World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
78
Citations
34399
World Ranking
17818
National Ranking
8890

Overview

Edward B. Lee is affiliated with the University of Pennsylvania in the United States. Their research primarily focuses on medicine, with a specialized emphasis on neurology, physiology, molecular biology, psychiatry and mental health, as well as radiology, nuclear medicine, and imaging.

The scientist's work covers a range of topics including:

  • Alzheimer's disease research and treatments
  • Parkinson's Disease mechanisms and treatments
  • Dementia and cognitive impairment research
  • Amyotrophic lateral sclerosis research
  • Advanced neuroimaging techniques and applications
  • Neurological diseases and metabolism
  • Neuroinflammation and neurodegeneration mechanisms

Edward B. Lee has contributed extensively to the academic literature with notable recent papers such as:

  • Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation (2020, Nature Medicine)
  • SpaGCN: Integrating gene expression, spatial location and histology to identify spatial domains and spatially variable genes by graph convolutional network (2021, Nature Methods)
  • TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A (2022, Nature)
  • Distribution patterns of tau pathology in progressive supranuclear palsy (2020, Acta Neuropathologica)
  • APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease (2020, Acta Neuropathologica)

The frequent co-authors collaborating with Edward B. Lee include:

  • David J. Irwin
  • John Q. Trojanowski
  • David A. Wolk
  • Corey T. McMillan
  • Murray Grossman

The scientist's publications are commonly found in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Acta Neuropathologica
  • Alzheimer's & Dementia
  • Brain
  • Acta Neuropathologica Communications

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Stages of pTDP‐43 pathology in amyotrophic lateral sclerosis

    Johannes Brettschneider;Kelly Del Tredici;Jon B. Toledo;John L. Robinson

  • Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

    Erik C.B. Johnson;Eric B. Dammer;Duc M. Duong;Lingyan Ping

  • Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated

    John L Robinson;Edward B Lee;Sharon X Xie;Lior Rennert

  • Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

    Aude Nicolas;Kevin P. Kenna;Alan E. Renton;Alan E. Renton;Nicola Ticozzi

  • Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration

    Edward B. Lee;Virginia M.-Y. Lee;John Q. Trojanowski

  • Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies

    Manuela Neumann;Manuela Neumann;Linda K. Kwong;Edward B. Lee;Elisabeth Kremmer

  • Neuropathological and Genetic Correlates of Survival and Dementia Onset in Synucleinopathies: A Retrospective Analysis

    David J Irwin;Murray Grossman;Daniel Weintraub;Daniel Weintraub;Howard I Hurtig

  • SpaGCN: Integrating gene expression, spatial location and histology to identify spatial domains and spatially variable genes by graph convolutional network.

    Jian Hu;Xiangjie Li;Kyle Coleman;Amelia Schroeder

  • Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy

    Gabor G. Kovacs;Isidro Ferrer;Lea T. Grinberg;Lea T. Grinberg;Irina Alafuzoff

  • Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model

    Bin Zhang;Arpita Maiti;Sharon Shively;Fara Lakhani

  • Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice

    Lionel M. Igaz;Linda K. Kwong;Edward B. Lee;Alice Chen-Plotkin

  • Targeting Amyloid-β Peptide (Aβ) Oligomers by Passive Immunization with a Conformation-selective Monoclonal Antibody Improves Learning and Memory in Aβ Precursor Protein (APP) Transgenic Mice

    Edward B. Lee;Lewis Z. Leng;Bin Zhang;Linda Kwong

  • Distribution patterns of tau pathology in progressive supranuclear palsy

    Gabor G. Kovacs;Gabor G. Kovacs;Gabor G. Kovacs;Milica Jecmenica Lukic;Milica Jecmenica Lukic;David J. Irwin;Thomas Arzberger

  • Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias

    Mark Yarchoan;Sharon X. Xie;Mitchel A. Kling;Mitchel A. Kling;Jon B. Toledo

  • C9orf72 BAC Transgenic Mice Display Typical Pathologic Features of ALS/FTD.

    Jacqueline G O'Rourke;Laurent P Bogdanik;A K M G Muhammad;Tania F Gendron

  • TDP-43 pathology and neuronal loss in amyotrophic lateral sclerosis spinal cord

    Johannes Brettschneider;Kimihito Arai;Kelly Del Tredici;Jon B. Toledo

  • Frontotemporal lobar degeneration: defining phenotypic diversity through personalized medicine

    David J. Irwin;Nigel J. Cairns;Murray Grossman;Corey T. McMillan

  • Axonal Transport, Amyloid Precursor Protein, Kinesin-1, and the Processing Apparatus: Revisited

    Orly Lazarov;Gerardo A. Morfini;Edward B. Lee;Mohamed H. Farah

  • Genome-Wide Analyses Identify KIF5A as a Novel ALS Gene

    Aude Nicolas;Kevin P. Kenna;Alan E. Renton;Nicola Ticozzi

Frequent Co-Authors

John Q. Trojanowski
John Q. Trojanowski University of Pennsylvania
David J. Irwin
David J. Irwin University of Pennsylvania
Murray Grossman
Murray Grossman University of Pennsylvania
Virginia M.-Y. Lee
Virginia M.-Y. Lee University of Pennsylvania
Vivianna M. Van Deerlin
Vivianna M. Van Deerlin University of Pennsylvania
Corey T. McMillan
Corey T. McMillan University of Pennsylvania
David A. Wolk
David A. Wolk University of Pennsylvania
Sharon X. Xie
Sharon X. Xie University of Pennsylvania
Gabor G. Kovacs
Gabor G. Kovacs University of Toronto
Jon B. Toledo
Jon B. Toledo Houston Methodist

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

For those interested in medicine but seeking flexible study options, online degrees can open doors to a range of healthcare careers. Accredited online programs are now available for many fields, making it easier to balance education with work or family commitments.

If you want to enter the healthcare sector quickly, look into the cheapest medical coding certification online. This certification is an excellent path for roles in medical billing and health information management.

Aspiring nurses have multiple options. There are comprehensive nursing degree online pathways suitable for both new students and practicing professionals looking to advance. For advanced practice roles, you can explore the cheapest nurse practitioner programs which lead to higher autonomy and earnings.

If academic research or leadership in nursing interests you, online PhD programs in nursing can prepare you for those advanced roles. Online routes often provide affordability and flexibility but require strong motivation and time management skills.

Best Scientists Citing Edward B. Lee

Trending Scientists

Recently Published Articles