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Molecular Biology

D-Index
112
Citations
54447
World Ranking
338
National Ranking
200

Overview

Tom Misteli is affiliated with the National Institutes of Health in the United States. Their research primarily falls within the broad field of Biochemistry, Genetics and Molecular Biology, with a particular concentration in Molecular Biology. Additional areas of study include Biophysics, Plant Science, Cancer Research, and Immunology.

Their work covers several main topics related to genetic and cellular processes. Key topics include:

  • RNA Research and Splicing
  • Genomics and Chromatin Dynamics
  • Nuclear Structure and Function
  • RNA and Protein Synthesis Mechanisms
  • Cell Image Analysis Techniques
  • Single-cell and Spatial Transcriptomics
  • Chromosomal and Genetic Variations

The researcher has published extensively, with notable recent papers including:

  • The Self-Organizing Genome: Principles of Genome Architecture and Function, 2020, Cell
  • Computational methods for analysing multiscale 3D genome organization, 2023, Nature Reviews Genetics
  • Systematic screening identifies therapeutic antisense oligonucleotides for Hutchinson-Gilford progeria syndrome, 2021, Nature Medicine
  • Self-assembly of multi-component mitochondrial nucleoids via phase separation, 2021, The EMBO Journal
  • Mesoscale structure-function relationships in mitochondrial transcriptional condensates, 2022, Proceedings of the National Academy of Sciences

Misteli frequently collaborates with other researchers. Coauthors with the highest collaborative counts include Gianluca Pegoraro, Adib Keikhosravi, Elizabeth H. Finn, Varun Sood, and Marina Feric.

Publishing venues prominently featuring Misteli's work include bioRxiv (Cold Spring Harbor Laboratory), Cell, Nature Reviews Genetics, Nature Medicine, and Nature Genetics.

Best Publications

  • Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

    Paola Scaffidi;Tom Misteli;Marco E. Bianchi

  • RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

    Poulikos I. Poulikakos;Yogindra Persaud;Manickam Janakiraman;Xiangju Kong

  • High mobility of proteins in the mammalian cell nucleus

    Robert D. Phair;Tom Misteli

  • Beyond the sequence : Cellular organization of genome function

    Tom Misteli

  • Lamin A-Dependent Nuclear Defects in Human Aging

    Paola Scaffidi;Tom Misteli

  • Regulation of Alternative Splicing by Histone Modifications

    Reini F. Luco;Qun Pan;Kaoru Tominaga;Benjamin J. Blencowe

  • Hyperdynamic Plasticity of Chromatin Proteins in Pluripotent Embryonic Stem Cells

    Eran Meshorer;Dhananjay Yellajoshula;Eric George;Peter J. Scambler

  • Epigenetics in alternative pre-mRNA splicing.

    Reini F. Luco;Mariano Alló;Ignacio Esteban Schor;Alberto Rodolfo Kornblihtt

  • Ubiquitination regulates PTEN nuclear import and tumor suppression

    Lloyd C. Trotman;Xinjiang Wang;Andrea Alimonti;Zhenbang Chen

  • Chromatin in pluripotent embryonic stem cells and differentiation

    Eran Meshorer;Tom Misteli

  • Protein dynamics: implications for nuclear architecture and gene expression.

    Tom Misteli

  • Global Transcription in Pluripotent Embryonic Stem Cells

    Sol Efroni;Radharani Duttagupta;Jill Cheng;Hesam Dehghani

  • The dynamics of a pre-mRNA splicing factor in living cells.

    Tom Misteli;Javier F. Cáceres;David L. Spector

  • The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis

    Anup Dey;Farideh Chitsaz;Asim Abbasi;Tom Misteli

  • Dynamic binding of histone H1 to chromatin in living cells

    Tom Misteli;Akash Gunjan;Robert Hock;Michael Bustin

  • Maintenance of stable heterochromatin domains by dynamic HP1 binding.

    Thierry Cheutin;Adrian J. McNairn;Thomas Jenuwein;David M. Gilbert

  • Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome

    Paola Scaffidi;Tom Misteli

  • The emerging role of nuclear architecture in DNA repair and genome maintenance

    Tom Misteli;Evi Soutoglou

  • The concept of self-organization in cellular architecture

    Tom Misteli

  • Applications of the green fluorescent protein in cell biology and biotechnology

    Tom Misteli;David L. Spector

Frequent Co-Authors

Miroslav Dundr
Miroslav Dundr Rosalind Franklin University of Medicine and Science
David L. Spector
David L. Spector Cold Spring Harbor Laboratory
Stephen J. Lockett
Stephen J. Lockett National Institutes of Health
Michael Bustin
Michael Bustin National Institutes of Health
Gordon L. Hager
Gordon L. Hager National Institutes of Health
Christophe Nicot
Christophe Nicot University of Kansas
Job Dekker
Job Dekker University of Massachusetts Chan Medical School
Tatiana S. Karpova
Tatiana S. Karpova National Institutes of Health
Jason D. Lieb
Jason D. Lieb University of Chicago

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