World's Best Scientists 2026 revealed!

D-Index & Metrics

Immunology

D-Index
117
Citations
48973
World Ranking
366
National Ranking
13

Overview

C. Erik Hack is affiliated with Utrecht University in the Netherlands. Their research spans multiple subfields within medicine, primarily focusing on immunology and related disciplines. The scientist's work covers areas such as immunology, hematology, neurology, genetics, and rheumatology, with significant contributions to the understanding of the complement system in diseases and monoclonal and polyclonal antibodies research.

The main topics of C. Erik Hack's research include:

  • Complement system in diseases
  • Coagulation, Bradykinin, Polyphosphates, and Angioedema
  • Monoclonal and Polyclonal Antibodies Research
  • Peripheral Neuropathies and Disorders
  • Urticaria and Related Conditions
  • Mast cells and histamine
  • Nanoparticle-Based Drug Delivery

Frequent coauthors collaborate with Hack on several studies, including:

  • Kim Dijkxhoorn
  • Inge Van de Walle
  • Kevin Budding
  • Elisabeth de Zeeuw
  • Jeanette H.W. Leusen

Hack has published in various highly regarded scientific journals, with multiple papers featured in the following venues:

  • Journal of Allergy and Clinical Immunology
  • Journal of Controlled Release
  • Clinical & Experimental Allergy
  • Journal of Chromatography A
  • Journal of Neuroinflammation

Notable recent publications include:

  • "Anti-PEG antibodies compromise the integrity of PEGylated lipid-based nanoparticles via complement," 2021, Journal of Controlled Release
  • "ARGX-117, a therapeutic complement inhibiting antibody targeting C2," 2020, Journal of Allergy and Clinical Immunology
  • "Evidence for bradykinin release in chronic spontaneous urticaria," 2020, Clinical & Experimental Allergy
  • "A generic sample preparation method for the multiplex analysis of seven therapeutic monoclonal antibodies in human plasma or serum with liquid chromatography-tandem mass spectrometry," 2021, Journal of Chromatography A
  • "Increased intra-articular granzyme M may trigger local IFN-λ1/IL-29 response in rheumatoid arthritis," 2020, Clinical and Experimental Rheumatology

The body of Hack's work delves into immune system mechanisms, particularly focusing on the role of complement proteins and antibodies in disease pathology. Studies also examine therapeutic approaches related to monoclonal antibodies and molecular analysis techniques. The research covers inflammatory and autoimmune conditions such as urticaria and rheumatoid arthritis, underlining the connection between cellular immune responses and clinical manifestations.

Best Publications

  • Increased plasma levels of interleukin-6 in sepsis.

    CE Hack;ER De Groot;RJ Felt-Bersma;JH Nuijens

  • Experimental endotoxemia in humans: analysis of cytokine release and coagulation, fibrinolytic, and complement pathways

    S. J. H. Van Deventer;H. R. Buller;J. W. Ten Cate;L. A. Aarden

  • Hereditary and acquired angioedema: problems and progress: proceedings of the third C1 esterase inhibitor deficiency workshop and beyond.

    Angelo Agostoni;Emel Aygören-Pürsün;Karen E. Binkley;Alvaro Blanch

  • Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin lymphomas

    Jessica L Teeling;Ruth R French;Mark S Cragg;Jeroen van den Brakel

  • Cell-derived microparticles circulate in healthy humans and support low grade thrombin generation.

    René J. Berckmans;Rienk Nieuwland;Anita N. Böing;Fred P. H. T. M. Romijn

  • Cellular origin and procoagulant properties of microparticles in meningococcal sepsis.

    R. Nieuwland;R. J. Berckmans;S. McGregor;A. N. Böing

  • Serum levels of interleukin-6 and acute phase responses.

    M.W.N. Nijsten;E.R. De Groot;H.J. Ten Duis;H.J. Klasen

  • C-Reactive Protein Colocalizes With Complement in Human Hearts During Acute Myocardial Infarction

    W.K. Lagrand;H.W.M. Niessen;G.J. Wolbink;L.H. Jaspars

  • Inhibition of endotoxin-induced activation of coagulation and fibrinolysis by pentoxifylline or by a monoclonal anti-tissue factor antibody in chimpanzees

    M Levi;H ten Cate;K A Bauer;T van der Poll

  • Elimination of interleukin 6 attenuates coagulation activation in experimental endotoxemia in chimpanzees.

