World's Best Scientists 2026 revealed!

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Medicine

D-Index
90
Citations
26112
World Ranking
12332
National Ranking
136

Overview

Guo-Yuan Yang is affiliated with Shanghai Jiao Tong University in China. Their research is primarily focused on Neuroscience and Biochemistry, Genetics, and Molecular Biology, with significant contributions also in related subfields such as Neurology, Molecular Biology, Biomedical Engineering, Cancer Research, and Developmental Neuroscience.

The main topics explored in Yang's work include:

  • Neuroinflammation and Neurodegeneration Mechanisms
  • Extracellular vesicles in disease
  • MicroRNA in disease regulation
  • Barrier Structure and Function Studies
  • Neurological Disease Mechanisms and Treatments
  • Neurogenesis and neuroplasticity mechanisms
  • Immune cells in cancer

Yang has published numerous papers, with notable recent works including:

  • "M2 microglial small extracellular vesicles reduce glial scar formation via the miR-124/STAT3 pathway after ischemic stroke in mice," 2020, Theranostics
  • "M2 microglia-derived extracellular vesicles promote white matter repair and functional recovery via miR-23a-5p after cerebral ischemia in mice," 2022, Theranostics
  • "ACT001 attenuates microglia-mediated neuroinflammation after traumatic brain injury via inhibiting AKT/NFκB/NLRP3 pathway," 2022, Cell Communication and Signaling
  • "Blocking C3d+/GFAP+ A1 Astrocyte Conversion with Semaglutide Attenuates Blood-Brain Barrier Disruption in Mice after Ischemic Stroke," 2022, Aging and Disease
  • "Sleep Disorders in Stroke: An Update on Management," 2021, Aging and Disease

The frequent co-authors collaborating with Yang include:

  • Yaohui Tang
  • Zhijun Zhang
  • Shengju Wu
  • Yaying Song
  • Yongting Wang

Yang's research has been published in a number of scientific journals with multiple contributions to:

  • Aging and Disease
  • Stroke and Vascular Neurology
  • Journal of Cerebral Blood Flow & Metabolism
  • Stroke
  • Theranostics

The work undertaken by Yang covers a broad spectrum of neuroscience topics, with a strong emphasis on mechanisms of neuroinflammation, extracellular vesicle biology, and microRNA regulation. The application of these studies often revolves around neurological diseases such as ischemic stroke and traumatic brain injury, focusing on molecular pathways, cellular response, and potential therapeutic strategies.

Best Publications

  • Experimental intracerebral hemorrhage : relationship between brain edema, blood flow, and blood-brain barrier permeability in rats

    G. Y. Yang;A. L. Betz;T. L. Chenevert;James A Brunberg

  • The biphasic function of microglia in ischemic stroke.

    Yuanyuan Ma;Jixian Wang;Yongting Wang;Guo-Yuan Yang

  • Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia.

    G Yang;P H Chan;J Chen;E Carlson

  • Antithrombogenic property of bone marrow mesenchymal stem cells in nanofibrous vascular grafts.

    Craig K. Hashi;Yiqian Zhu;Guo-Yuan Yang;William L. Young

  • Reperfusion-induced injury to the blood-brain barrier after middle cerebral artery occlusion in rats.

    G Y Yang;A L Betz

  • M2 microglia-derived exosomes protect the mouse brain from ischemia-reperfusion injury via exosomal miR-124.

    Yaying Song;Zongwei Li;Tingting He;Meijie Qu

  • Reduced Ischemic Brain Injury in Interleukin-1β Converting Enzyme—Deficient Mice:

    Gerald P. Schielke;Gerald P. Schielke;Guo-Yuan Yang;Brenda D. Shivers;A. Lorris Betz

  • Transforming Growth Factor-β1 Increases Bad Phosphorylation and Protects Neurons Against Damage

    Yuan Zhu;Guo-Yuan Yang;Barbara Ahlemeyer;Li Pang

  • MicroRNA-9 Coordinates Proliferation and Migration of Human Embryonic Stem Cell-Derived Neural Progenitors

    Celine Delaloy;Lei Liu;Jin-A Lee;Hua Su

  • Vascular remodeling after ischemic stroke: mechanisms and therapeutic potentials.

    Jialing Liu;Yongting Wang;Yosuke Akamatsu;Chih Cheng Lee

  • Endothelial progenitor cell transplantation improves long-term stroke outcome in mice.

    Yongfeng Fan;Fanxia Shen;Fanxia Shen;Tim Frenzel;Wei Zhu

  • Attenuation of stroke size in rats using an adenoviral vector to induce overexpression of interleukin-1 receptor antagonist in brain.

    A. L. Betz;Guo-Yan Yang;B. L. Davidson

  • Diffusion-weighted magnetic resonance imaging of acute focal cerebral ischemia: comparison of signal intensity with changes in brain water and Na+,K(+)-ATPase activity.

    Jan Mintorovitch;G. Y. Yang;Hiroaki Shimizu;John Kucharczyk

  • Monocyte chemoattractant protein-1 expressed in neurons and astrocytes during focal ischemia in mice.

    Xiaoming Che;Wen Ye;Li Panga;Du Chu Wu

  • Interleukin-6 stimulates circulating blood-derived endothelial progenitor cell angiogenesis in vitro.

    Yongfeng Fan;Jianqin Ye;Fanxia Shen;Yiqian Zhu

  • Inhibition of TNFα attenuates infarct volume and ICAM-1 expression in ischemic mouse brain

    G.-Y. Yang;Chao Gong;Chao Gong;Zhen Qin;Wen Ye

  • MicroRNA-210 as a novel blood biomarker in acute cerebral ischemia.

    Lili Zeng;Jianrong Liu;Yongting Wang;Ling Wang

  • Cold-induced brain edema and infarction are reduced in transgenic mice overexpressing CuZn-superoxide dismutase.

    P. H. Chan;G. Y. Yang;S. F. Chen;E. Carlson

  • Overexpression of interleukin-1 receptor antagonist in the mouse brain reduces ischemic brain injury.

    Guo-Yuan Yang;Yong-Jie Zhao;Beverly L Davidson;A.Lorris Betz

  • CXCR4 Antagonist AMD3100 Protects Blood–Brain Barrier Integrity and Reduces Inflammatory Response After Focal Ischemia in Mice

    Jun Huang;Yaning Li;Yaohui Tang;Guanghui Tang

Frequent Co-Authors

William L. Young
William L. Young University of California, San Francisco
Michael T. Lawton
Michael T. Lawton Barrow Neurological Institute
Pak H. Chan
Pak H. Chan Stanford University
Kunlin Jin
Kunlin Jin University of North Texas Health Science Center
Nicholas M. Barbaro
Nicholas M. Barbaro The University of Texas at Austin
Philip Weinstein
Philip Weinstein University of Adelaide
Charles J. Epstein
Charles J. Epstein University of California, San Francisco
Thomas L. James
Thomas L. James University of California, San Francisco
Shanbao Tong
Shanbao Tong Shanghai Jiao Tong University
Qiang Li
Qiang Li Brookhaven National Laboratory

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