Sylvain Lesné

Overview

Best Publications

• A specific amyloid-|[beta]| protein assembly in the brain impairs memory

  Sylvain Lesné;Ming Teng Koh;Linda Kotilinek;Rakez Kayed

  3483
  Citations

• Amyloid oligomers: A joint experimental/computational perspective on Alzheimer's disease, Parkinson's disease, type II diabetes, and amyotrophic lateral sclerosis

  Phuong H. Nguyen;Ayyalusamy Ramamoorthy;Bikash R. Sahoo;Jie Zheng

  621
  Citations

• Accelerating Amyloid-β Fibrillization Reduces Oligomer Levels and Functional Deficits in Alzheimer Disease Mouse Models *

  Irene H. Cheng;Kimberly Scearce-Levie;Kimberly Scearce-Levie;Justin Legleiter;Justin Legleiter;Jorge J. Palop;Jorge J. Palop

  506
  Citations

• Brain amyloid-β oligomers in ageing and Alzheimer’s disease

  Sylvain E Lesne;Mathew A Sherman;Marianne Grant;Michael A Kuskowski

  501
  Citations

• Soluble Aβ oligomer production and toxicity

  Megan E. Larson;Sylvain E. Lesné

  462
  Citations

• The Complex PrPc-Fyn Couples Human Oligomeric Aβ with Pathological Tau Changes in Alzheimer's Disease

  Megan Larson;Mathew A. Sherman;Fatou Amar;Mario Ulisse Nuvolone;Mario Ulisse Nuvolone

  332
  Citations

• Ischemia-induced interleukin-6 as a potential endogenous neuroprotective cytokine against NMDA receptor-mediated excitoxicity in the brain

  Carine Ali;Olivier Nicole;Fabian Docagne;Sylvain Lesne

  307
  Citations

• Cyclooxygenase-2 inhibition improves amyloid-β-mediated suppression of memory and synaptic plasticity

  Linda A. Kotilinek;Marcus A. Westerman;Qinwen Wang;Qinwen Wang;Kimberly Panizzon

  292
  Citations

• NMDA Receptor Activation Inhibits α-Secretase and Promotes Neuronal Amyloid-β Production

  Sylvain Lesné;Carine Ali;Cecília Gabriel;Nicole Croci

  265
  Citations

• Plaque-bearing mice with reduced levels of oligomeric amyloid-β assemblies have intact memory function

  Sylvain Lesné;Linda Kotilinek;Karen H. Ashe

  222
  Citations

• Orally available compound prevents deficits in memory caused by the Alzheimer amyloid‐β oligomers

  Matthew Townsend;James P. Cleary;James P. Cleary;Tapan Mehta;Jacki Hofmeister

  206
  Citations

• Transforming Growth Factor-β1 Potentiates Amyloid-β Generation in Astrocytes and in Transgenic Mice

  Sylvain Lesné;Fabian Docagne;Cecı́lia Gabriel;Géraldine Liot

  170
  Citations

• Cognitive effects of cell-derived and synthetically-derived Aβ oligomers

  Miranda N. Reed;Jacki J. Hofmeister;Lisa Jungbauer;Alfred T. Welzel

  170
  Citations

• Soluble α-synuclein is a novel modulator of Alzheimer's disease pathophysiology.

  Megan E. Larson;Mathew A Sherman;Susan Greimel;Michael A Kuskowski

  150
  Citations

• Involvement of β-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity

  Huifang Ma;Sylvain Lesné;Linda Kotilinek;Jill V. Steidl-Nichols;Jill V. Steidl-Nichols

  146
  Citations

• β-Amyloid Modulation of Synaptic Transmission and Plasticity

  Deepa V. Venkitaramani;Jeannie Chin;William J. Netzer;Gunnar K. Gouras

  141
  Citations

• Transforming growth factor-beta and ischemic brain injury.

  Alain Buisson;Sylvain Lesne;Fabian Docagne;Carine Ali

  139
  Citations

• Angiopoietin-1-induced PI3-kinase activation prevents neuronal apoptosis

  S. Valable;A. Bellail;S. Lesné;G. Liot

  136
  Citations

• The amyloid-β oligomer Aβ*56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation.

  Fatou Amar;Mathew A. Sherman;Travis Rush;Megan Larson

  133
  Citations

• Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer’s disease

  Stephanie I. Alfonso;Julia A. Callender;Basavaraj Hooli;Corina E. Antal

  117
  Citations

• Smad3-dependent induction of plasminogen activator inhibitor-1 in astrocytes mediates neuroprotective activity of transforming growth factor-β1 against NMDA-induced necrosis

  Fabian Docagne;Olivier Nicole;Cecilia Gabriel;Mónica Fernández-Monreal

  104
  Citations