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Immunology

D-Index
59
Citations
17573
World Ranking
3388
National Ranking
233

Overview

Axel Roers is a researcher affiliated with University Hospital Heidelberg in Germany. Their work primarily addresses questions in the fields of Immunology and Microbiology, as well as Medicine. Over their career, they have contributed extensively to topics related to immune cell behavior, inflammation, and molecular mechanisms underlying immune responses.

Their main fields of study include:

  • Immunology and Microbiology
  • Medicine

Within these broad domains, Roers has focused on specific subfields such as:

  • Immunology
  • Molecular Biology
  • Epidemiology
  • Immunology and Allergy
  • Oncology

Roers' research engages several main topics, highlighting particular areas of expertise and interest:

  • Immune cells in cancer
  • Mast cells and histamine
  • Immune Cell Function and Interaction
  • Interferon and immune responses
  • Cytomegalovirus and herpesvirus research
  • Immune Response and Inflammation
  • T-cell and B-cell Immunology

Contributions to scientific literature include publications in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Immunology
  • The Journal of Experimental Medicine
  • Journal of Investigative Dermatology
  • Nature Communications

Alex Roers has frequent collaboration relationships with other researchers, among them:

  • Alexander Gerbaulet
  • Rayk Behrendt
  • Andreas Dahl
  • Clara M. Munz
  • Sebastian Willenborg

Notable recent papers authored or co-authored by Axel Roers include:

  • Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing, 2021, Cell Metabolism
  • Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage, 2021, Immunity
  • A common framework of monocyte-derived macrophage activation, 2022, Science Immunology
  • The Generation of an Engineered Interleukin-10 Protein With Improved Stability and Biological Function, 2020, Frontiers in Immunology
  • Fate mapping of hematopoietic stem cells reveals two pathways of native thrombopoiesis, 2022, Nature Communications

Best Publications

  • Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

    Yuri P. Rubtsov;Jeffrey P. Rasmussen;Emil Y. Chi;Jason Fontenot

  • Clonal Expansions of Cd8+ T Cells Dominate the T Cell Infiltrate in Active Multiple Sclerosis Lesions as Shown by Micromanipulation and Single Cell Polymerase Chain Reaction

    Holger Babbe;Axel Roers;Ari Waisman;Hans Lassmann

  • Differential Roles of Macrophages in Diverse Phases of Skin Repair

    Tina Lucas;Ari Waisman;Rajeev Ranjan;Jürgen Roes

  • Mast cell and macrophage chemokines CXCL1/CXCL2 control the early stage of neutrophil recruitment during tissue inflammation.

    Katia De Filippo;Anne Dudeck;Mike Hasenberg;Emma Nye

  • Recognition of Endogenous Nucleic Acids by the Innate Immune System.

    Axel Roers;Björn Hiller;Veit Hornung;Veit Hornung;Veit Hornung

  • Multiple sclerosis: Brain-infiltrating CD8(+) T cells persist as clonal expansions in the cerebrospinal fluid and blood

    Christian Skulina;Stephan Schmidt;Klaus Dornmair;Holger Babbe

  • Mast cells are key promoters of contact allergy that mediate the adjuvant effects of haptens.

    Anne Dudeck;Jan Dudeck;Julia Scholten;Anke Petzold

  • Interrelation of immunity and tissue repair or regeneration.

    Sabine A. Eming;Matthias Hammerschmidt;Thomas Krieg;Axel Roers

  • A Single Strain of Clostridium butyricum Induces Intestinal IL-10-Producing Macrophages to Suppress Acute Experimental Colitis in Mice

    Atsushi Hayashi;Toshiro Sato;Nobuhiko Kamada;Yohei Mikami

  • T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation.

    Axel Roers;Lisa Siewe;Elke Strittmatter;Martina Deckert

  • Different activation signals induce distinct mast cell degranulation strategies

    Nicolas Gaudenzio;Riccardo Sibilano;Thomas Marichal;Philipp Starkl

  • Nonredundant Roles for B Cell-Derived IL-10 in Immune Counter-Regulation

    Rajat Madan;Filiz Demircik;Sangeetha Surianarayanan;Jessica L. Allen

  • Adenomatous Polyps Are Driven by Microbe-Instigated Focal Inflammation and Are Controlled by IL-10–Producing T Cells

    Kristen L. Dennis;Yunwei Wang;Nichole R. Blatner;Shuya Wang

  • Tolerance rather than immunity protects from Helicobacter pylori-induced gastric preneoplasia.

    Isabelle C. Arnold;Josephine Y. Lee;Manuel R. Amieva;Axel Roers

  • Rare Occurrence of Classical Hodgkin's Disease as a T Cell Lymphoma

    Markus Müschen;Klaus Rajewsky;Andreas Bräuninger;Audrey Sylvia Baur

  • TREX1 Deficiency Triggers Cell-Autonomous Immunity in a cGAS-Dependent Manner

    Andrea Ablasser;Inga Hemmerling;Jonathan L. Schmid-Burgk;Rayk Behrendt

  • IL-27 Promotes IL-10 Production by Effector Th1 CD4+ T Cells: A Critical Mechanism for Protection from Severe Immunopathology during Malaria Infection

    Ana Paula Freitas do Rosário;Tracey Lamb;Tracey Lamb;Philip Spence;Robin Stephens

  • Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing.

    Sebastian Willenborg;David E. Sanin;Alexander Jais;Xiaolei Ding

  • Accelerated wound closure in mice deficient for interleukin-10.

    Sabine A. Eming;Sabine Werner;Philippe Bugnon;Claudia Wickenhauser

  • Mast cell-specific Cre/loxP-mediated recombination in vivo

    Julia Scholten;Karin Hartmann;Alexander Gerbaulet;Thomas Krieg

  • Defective removal of ribonucleotides from DNA promotes systemic autoimmunity

    Claudia Günther;Barbara Kind;Martin A.M. Reijns;Nicole Berndt

Frequent Co-Authors

Werner Müller
Werner Müller University of Manchester
Karin Hartmann
Karin Hartmann University Hospital of Basel
Thomas Krieg
Thomas Krieg University of Cologne
Klaus Rajewsky
Klaus Rajewsky Max Delbrück Center for Molecular Medicine
David Voehringer
David Voehringer University of Erlangen-Nuremberg
Thilo Jakob
Thilo Jakob University of Giessen
Ralf Küppers
Ralf Küppers University of Duisburg-Essen
Ari Waisman
Ari Waisman Johannes Gutenberg University of Mainz
Stephen J. Galli
Stephen J. Galli Stanford University
Mindy Tsai
Mindy Tsai Stanford University

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