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Neuroscience

D-Index
87
Citations
25123
World Ranking
1263
National Ranking
641

Overview

Guohua Xi is affiliated with the University of Michigan-Ann Arbor in the United States and has a research focus primarily in medicine, with an emphasis on neurology and related subfields. Their work spans across epidemiology, cellular and molecular neuroscience, molecular biology, and immunology, reflecting a multidisciplinary approach to brain injury and neurological diseases.

The main topics explored in Xi's research include intracerebral and subarachnoid hemorrhage, acute ischemic stroke management, traumatic brain injury and neurovascular disturbances, cerebrospinal fluid and hydrocephalus, neurosurgical procedures and complications, neuroinflammation and neurodegeneration mechanisms, and intracranial aneurysms including treatment and complications.

Among recent published papers by Guohua Xi are:

  • Brain edema formation and therapy after intracerebral hemorrhage (2022, Neurobiology of Disease)
  • Novel targets, treatments, and advanced models for intracerebral haemorrhage (2022, EBioMedicine)
  • The Role of Thrombin in Brain Injury After Hemorrhagic and Ischemic Stroke (2020, Translational Stroke Research)
  • Mechanisms of neuroinflammation in hydrocephalus after intraventricular hemorrhage: a review (2022, Fluids and Barriers of the CNS)
  • Multinucleated Giant Cells in Experimental Intracerebral Hemorrhage (2020, Translational Stroke Research)

Xi frequently collaborates with several researchers. Prominent co-authors include:

  • Richard F. Keep
  • Ya Hua
  • Fenghui Ye
  • Sravanthi Koduri
  • Yingfeng Wan

The most common venues for Xi's publications are:

  • Translational Stroke Research with 13 publications
  • Fluids and Barriers of the CNS with 6 publications
  • Experimental Neurology with 5 publications
  • Stroke with 5 publications
  • CNS Neuroscience & Therapeutics with 4 publications

Guohua Xi's contributions center on understanding mechanisms underlying brain hemorrhage, stroke, and related neurovascular conditions, with a focus on neuroinflammation and injury response. This body of work intersects clinical management approaches and molecular neuroscience perspectives, spanning both experimental and translational research paradigms.

Best Publications

  • Mechanisms of brain injury after intracerebral haemorrhage

    Guohua Xi;Richard F Keep;Julian T Hoff

  • Intracerebral haemorrhage: mechanisms of injury and therapeutic targets

    Richard F Keep;Ya Hua;Guohua Xi

  • Brain edema after experimental intracerebral hemorrhage: role of hemoglobin degradation products

    Feng Ping Huang;Guohua Xi;Richard F. Keep;Ya Hua

  • Behavioral Tests After Intracerebral Hemorrhage in the Rat

    Ya Hua;Timothy J Schallert;Richard F. Keep;Jimin Wu

  • Iron and Iron-Handling Proteins in the Brain After Intracerebral Hemorrhage

    Jimin Wu;Ya Hua;Richard F. Keep;Takehiro Nakamura

  • The role of thrombin and thrombin receptors in ischemic, hemorrhagic and traumatic brain injury : deleterious or protective?

    Guohua Xi;Georg Reiser;Richard F. Keep

  • Role of Blood Clot Formation on Early Edema Development After Experimental Intracerebral Hemorrhage

    Guohua Xi;Kenneth R. Wagner;Kenneth R. Wagner;Richard F. Keep;Ya Hua

  • Erythrocytes and delayed brain edema formation following intracerebral hemorrhage in rats

    Guohua Xi;Richard F. Keep;Julian T. Hoff

  • Deferoxamine-induced attenuation of brain edema and neurological deficits in a rat model of intracerebral hemorrhage.

    Takehiro Nakamura;Richard F. Keep;Ya Hua;Timothy J Schallert

  • Brain injury after intracerebral hemorrhage: the role of thrombin and iron.

    Ya Hua;Richard F. Keep;Julian T. Hoff;Guohua Xi

  • Ultra-early clot aspiration after lysis with tissue plasminogen activator in a porcine model of intracerebral hemorrhage: edema reduction and blood-brain barrier protection.

    Kenneth R. Wagner;Guohua Xi;Ya Hua;Mario Zuccarello

  • Mechanisms of Edema Formation After Intracerebral Hemorrhage Effects of Extravasated Red Blood Cells on Blood Flow and Blood-Brain Barrier Integrity

    Guohua Xi;Ya Hua;R. Rick Bhasin;Steven R. Ennis

  • Attenuation of Thrombin-Induced Brain Edema by Cerebral Thrombin Preconditioning

    Guohua Xi;Richard F. Keep;Ya Hua;Jianming Xiang

  • Pathophysiology of brain edema formation.

    Guohua Xi;Richard F. Keep;Julian T. Hoff

  • Long-term effects of experimental intracerebral hemorrhage : the role of iron

    Ya Hua;Takehiro Nakamura;Richard F. Keep;Jimin Wu

  • Mechanisms of Hydrocephalus After Neonatal and Adult Intraventricular Hemorrhage

    Jennifer Strahle;Hugh J. L. Garton;Cormac O. Maher;Karin M. Muraszko

  • Injury mechanisms in acute intracerebral hemorrhage.

    D. Andrew Wilkinson;Aditya S. Pandey;B. Gregory Thompson;Richard F. Keep

  • Oxidative brain injury from extravasated erythrocytes after intracerebral hemorrhage

    Jimin Wu;Ya Hua;Richard F Keep;Timothy Schallert;Timothy Schallert

  • Deferoxamine mesylate in patients with intracerebral haemorrhage (i-DEF): a multicentre, randomised, placebo-controlled, double-blind phase 2 trial.

    Magdy Selim;Magdy Selim;Lydia D Foster;Claudia S Moy;Guohua Xi

  • Deferoxamine Reduces Intracerebral Hematoma-Induced Iron Accumulation and Neuronal Death in Piglets

    Yuxiang Gu;Ya Hua;Richard F. Keep;Lewis B. Morgenstern

  • Complement activation in the brain after experimental intracerebral hemorrhage

    Ya Hua;Guohua Xi;Richard F. Keep;Julian T. Hoff

Frequent Co-Authors

Timothy J Schallert
Timothy J Schallert The University of Texas at Austin
Scott K. Holland
Scott K. Holland Medpace (United States)
Guo Li Ming
Guo Li Ming University of Pennsylvania
Cesar V. Borlongan
Cesar V. Borlongan University of South Florida
Gang Chen
Gang Chen Guangxi Medical University
Hua Feng
Hua Feng Third Military Medical University
Sunghee Cho
Sunghee Cho Cornell University
Wayne M. Clark
Wayne M. Clark Oregon Health & Science University
Rajiv R. Ratan
Rajiv R. Ratan Cornell University

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