World's Best Scientists 2026 revealed!

D-Index & Metrics

Microbiology

D-Index
95
Citations
32175
World Ranking
538
National Ranking
250

Medicine

D-Index
95
Citations
32317
World Ranking
10089
National Ranking
5195

Overview

Irvin S. Y. Chen is affiliated with the University of California, Los Angeles in the United States. Their research spans multiple fields within the life sciences, including Biochemistry, Genetics and Molecular Biology, Immunology and Microbiology, and Medicine. The scientist's work has a particular focus on several interconnected subfields such as Molecular Biology, Immunology, Oncology, Genetics, and Virology.

Their research topics include:

  • CAR-T cell therapy research
  • CRISPR and Genetic Engineering
  • Immune Cell Function and Interaction
  • HIV Research and Treatment
  • RNA Interference and Gene Delivery
  • Virus-based gene therapy research
  • Cancer, Hypoxia, and Metabolism

Irvin S. Y. Chen has contributed to several recent scientific articles. Among these are:

  • "Lactate oxidase nanocapsules boost T cell immunity and efficacy of cancer immunotherapy," 2023, Science Translational Medicine
  • "Stem cell-derived CAR T cells traffic to HIV reservoirs in macaques," 2021, JCI Insight
  • "Robust CAR-T memory formation and function via hematopoietic stem cell delivery," 2021, PLoS Pathogens
  • "Enhanced Delivery of Rituximab Into Brain and Lymph Nodes Using Timed-Release Nanocapsules in Non-Human Primates," 2020, Frontiers in Immunology
  • "Cannabidiol modulates expression of type I IFN response genes and HIV infection in macrophages," 2022, Frontiers in Immunology

Frequent coauthors who have worked with Chen include:

  • Jing Wen
  • Gajendra W. Suryawanshi
  • Yunfeng Lu
  • Anjie Zhen
  • Scott G. Kitchen

The venues where Chen has frequently published are:

  • PLoS Pathogens (3 publications)
  • Frontiers in Immunology (3 publications)
  • Science Translational Medicine
  • Cement and Concrete Composites
  • JCI Insight

Best Publications

  • HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure.

    Jerome A. Zack;Salvatore J. Arrigo;Stacy R. Weitsman;Alan S. Go

  • Lentivirus-delivered stable gene silencing by RNAi in primary cells.

    Sheila A. Stewart;Derek M. Dykxhoorn;Deborah Palliser;Hana Mizuno

  • Comparison of Multi-Lineage Cells from Human Adipose Tissue and Bone Marrow

    Daniel A. De Ugarte;Kouki Morizono;Amir Elbarbary;Zeni Alfonso

  • Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5

    Xiao-Feng Qin;Dong Sung An;Irvin S. Y. Chen;David Baltimore

  • Dual infection of the central nervous system by AIDS viruses with distinct cellular tropisms.

    Yoshio Koyanagi;Steven Miles;Ronald T. Mitsuyasu;Jean E. Merrill

  • HIV-1 tropism for mononuclear phagocytes can be determined by regions of gp120 outside the CD4-binding domain.

    W. A. O'brien;Y. Koyanagi;Ali Namazie;Jia-Qi Zhao

  • The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycle

    J. B. M. Jowett;V. Planelles;B. Poon;N. P. Shah

  • Cytokines alter production of HIV-1 from primary mononuclear phagocytes

    Yoshio Koyanagi;William A. O'Brien;William A. O'Brien;Jia Qi Zhao;David W. Golde

  • High Rate of HTLV-II Infection in Seropositive IV Drug Abusers in New Orleans

    Helen Lee;Priscilla Swanson;Vernon S. Shorty;Jerome A. Zack

  • Incompletely reverse-transcribed human immunodeficiency virus type 1 genomes in quiescent cells can function as intermediates in the retroviral life cycle.

    J A Zack;A M Haislip;P Krogstad;I S Chen

  • High levels of unintegrated HIV-1 DNA in brain tissue of AIDS dementia patients

    Shen Pang;Yoshio Koyanagi;Steven Miles;Clayton Wiley

  • Human immunodeficiency virus type 1 Vpr induces apoptosis following cell cycle arrest.

    Sheila A. Stewart;Betty Poon;Jeremy B. M. Jowett;Irvin S. Y. Chen

  • HIV-1, macrophages, glial cells, and cytokines in AIDS nervous system disease.

    Jean E. Merrill;Irvin S. Y. Chen

  • Complete nucleotide sequence of an infectious clone of human T-cell leukemia virus type II: an open reading frame for the protease gene

    Kunitada Shimotohno;Yuri Takahashi;Nobuaki Shimizu;Takashi Gojobori

  • Interleukin-1 and tumor necrosis factor alpha can be induced from mononuclear phagocytes by human immunodeficiency virus type 1 binding to the CD4 receptor.

    J. E. Merrill;Y. Koyanagi;I. S. Y. Chen

  • Depressive Symptoms as Predictors of Medical Outcomes in HIV Infection

    Constantine G. Lyketsos;Donald R. Hoover;Marcella Guccione;Walton Senterfitt

  • The SCID-hu mouse as a model for HIV-1 infection

    Grace M. Aldrovandi;Gerold Feuer;Lianying Gao;Beth Jamieson

  • Induction of interleukin-1 and tumor necrosis factor alpha in brain cultures by human immunodeficiency virus type 1.

    J. E. Merrill;Y. Koyanagi;J. Zack;L. Thomas

  • Molecular characterization of genome of a novel human T-cell leukaemia virus.

    Irvin S. Y. Chen;Jami McLaughlin;Judith C. Gasson;Steven C. Clark

  • Identification of the putative transforming protein of the human T-cell leukemia viruses HTLV-I and HTLV-II

    Dennis J. Slamon;Kunitada Shimotohno;Martin J. Cline;David W. Golde

Frequent Co-Authors

Jerome A. Zack
Jerome A. Zack University of California, Los Angeles
Joseph D. Rosenblatt
Joseph D. Rosenblatt University of Miami
Yunfeng Lu
Yunfeng Lu University of California, Los Angeles
Otto O. Yang
Otto O. Yang University of California, Los Angeles
David W. Golde
David W. Golde University of California, Los Angeles
Robert E. Donahue
Robert E. Donahue National Institutes of Health
Yoshio Koyanagi
Yoshio Koyanagi Kyoto University
Neil P. Shah
Neil P. Shah University of California, San Francisco
Vicente Planelles
Vicente Planelles University of Utah
Kunitada Shimotohno
Kunitada Shimotohno National Center For Global Health and Medicine

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