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Hidetaka Kosako

Hidetaka Kosako

D-Index & Metrics

Molecular Biology

D-Index
47
Citations
11346
World Ranking
2723
National Ranking
203

Overview

Hidetaka Kosako is affiliated with the University of Tokushima in Japan. Their research spans multiple fields within biochemistry, genetics, molecular biology, and medicine, with a significant focus on molecular biology and immunology.

The scientist has contributed extensively to the study of ubiquitin and proteasome pathways, autophagy in disease and therapy, and RNA research and splicing. Additional topics explored include interferon and immune responses, endoplasmic reticulum stress and disease, cellular transport and secretion, and applications of click chemistry.

Recent publications demonstrate the breadth of their research interests:

  • "Binding of LAG-3 to stable peptide-MHC class II limits T cell function and suppresses autoimmunity and anti-cancer immunity" (2022, Immunity)
  • "AirID, a novel proximity biotinylation enzyme, for analysis of protein-protein interactions" (2020, eLife)
  • "Cell cycle-specific phase separation regulated by protein charge blockiness" (2022, Nature Cell Biology)
  • "A proximity biotinylation-based approach to identify protein-E3 ligase interactions induced by PROTACs and molecular glues" (2022, Nature Communications)
  • "A Wolbachia factor for male killing in lepidopteran insects" (2022, Nature Communications)

The scientist frequently publishes in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Cell Reports, iScience, and The Journal of Cell Biology.

Hidetaka Kosako collaborates regularly with several researchers, including:

  • Kohei Nishino
  • Tatsuya Sawasaki
  • Harunori Yoshikawa
  • Tatsuya Kaminishi
  • Takayuki Shima

Their primary areas of study are biochemistry, genetics, and molecular biology, supported by a substantial number of publications in medicine. Subfields with notable representation in their work include molecular biology, immunology, cell biology, epidemiology, and oncology.

Best Publications

  • Ubiquitin is phosphorylated by PINK1 to activate parkin

    Fumika Koyano;Kei Okatsu;Kei Okatsu;Hidetaka Kosako;Yasushi Tamura

  • Identification of a novel phosphorylation site on histone H3 coupled with mitotic chromosome condensation.

    Hidemasa Goto;Yasuko Tomono;Kozo Ajiro;Hidetaka Kosako

  • PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria.

    Kei Okatsu;Toshihiko Oka;Masahiro Iguchi;Kenji Imamura;Kenji Imamura

  • In vitro effects on microtubule dynamics of purified Xenopus M phase-activated MAP kinase.

    Yukiko Gotoh;Eisuke Nishida;Satoshi Matsuda;Nobuyuki Shiina

  • Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3.

    Hirohide Takebayashi;Shosei Yoshida;Michiya Sugimori;Hidetaka Kosako

  • Xenopus MAP kinase activator: identification and function as a key intermediate in the phosphorylation cascade.

    Matsuda S;Kosako H;Takenaka K;Moriyama K

  • Rho-kinase/ROCK is involved in cytokinesis through the phosphorylation of myosin light chain and not ezrin/radixin/moesin proteins at the cleavage furrow.

    Hidetaka Kosako;Toshimichi Yoshida;Fumio Matsumura;Toshimasa Ishizaki

  • Transcription factor expression and Notch-dependent regulation of neural progenitors in the adult rat spinal cord.

    Shin Ichi Yamamoto;Motoshi Nagao;Michiya Sugimori;Hidetaka Kosako

  • Phosphorylation of vimentin by Rho-associated kinase at a unique amino-terminal site that is specifically phosphorylated during cytokinesis.

    Hidemasa Goto;Hidetaka Kosako;Kazushi Tanabe;Maki Yanagida

  • Xenopus MAP kinase activator is a serine/threonine/tyrosine kinase activated by threonine phosphorylation.

    H Kosako;Y Gotoh;S Matsuda;M Ishikawa

  • Requirement for the MAP kinase kinase/MAP kinase cascade in Xenopus oocyte maturation.

    H. Kosako;Y. Gotoh;E. Nishida

  • Phosphorylated ubiquitin chain is the genuine Parkin receptor

    Kei Okatsu;Fumika Koyano;Mayumi Kimura;Hidetaka Kosako

  • cDNA cloning of MAP kinase kinase reveals kinase cascade pathways in yeasts to vertebrates.

    Hidetaka Kosako;Eisuke Nishida;Yukiko Gotoh

  • Parkin-catalyzed Ubiquitin-Ester Transfer Is Triggered by PINK1-dependent Phosphorylation

    Masahiro Iguchi;Yuki Kujuro;Yuki Kujuro;Kei Okatsu;Kei Okatsu;Fumika Koyano;Fumika Koyano

  • Phosphoproteomics reveals new ERK MAP kinase targets and links ERK to nucleoporin-mediated nuclear transport

    Hidetaka Kosako;Hidetaka Kosako;Nozomi Yamaguchi;Chizuru Aranami;Masato Ushiyama;Masato Ushiyama

  • Phosphorylation of Glial Fibrillary Acidic Protein at the Same Sites by Cleavage Furrow Kinase and Rho-associated Kinase *

    Hidetaka Kosako;Mutsuki Amano;Maki Yanagida;Kazushi Tanabe

  • Specific accumulation of Rho-associated kinase at the cleavage furrow during cytokinesis: Cleavage furrow-specific phosphorylation of intermediate filaments

    Hidetaka Kosako;Hidemasa Goto;Maki Yanagida;Kaori Matsuzawa

  • Activation of unliganded FGF receptor by extracellular phosphate potentiates proteolytic protection of FGF23 by its O-glycosylation

    Yuichi Takashi;Yuichi Takashi;Hidetaka Kosako;Shun Sawatsubashi;Yuka Kinoshita

  • PKA Regulates PINK1 Stability and Parkin Recruitment to Damaged Mitochondria through Phosphorylation of MIC60

    Shiori Akabane;Midori Uno;Naoki Tani;Shunta Shimazaki

  • Gene expression pattern Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3

    Hirohide Takebayashi;Shosei Yoshida;Michiya Sugimori;Hidetaka Kosako

Frequent Co-Authors

Seisuke Hattori
Seisuke Hattori Kitasato University
Yukiko Gotoh
Yukiko Gotoh University of Tokyo
Keiji Tanaka
Keiji Tanaka Tokyo Metropolitan Institute of Medical Science
Masaki Inagaki
Masaki Inagaki Mie University
Kozo Kaibuchi
Kozo Kaibuchi Nagoya University
Masato Nakafuku
Masato Nakafuku Cincinnati Children's Hospital Medical Center
Mutsuki Amano
Mutsuki Amano Nagoya University
Yukio Fujiki
Yukio Fujiki Kyushu University
Masatoshi Fujita
Masatoshi Fujita Kyushu University

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