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Biology and Biochemistry

D-Index
58
Citations
9584
World Ranking
13419
National Ranking
5697

Overview

Lois E. Greene is affiliated with the National Institutes of Health in the United States with a research focus spanning biochemistry, genetics, molecular biology, medicine, and neuroscience. Their work is concentrated on molecular biology, neurology, cellular and molecular neuroscience, cell biology, and nutrition and dietetics. The scientist addresses several main research topics including Parkinson's Disease mechanisms and treatments, prion diseases and protein misfolding, cellular transport and secretion, nerve injury and regeneration, trace elements in health, cell adhesion molecules research, and hereditary neurological disorders.

Their publication record includes multiple papers in well-recognized journals, with notable recent works such as:

  • Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson's disease (2023, Cell Reports)
  • Inhibiting calpain 1 and 2 in cyclin G associated kinase-knockout mice mitigates podocyte injury (2020, JCI Insight)
  • Mutations in Parkinsonism-linked endocytic proteins synaptojanin1 and auxilin have synergistic effects on dopaminergic axonal pathology (2023, npj Parkinson's Disease)
  • Mechanisms for Curing Yeast Prions (2020, International Journal of Molecular Sciences)
  • The Properties and Domain Requirements for Phase Separation of the Sup35 Prion Protein In Vivo (2023, Biomolecules)

Greene frequently collaborates with several scholars, with frequent co-authors including Xiaohong Zhao, Daniel C. Masison, D. J. Vidyadhara, Mahalakshmi Somayaji, and Nigel Wade. These collaborative efforts contribute to their research productivity and reach across multiple disciplines.

The scientist's work is often published in venues such as Molecular and Cellular Biology, International Journal of Molecular Sciences, bioRxiv (Cold Spring Harbor Laboratory), Cell Reports, and JCI Insight. Molecular and Cellular Biology is one of the most frequent publication outlets for their research.

The scope of Greene's research covers biochemical and molecular mechanisms underlying neurodegenerative diseases, particularly Parkinson's disease, alongside investigations into prion biology and the cellular processes involving protein misfolding and phase separation. Their contributions extend to understanding cellular transport systems and neuroregenerative processes, as well as exploring the influence of trace elements in health.

Best Publications

  • Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease

    A. Beilina;I. N. Rudenko;A. Kaganovich;L. Civiero

  • Evidence for cross-bridge attachment in relaxed muscle at low ionic strength.

    B Brenner;M Schoenberg;J M Chalovich;L E Greene

  • Theoretical model for the cooperative equilibrium binding of myosin subfragment 1 to the actin-troponin-tropomyosin complex.

    Terrell L. Hill;Evan Eisenberg;Lois Greene

  • Cooperative binding of myosin subfragment-1 to the actin-troponin-tropomyosin complex

    Lois E. Greene;Evan Eisenberg

  • The Relation of Muscle Biochemistry to Muscle Physiology

    Evan Eisenberg;Lois E. Greene

  • A deleterious mutation in DNAJC6 encoding the neuronal-specific clathrin-uncoating co-chaperone auxilin, is associated with juvenile parkinsonism.

    Simon Edvardson;Yuval Cinnamon;Asaf Ta-Shma;Avraham Shaag

  • Multiple roles of auxilin and hsc70 in clathrin-mediated endocytosis.

    Evan Eisenberg;Lois E. Greene

  • Clathrin exchange during clathrin-mediated endocytosis

    Xufeng Wu;Xiaohong Zhao;Lauren Baylor;Shivani Kaushal

  • Lowe Syndrome Protein OCRL1 Interacts with Clathrin and Regulates Protein Trafficking between Endosomes and the Trans-Golgi Network

    Rawshan Choudhury;Aipo Diao;Fang Zhang;Evan Eisenberg

  • Role of cyclin G-associated kinase in uncoating clathrin-coated vesicles from non-neuronal cells.

    Tsvika Greener;Xiaohong Zhao;Hiroshi Nojima;Evan Eisenberg

  • Recruitment dynamics of GAK and auxilin to clathrin-coated pits during endocytosis

    Dong-won Lee;Xufeng Wu;Evan Eisenberg;Lois E. Greene

  • Endocytosis and clathrin-uncoating defects at synapses of auxilin knockout mice

    Yang-In Yim;Tao Sun;Ling-Gang Wu;Andrea Raimondi

  • Dissociation of clathrin from coated vesicles by the uncoating ATPase.

    L E Greene;E Eisenberg

  • Expression of auxilin or AP180 inhibits endocytosis by mislocalizing clathrin: evidence for formation of nascent pits containing AP1 or AP2 but not clathrin.

    X. Zhao;T. Greener;H. Al-Hasani;S.W. Cushman

  • Cooperative turning on of myosin subfragment 1 adenosinetriphosphatase activity by the troponin-tropomyosin-actin complex.

    David L. Williams;Lois E. Greene;Evan Eisenberg

  • Morphology and Dynamics of Clathrin/GGA1-coated Carriers Budding from the Trans-Golgi Network

    Rosa Puertollano;Nicole N. van der Wel;Lois E. Greene;Evan Eisenberg

  • Crosslinked myosin subfragment 1: a stable analogue of the subfragment-1.ATP complex

    Joseph M. Chalovich;Lois E. Greene;Evan Eisenberg

  • A yeast DNA J protein required for uncoating of clathrin-coated vesicles in vivo

    Babak Pishvaee;Giancarlo Costaguta;Bonny G. Yeung;Sergey Ryazantsev

  • Role for Hsp70 Chaperone in Saccharomyces cerevisiae Prion Seed Replication

    Youtao Song;Yue-xuan Wu;Giman Jung;Yusuf Tutar

  • The molecular chaperones Hsp90 and Hsc70 are both necessary and sufficient to activate hormone binding by glucocorticoid receptor.

    Thavamani Rajapandi;Lois E. Greene;Evan Eisenberg

Frequent Co-Authors

Evan Eisenberg
Evan Eisenberg National Institutes of Health
Alasdair C. Steven
Alasdair C. Steven National Institutes of Health
Juan S. Bonifacino
Juan S. Bonifacino National Institutes of Health
Rosa Puertollano
Rosa Puertollano National Institutes of Health
J. Paul Taylor
J. Paul Taylor St. Jude Children's Research Hospital
Alexis Brice
Alexis Brice Institut du Cerveau
Karen E. Morrison
Karen E. Morrison University of Southampton
Dena G. Hernandez
Dena G. Hernandez National Institutes of Health
Barth D. Grant
Barth D. Grant Rutgers, The State University of New Jersey

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