenboom;C. E. Hack;J. M. Rozemuller;F. C. Stam

  • Interleukin-6 stimulates coagulation, not fibrinolysis, in humans.

    J. M. L. Stouthard;M. Levi;C. E. Hack;C. H. N. Veenhof

  • Human cell-derived microparticles promote thrombus formation in vivo in a tissue factor-dependent manner.

    E Biró;K N Sturk-Maquelin;G M T Vogel;D G Meuleman

  • Proinflammatory Effects of IL-10 During Human Endotoxemia

    F N Lauw;D Pajkrt;C E Hack;M Kurimoto

  • Disseminated intravascular coagulation in sepsis.

    Sacha Zeerleder;C. Erik Hack;Walter A. Wuillemin

  • Activation of protein C following infusion of protein C concentrate in children with severe meningococcal sepsis and purpura fulminans: A randomized, double-blinded, placebo-controlled, dose-finding study

    Ester D. de Kleijn;Ronald de Groot;C. Erik Hack;Paul G. H. Mulder

Frequent Co-Authors

Tom van der Poll
Tom van der Poll University of Amsterdam
Marcel Levi
Marcel Levi University of Amsterdam
S. Matthijs Boekholdt
S. Matthijs Boekholdt University of Amsterdam
Mohamed R. Daha
Mohamed R. Daha Leiden University
Taco W. Kuijpers
Taco W. Kuijpers University of Amsterdam
Nicholas J. Wareham
Nicholas J. Wareham University of Cambridge
Robert Luben
Robert Luben University College London
Lucien A. Aarden
Lucien A. Aarden University of Amsterdam
Rienk Nieuwland
Rienk Nieuwland University of Amsterdam
Kay-Tee Khaw
Kay-Tee Khaw University of Cambridge

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Related Online Degrees & Career Pathways

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