Shigeru Nakashima focuses on Cell biology, Biochemistry, Apoptosis, Molecular biology and Ceramide. His work carried out in the field of Cell biology brings together such families of science as Platelet, TGF alpha and A431 cells. His research in Phosphatidylinositol, Protein kinase C, Phospholipase D, Molecular cloning and Homology are components of Biochemistry.
His research in Phospholipase D intersects with topics in PLD2 and Isozyme. The study incorporates disciplines such as Microbiology, Peptide sequence, Fungal protein, Phospholipase C and Sequence analysis in addition to Molecular biology. He has included themes like Caspase, Cytochrome c and Sphingomyelin in his Ceramide study.
The scientist’s investigation covers issues in Biochemistry, Molecular biology, Phospholipase D, Cell biology and Protein kinase C. His Biochemistry research focuses on Platelet and how it connects with Biophysics. Shigeru Nakashima combines subjects such as Kinase, Protein kinase A and Complementary DNA, Peptide sequence, Gene with his study of Molecular biology.
His Phospholipase D course of study focuses on Tyrosine phosphorylation and Tyrosine-kinase inhibitor and Tyrosine kinase. His research integrates issues of Apoptosis, Ceramide and Cellular differentiation in his study of Cell biology. His Apoptosis study combines topics from a wide range of disciplines, such as Tumor necrosis factor alpha, Reactive oxygen species and Sphingomyelin.
His primary areas of investigation include Cell biology, Molecular biology, Apoptosis, Cancer research and Ceramide. His work deals with themes such as Sphingosine kinase, Internal medicine, Spindle apparatus and Endocrinology, which intersect with Cell biology. His Molecular biology research is multidisciplinary, relying on both Cell culture, Extracellular, Phospholipase D, Molecular cloning and Programmed cell death.
His Apoptosis study combines topics in areas such as Tumor necrosis factor alpha, Reactive oxygen species, Glutathione and Signal transduction. As a member of one scientific family, Shigeru Nakashima mostly works in the field of Ceramide, focusing on Sphingomyelin and, on occasion, Caspase. Shigeru Nakashima studies Biochemistry, namely Protein kinase C.
Shigeru Nakashima mainly focuses on Apoptosis, Programmed cell death, Cell biology, Cancer research and Biochemistry. His work in Apoptosis covers topics such as Sphingomyelin which are related to areas like Acid Ceramidase, Small interfering RNA and Gene product. His Programmed cell death study integrates concerns from other disciplines, such as Molecular biology, Superoxide, Tiron, Intracellular and Pharmacology.
In his research, Phospholipase D is intimately related to DNA fragmentation, which falls under the overarching field of Molecular biology. His studies deal with areas such as Epidermal growth factor and Epidermal growth factor receptor as well as Cell biology. His study in Biochemistry concentrates on Protein kinase C, Kinase, Reactive oxygen species and Pyrogallol.
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Characterization of Two Alternately Spliced Forms of Phospholipase D1 ACTIVATION OF THE PURIFIED ENZYMES BY PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE, ADP-RIBOSYLATION FACTOR, AND RHO FAMILY MONOMERIC GTP-BINDING PROTEINS AND PROTEIN KINASE C-α
Scott M. Hammond;John M. Jenco;Shigeru Nakashima;Karen Cadwallader.
Journal of Biological Chemistry (1997)
Cloning and Disruption of caPLB1, a Phospholipase B Gene Involved in the Pathogenicity of Candida albicans
Steven D. Leidich;Ashraf S. Ibrahim;Yue Fu;Anjni Koul.
Journal of Biological Chemistry (1998)
Protein kinase Cα (PKCα): Regulation and biological function
Journal of Biochemistry (2002)
Ceramide Formation Leads to Caspase-3 Activation during Hypoxic PC12 Cell Death INHIBITORY EFFECTS OF Bcl-2 ON CERAMIDE FORMATION AND CASPASE-3 ACTIVATION
Shin-ichi Yoshimura;Yoshiko Banno;Shigeru Nakashima;Katsunobu Takenaka.
Journal of Biological Chemistry (1998)
Comparison of mesenchymal stem cells from adipose tissue and bone marrow for ischemic stroke therapy
Yuka Ikegame;Kentaro Yamashita;Shin-Ichiro Hayashi;Hiroshi Mizuno.
TNF-α-Induced Sphingosine 1-Phosphate Inhibits Apoptosis Through a Phosphatidylinositol 3-Kinase/Akt Pathway in Human Hepatocytes
Yosuke Osawa;Yoshiko Banno;Masahito Nagaki;David A. Brenner.
Journal of Immunology (2001)
Ordering of ceramide formation, caspase activation, and Bax/Bcl-2 expression during etoposide-induced apoptosis in C6 glioma cells.
M Sawada;S Nakashima;Y Banno;H Yamakawa.
Cell Death & Differentiation (2000)
Epidermal growth factor plays a crucial role in mitogenic regulation of human brain tumor stem cells.
Akio Soeda;Akihito Inagaki;Naoki Oka;Yuka Ikegame.
Journal of Biological Chemistry (2008)
Inhibitory action of cyclic GMP on secretion, polyphosphoinositide hydrolysis and calcium mobilization in thrombin-stimulated human platelets.
Shigeru Nakashima;Toyohiko Tohmatsu;Hiroaki Hattori;Yukio Okano.
Biochemical and Biophysical Research Communications (1986)
Inhibition of neutral sphingomyelinase activation and ceramide formation by glutathione in hypoxic PC12 cell death.
Shin‐ichi Yoshimura;Yoshiko Banno;Shigeru Nakashima;Katsuhiko Hayashi.
Journal of Neurochemistry (2002)
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