    T van der Poll;M Levi;C E Hack;H ten Cate

  • Wegener's granulomatosis autoantibodies identify a novel diisopropylfluorophosphate-binding protein in the lysosomes of normal human neutrophils.

    R. Goldschmeding;C. E. Van Der Schoot;D. Ten Bokkel Huinink;C. E. Hack

  • Interleukin-8 in sepsis: relation to shock and inflammatory mediators.

    C E Hack;M Hart;R J van Schijndel;A J Eerenberg

  • Cell-Derived Microparticles Generated in Patients During Cardiopulmonary Bypass Are Highly Procoagulant

    Rienk Nieuwland;René J. Berckmans;Reni C. Rotteveel-Eijkman;Kyra N. Maquelin

  • Apoptosis in myocardial ischaemia and infarction

    P A J Krijnen;R Nijmeijer;C J L M Meijer;C A Visser

  • Role of Cytokines in Sepsis

    C.E. Hack;L.A. Aarden;L.G. Thijs

  • The endothelium in sepsis: source of and a target for inflammation.

    C. Hack;Sacha Zeerleder

  • Complement activation in amyloid plaques in Alzheimer's dementia

    P. Eikelenboom;C. E. Hack;J. M. Rozemuller;F. C. Stam

  • Interleukin-6 stimulates coagulation, not fibrinolysis, in humans.

    J. M. L. Stouthard;M. Levi;C. E. Hack;C. H. N. Veenhof

  • Human cell-derived microparticles promote thrombus formation in vivo in a tissue factor-dependent manner.

    E Biró;K N Sturk-Maquelin;G M T Vogel;D G Meuleman

  • Proinflammatory Effects of IL-10 During Human Endotoxemia

    F N Lauw;D Pajkrt;C E Hack;M Kurimoto

  • Disseminated intravascular coagulation in sepsis.

    Sacha Zeerleder;C. Erik Hack;Walter A. Wuillemin

  • Activation of protein C following infusion of protein C concentrate in children with severe meningococcal sepsis and purpura fulminans: A randomized, double-blinded, placebo-controlled, dose-finding study

    Ester D. de Kleijn;Ronald de Groot;C. Erik Hack;Paul G. H. Mulder

Frequent Co-Authors

Tom van der Poll
Tom van der Poll University of Amsterdam
Marcel Levi
Marcel Levi University of Amsterdam
S. Matthijs Boekholdt
S. Matthijs Boekholdt University of Amsterdam
Mohamed R. Daha
Mohamed R. Daha Leiden University
Taco W. Kuijpers
Taco W. Kuijpers University of Amsterdam
Nicholas J. Wareham
Nicholas J. Wareham University of Cambridge
Robert Luben
Robert Luben University College London
Lucien A. Aarden
Lucien A. Aarden University of Amsterdam
Rienk Nieuwland
Rienk Nieuwland University of Amsterdam
Kay-Tee Khaw
Kay-Tee Khaw University of Cambridge

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

For those interested in Immunology, pursuing related healthcare degrees can open diverse career opportunities. Many students leverage accelerated programs to enter the workforce faster. For example, an accelerated nurse practitioner program allows students to quickly gain advanced clinical skills and specialize in patient care, which is valuable for immunology-related healthcare roles.

Non-nurses aiming to transition into nursing can explore 12-month accelerated nursing programs online for non nurses. These programs provide a fast-track to nursing credentials, helping students build a strong foundation relevant to immunology and related medical fields.

For those seeking less competitive entry points, the easiest absn program to get into offers an opportunity to achieve a Bachelor of Science in Nursing without extensive barriers. This can be a stepping stone toward specialized immunology research or clinical roles.

Similarly, easy lpn programs to get into help students start careers as Licensed Practical Nurses, providing essential patient care experience that can complement further immunology study and practice.

Best Scientists Citing C. Erik Hack

Trending Scientists