Brian M. Baker

Best Publications

• Four A6-TCR/peptide/HLA-A2 structures that generate very different T cell signals are nearly identical.

  Yuan-Hua Ding;Brian M Baker;David N Garboczi;William E Biddison

  466
  Citations

• Genomic and bioinformatic profiling of mutational neoepitopes reveals new rules to predict anticancer immunogenicity

  Fei Duan;Jorge Duitama;Sahar Al Seesi;Cory M. Ayres

  436
  Citations

• T cell receptor cross-reactivity directed by antigen-dependent tuning of peptide-MHC molecular flexibility.

  Oleg Y. Borbulevych;Kurt H. Piepenbrink;Brian E. Gloor;Daniel R. Scott

  257
  Citations

• The structure and stability of an HLA-A*0201/octameric tax peptide complex with an empty conserved peptide-N-terminal binding site

  Amir R. Khan;Brian M. Baker;Partho Ghosh;William E. Biddison

  208
  Citations

• Development of a PD-L1 Complementary Diagnostic Immunohistochemistry Assay (SP142) for Atezolizumab

  Bharathi Vennapusa;Brian Baker;Marcin Kowanetz;Jennifer Boone

  186
  Citations

• Conversion of a T Cell Antagonist into an Agonist by Repairing a Defect in the TCR/Peptide/MHC Interface: Implications for TCR Signaling

  Brian M. Baker;Susan J. Gagnon;William E. Biddison;Don C. Wiley;Don C. Wiley

  177
  Citations

• TCRs Used in Cancer Gene Therapy Cross-React with MART-1/Melan-A Tumor Antigens via Distinct Mechanisms.

  Unknown

  171
  Citations

• Prediction of neo-epitope immunogenicity reveals TCR recognition determinants and provides insight into immunoediting.

  Julien Schmidt;Angela R. Smith;Morgane Magnin;Julien Racle;Julien Racle

  168
  Citations

• Conformational changes and flexibility in T-cell receptor recognition of peptide-MHC complexes.

  Unknown

  164
  Citations

• Poor immunogenicity of a self/tumor antigen derives from peptide–MHC-I instability and is independent of tolerance

  Zhiya Yu;Marc R. Theoret;Christopher E. Touloukian;Deborah R. Surman

  159
  Citations

• Increased Immunogenicity of an Anchor-Modified Tumor-Associated Antigen Is Due to the Enhanced Stability of the Peptide/MHC Complex: Implications for Vaccine Design

  Oleg Y. Borbulevych;Tiffany K. Baxter;Zhiya Yu;Nicholas P. Restifo

  147
  Citations

• Two different T cell receptors use different thermodynamic strategies to recognize the same peptide/MHC ligand.

  Unknown

  137
  Citations

• Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity

  Jarrett J Adams;Jarrett J Adams;Samanthi Narayanan;Michael E Birnbaum;Sachdev S Sidhu

  135
  Citations

• T cell receptor therapeutics: immunological targeting of the intracellular cancer proteome

  Unknown

  124
  Citations

• Identification of a Crucial Energetic Footprint on the α1 Helix of Human Histocompatibility Leukocyte Antigen (Hla)-A2 That Provides Functional Interactions for Recognition by Tax Peptide/Hla-A2–Specific T Cell Receptors

  Brian M. Baker;Richard V. Turner;Susan J. Gagnon;Don C. Wiley;Don C. Wiley

  119
  Citations

• Structures of MART-126/27-35 Peptide/HLA-A2 complexes reveal a remarkable disconnect between antigen structural homology and T cell recognition.

  Oleg Y. Borbulevych;Francis K. Insaidoo;Tiffany K. Baxter;Daniel J. Powell

  112
  Citations

• Poor immunogenicity of a self/tumor antigen derives from peptide–MHC-I instability and is independent of tolerance

  Unknown

  111
  Citations

• Structural and dynamic control of T-cell receptor specificity, cross-reactivity, and binding mechanism

  Unknown

  104
  Citations

• Cutting Edge: Evidence for a Dynamically Driven T Cell Signaling Mechanism

  William F. Hawse;Matthew M. Champion;Michelle V. Joyce;Lance M. Hellman

  101
  Citations

• T cell receptor cross-reactivity expanded by dramatic peptide-MHC adaptability.

  Timothy P Riley;Lance M Hellman;Marvin H Gee;Juan L Mendoza

  100
  Citations