Shigeru Nakashima

Overview

Best Publications

• Characterization of Two Alternately Spliced Forms of Phospholipase D1 ACTIVATION OF THE PURIFIED ENZYMES BY PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE, ADP-RIBOSYLATION FACTOR, AND RHO FAMILY MONOMERIC GTP-BINDING PROTEINS AND PROTEIN KINASE C-α

  Scott M. Hammond;John M. Jenco;Shigeru Nakashima;Karen Cadwallader

  778
  Citations

• Comparison of mesenchymal stem cells from adipose tissue and bone marrow for ischemic stroke therapy

  Yuka Ikegame;Kentaro Yamashita;Shin-Ichiro Hayashi;Hiroshi Mizuno

  366
  Citations

• Cloning and Disruption of caPLB1, a Phospholipase B Gene Involved in the Pathogenicity of Candida albicans

  Steven D. Leidich;Ashraf S. Ibrahim;Yue Fu;Anjni Koul

  361
  Citations

• Protein kinase Cα (PKCα): Regulation and biological function

  Shigeru Nakashima

  360
  Citations

• Ceramide Formation Leads to Caspase-3 Activation during Hypoxic PC12 Cell Death INHIBITORY EFFECTS OF Bcl-2 ON CERAMIDE FORMATION AND CASPASE-3 ACTIVATION

  Shin-ichi Yoshimura;Yoshiko Banno;Shigeru Nakashima;Katsunobu Takenaka

  308
  Citations

• TNF-α-Induced Sphingosine 1-Phosphate Inhibits Apoptosis Through a Phosphatidylinositol 3-Kinase/Akt Pathway in Human Hepatocytes

  Yosuke Osawa;Yoshiko Banno;Masahito Nagaki;David A. Brenner

  234
  Citations

• Ordering of ceramide formation, caspase activation, and Bax/Bcl-2 expression during etoposide-induced apoptosis in C6 glioma cells.

  M Sawada;S Nakashima;Y Banno;H Yamakawa

  232
  Citations

• Epidermal growth factor plays a crucial role in mitogenic regulation of human brain tumor stem cells.

  Akio Soeda;Akihito Inagaki;Naoki Oka;Yuka Ikegame

  226
  Citations

• Inhibitory action of cyclic GMP on secretion, polyphosphoinositide hydrolysis and calcium mobilization in thrombin-stimulated human platelets.

  Shigeru Nakashima;Toyohiko Tohmatsu;Hiroaki Hattori;Yukio Okano

  186
  Citations

• Inhibition of neutral sphingomyelinase activation and ceramide formation by glutathione in hypoxic PC12 cell death.

  Shin‐ichi Yoshimura;Yoshiko Banno;Shigeru Nakashima;Katsuhiko Hayashi

  175
  Citations

• Regulation of Membrane-bound Phospholipase D by Protein Kinase C in HL60 Cells SYNERGISTIC ACTION OF SMALL GTP-BINDING PROTEIN RhoA

  Kenji Ohguchi;Yoshiko Banno;Shigeru Nakashima;Yoshinori Nozawa

  167
  Citations

• Fasudil, a Rho kinase (ROCK) inhibitor, protects against ischemic neuronal damage in vitro and in vivo by acting directly on neurons

  Kentaro Yamashita;Yoshinori Kotani;Yoshinori Kotani;Yoshimi Nakajima;Masamitsu Shimazawa

  154
  Citations

• Cell permeable ROS scavengers, Tiron and Tempol, rescue PC12 cell death caused by pyrogallol or hypoxia/reoxygenation.

  Jun Yamada;Shinichi Yoshimura;Haruki Yamakawa;Motoshi Sawada

  153
  Citations

• MDM2 Enhances the Function of Estrogen Receptor α in Human Breast Cancer Cells

  Shigehira Saji;Naoki Okumura;Hidetaka Eguchi;Shigeru Nakashima

  142
  Citations

• Influence of Bax or Bcl-2 overexpression on the ceramide-dependent apoptotic pathway in glioma cells

  Motoshi Sawada;Shigeru Nakashima;Yoshiko Banno;Haruki Yamakawa

  137
  Citations

• Tumor Necrosis Factor Alpha-Induced Interleukin-8 Production via NF-κB and Phosphatidylinositol 3-Kinase/Akt Pathways Inhibits Cell Apoptosis in Human Hepatocytes

  Yosuke Osawa;Masahito Nagaki;Yoshiko Banno;David A. Brenner

  136
  Citations

• Activation of caspase-9 and -3 during H2O2-induced apoptosis of PC12 cells independent of ceramide formation.

  H Yamakawa;Y Ito;T Naganawa;Y Banno

  136
  Citations

• p53 regulates ceramide formation by neutral sphingomyelinase through reactive oxygen species in human glioma cells

  Motoshi Sawada;Shigeru Nakashima;Tohru Kiyono;Masanori Nakagawa

  135
  Citations

• p53-Independent ceramide formation in human glioma cells during gamma-radiation-induced apoptosis.

  S Hara;S Nakashima;T Kiyono;M Sawada

  122
  Citations

• The effects of pentobarbital, isoflurane, and propofol on immediate-early gene expression in the vital organs of the rat.

  Yoshihiro Hamaya;Tomoo Takeda;Shuji Dohi;Shigeru Nakashima

  116
  Citations