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D-Index & Metrics

Molecular Biology

D-Index
70
Citations
20865
World Ranking
1411
National Ranking
719

Overview

Michael J. Weber was affiliated with the University of Virginia in the United States. Their research primarily focused on medicine, with significant contributions in immunology and microbiology, as well as biochemistry, genetics, and molecular biology.

The scientist's work was concentrated in several subfields, including genetics, immunology, molecular biology, oncology, and pathology and forensic medicine. The main topics covered in their research involved chronic lymphocytic leukemia, phagocytosis and immune regulation, cell death mechanisms and regulation, immunodeficiency and autoimmune disorders, ubiquitin and proteasome pathways, colorectal cancer treatments and studies, and genetic factors in colorectal cancer.

Frequent coauthors collaborating with Michael J. Weber included:

  • Kallesh D. Jayappa
  • Vicki L. Gordon
  • Christopher G. Morris
  • Krista M. Isaac
  • Shekhar Saha

The scientist published articles in several venues, such as:

  • Blood Advances
  • Journal of Clinical Investigation
  • Blood
  • Cancer Research
  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature

Michael J. Weber was an author or coauthor of multiple research papers, including:

  • Extrinsic interactions in the microenvironment in vivo activate an antiapoptotic multidrug-resistant phenotype in CLL, 2021, Blood Advances
  • PP2A modulation overcomes multidrug resistance in chronic lymphocytic leukemia via mPTP-dependent apoptosis, 2023, Journal of Clinical Investigation
  • Modulation of the Tumor Suppressor Protein PP2A Using a Small Molecule Agonist Overcomes Multi-Drug Resistance through Mitochondrial Permeability Transition Pore (MPTP) Dependent Induction of Apoptosis in Chronic Lymphocytic Leukemia, 2020, Blood
  • Abstract 937: The PP2A activation using a small molecule agonist triggers apoptosis by releasing mitochondrial permeability transition pores in multi-drug resistant leukemic B cells, 2021, Cancer Research
  • Faculty Opinions recommendation of Adaptive mutability of colorectal cancers in response to targeted therapies., 2020, Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature

The body of work contributed to understanding mechanisms of multi-drug resistance, particularly in chronic lymphocytic leukemia, and included investigations into apoptosis induction and immune system regulation. This research intersected with clinical and molecular approaches to address challenges in cancer treatment and resistance.

Best Publications

  • Mitogen-activated protein kinases: specific messages from ubiquitous messengers

    Hans J. Schaeffer;Michael J. Weber

  • Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase

    Shonna A. Moodie;Berthe M. Willumsen;Michael J. Weber;Alan Wolfman

  • Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase).

    D. M. Payne;A. J. Rossomando;P. Martino;A. K. Erickson

  • ANTIAPOPTOTIC SIGNALLING BY THE INSULIN-LIKE GROWTH FACTOR I RECEPTOR, PHOSPHATIDYLINOSITOL 3-KINASE, AND AKT

    G Kulik;A Klippel;M J Weber

  • Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3',5'-monophosphate

    Jie Wu;Paul Dent;Tomas Jelinek;Alan Wolfman

  • Requirement for MAP kinase (ERK2) activity in interferon alpha- and interferon beta-stimulated gene expression through STAT proteins

    Michael David;Emanuel Petricoin;Christopher Benjamin;Richard Pine

  • MP1: A MEK Binding Partner That Enhances Enzymatic Activation of the MAP Kinase Cascade

    Hans J. Schaeffer;Andrew D. Catling;Scott T. Eblen;Lara S. Collier

  • Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinase.

    A J Rossomando;D M Payne;M J Weber;T W Sturgill

  • Androgen Receptor Phosphorylation REGULATION AND IDENTIFICATION OF THE PHOSPHORYLATION SITES

    Daniel Gioeli;Scott B. Ficarro;Jesse J. Kwiek;David Aaronson

  • Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective manner.

    Diem H.D. Nguyen;Andrew D. Catling;Donna J. Webb;Mauricio Sankovic

  • Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase.

    M L Samuels;M J Weber;J M Bishop;M McMahon

  • Role of a mitogen-activated protein kinase pathway in the induction of phase II detoxifying enzymes by chemicals.

    Rong Yu;Wei Lei;Sandhya Mandlekar;Michael J. Weber

  • Akt-Dependent and -Independent Survival Signaling Pathways Utilized by Insulin-Like Growth Factor I

    George Kulik;Michael J. Weber

  • PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation

    Jill K. Slack-Davis;Scott T. Eblen;Maja Zecevic;Scott A. Boerner

  • Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes.

    Scott T. Eblen;Jill K. Slack;Michael J. Weber;Andrew D. Catling

  • Reversal of Raf-1 activation by purified and membrane-associated protein phosphatases

    Paul Dent;Tomas Jelinek;Deborah K. Morrison;Michael J. Weber

  • Identification by mass spectrometry of threonine 97 in bovine myelin basic protein as a specific phosphorylation site for mitogen-activated protein kinase.

    A K Erickson;D M Payne;P A Martino;A J Rossomando

  • A proline-rich sequence unique to MEK1 and MEK2 is required for raf binding and regulates MEK function.

    A. D. Catling;H.-J. Schaeffer;C. W. M. Reuter;G. R. Reddy

  • Epinephrine Protects Cancer Cells from Apoptosis via Activation of cAMP-dependent Protein Kinase and BAD Phosphorylation

    Konduru S.R. Sastry;Yelena Karpova;Sergey Prokopovich;Adrienne J. Smith

  • Active MAP Kinase in Mitosis: Localization at Kinetochores and Association with the Motor Protein CENP-E

    Maja Zecevic;Andrew D. Catling;Scott T. Eblen;Luigina Renzi

Frequent Co-Authors

Thomas W. Sturgill
Thomas W. Sturgill University of Virginia
Mark R. Conaway
Mark R. Conaway University of Virginia
Jie Wu
Jie Wu Temple University
Emanuel F. Petricoin
Emanuel F. Petricoin George Mason University
Jordi Vila
Jordi Vila University of Barcelona
Craig L. Slingluff
Craig L. Slingluff University of Virginia
Jeffrey E. Gershenwald
Jeffrey E. Gershenwald The University of Texas MD Anderson Cancer Center
Donald F. Hunt
Donald F. Hunt University of Virginia
Dan Theodorescu
Dan Theodorescu University of Arizona
Michael O. Thorner
Michael O. Thorner University of Virginia

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