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Molecular Biology

D-Index
45
Citations
11044
World Ranking
2841
National Ranking
224

Overview

Michaela Frye is affiliated with the University of Cambridge in the United Kingdom. Their research primarily resides within the broad field of Biochemistry, Genetics, and Molecular Biology, with a particular focus on Molecular Biology.

Their work extensively covers topics related to RNA modifications and cancer, RNA research and splicing, and RNA and protein synthesis mechanisms. Additional research interests include cancer-related molecular mechanisms, cancer-related gene regulation, genomics and chromatin dynamics, and CRISPR and genetic engineering.

Frequent publication venues for Michaela Frye include bioRxiv (Cold Spring Harbor Laboratory), where they have published six papers. Other journals featuring their research include HemaSphere and Cancer Research with two publications each, alongside Nature and Nature Reviews Genetics.

Recent papers authored or co-authored by Michaela Frye are:

  • Mitochondrial RNA modifications shape metabolic plasticity in metastasis, 2022, Nature
  • RNA modifications in physiology and disease: towards clinical applications, 2023, Nature Reviews Genetics
  • Sequence- and structure-specific cytosine-5 mRNA methylation by NSUN6, 2020, Nucleic Acids Research
  • A Dynamic rRNA Ribomethylome Drives Stemness in Acute Myeloid Leukemia, 2022, Cancer Discovery
  • Noncanonical functions of the serine-arginine-rich splicing factor (SR) family of proteins in development and disease, 2021, BioEssays

Collaborations form a significant component of their research output. Frequent co-authors include Sylvain Delaunay, Susanne Bornelöv, Rebecca E. Wagner, Carsten Müller-Tidow, and Sabine Dietmann.

Best Publications

  • RNA modifications modulate gene expression during development

    Michaela Frye;Bryan T. Harada;Bryan T. Harada;Mikaela Behm;Chuan He;Chuan He

  • Aberrant methylation of tRNAs links cellular stress to neuro‐developmental disorders

    Sandra Blanco;Sabine Dietmann;Joana V Flores;Shobbir Hussain

  • Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis

    Kim B. Jensen;Charlotte A. Collins;Elisabete Nascimento;David W. Tan

  • RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis.

    Francesca Tuorto;Reinhard Liebers;Tanja Musch;Matthias Schaefer

  • NSun2-Mediated Cytosine-5 Methylation of Vault Noncoding RNA Determines Its Processing into Regulatory Small RNAs

    Shobbir Hussain;Abdulrahim A. Sajini;Sandra Blanco;Sabine Dietmann

  • Stem cell function and stress response are controlled by protein synthesis

    Sandra Blanco;Roberto Bandiera;Martyna Popis;Shobbir Hussain

  • RNA modifications regulating cell fate in cancer.

    Sylvain Delaunay;Michaela Frye

  • Stem cell depletion through epidermal deletion of Rac1.

    Salvador Aznar Benitah;Michaela Frye;Michaela Frye;Michael Glogauer;Michael Glogauer;Fiona M. Watt;Fiona M. Watt

  • The RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumors.

    Michaela Frye;Fiona M. Watt

  • Analysis of CLIP and iCLIP methods for nucleotide-resolution studies of protein-RNA interactions

    Yoichiro Sugimoto;Julian König;Shobbir Hussain;Blaž Zupan

  • RNA modifications: what have we learned and where are we headed?

    Michaela Frye;Samie R. Jaffrey;Tao Pan;Gideon Rechavi

  • Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment.

    Michaela Frye;Clare Gardner;Elizabeth R. Li;Isabel Arnold;Isabel Arnold

  • Mutation in NSUN2, which encodes an RNA methyltransferase, causes autosomal-recessive intellectual disability.

    Muzammil Ahmad Khan;Muzammil Ahmad Khan;Muhammad Arshad Rafiq;Abdul Noor;Shobbir Hussain

  • Whole exome sequencing identifies a splicing mutation in NSUN2 as a cause of a Dubowitz-like syndrome

    Fernando Jose Martinez;Jeong Ho Lee;Ji Eun Lee;Sandra Blanco

  • Deficient methylation and formylation of mt-tRNA Met wobble cytosine in a patient carrying mutations in NSUN3

    Lindsey Van Haute;Sabine Dietmann;Laura Kremer;Shobbir Hussain

  • Characterizing 5-methylcytosine in the mammalian epitranscriptome

    Shobbir Hussain;Jelena Aleksic;Sandra Blanco;Sabine Dietmann

  • MYC in mammalian epidermis: how can an oncogene stimulate differentiation?

    Fiona M. Watt;Michaela Frye;Salvador Aznar Benitah

  • The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate.

    Sandra Blanco;Agata Kurowski;Jennifer Nichols;Fiona M. Watt

  • Regulation of Human Epidermal Stem Cell Proliferation and Senescence Requires Polycomb- Dependent and -Independent Functions of Cbx4

    Nuno Miguel Luis;Lluis Morey;Stefania Mejetta;Gloria Pascual

  • Cytosine-5 RNA Methylation Regulates Neural Stem Cell Differentiation and Motility

    Joana V. Flores;Lucía Cordero-Espinoza;Lucía Cordero-Espinoza;Feride Oeztuerk-Winder;Amanda Andersson-Rolf

Frequent Co-Authors

Fiona M. Watt
Fiona M. Watt King's College London
Sabine Dietmann
Sabine Dietmann University of Cambridge
Salvador Aznar Benitah
Salvador Aznar Benitah Institució Catalana de Recerca i Estudis Avançats
Jernej Ule
Jernej Ule The Francis Crick Institute
Joseph G. Gleeson
Joseph G. Gleeson University of California, San Diego
Duncan T. Odom
Duncan T. Odom University of Cambridge
Sascha Sauer
Sascha Sauer Max Delbrück Center for Molecular Medicine
Eric A. Miska
Eric A. Miska University of Cambridge
Mark Helm
Mark Helm Johannes Gutenberg University of Mainz
Gideon Rechavi
Gideon Rechavi Sheba Medical Center

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