World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
68
Citations
15971
World Ranking
7819
National Ranking
3556

Research.com Recognitions

  • 1955 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

James G. McNally is a researcher affiliated with the National Institutes of Health in the United States. They have contributed to studies spanning multiple disciplines, primarily within Biochemistry, Genetics and Molecular Biology, as well as Physics and Astronomy.

Their work focuses notably on areas such as Advanced X-ray Imaging Techniques, Advanced Electron Microscopy Techniques and Applications, RNA Interference and Gene Delivery, Lysosomal Storage Disorders Research, Adenosine and Purinergic Signaling, Digital Holography and Microscopy, and Lipid Membrane Structure and Behavior.

McNally has published research in multiple venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • ACS Nano
  • Chemistry and Physics of Lipids
  • Proceedings of the National Academy of Sciences
  • Frontiers in Cell and Developmental Biology

Their recent papers reflect a focus on cellular structures, imaging, and molecular transport processes:

  • Cells Undergo Major Changes in the Quantity of Cytoplasmic Organelles after Uptake of Gold Nanoparticles with Biologically Relevant Surface Coatings (2020, ACS Nano)
  • Niemann Pick C2 protein enables cholesterol transfer from endo-lysosomes to the plasma membrane for efflux by shedding of extracellular vesicles (2021, Chemistry and Physics of Lipids)
  • 3D surface reconstruction of cellular cryo-soft X-ray microscopy tomograms using semisupervised deep learning (2023, Proceedings of the National Academy of Sciences)
  • 3D-surface reconstruction of cellular cryo-soft X-ray microscopy tomograms using semi-supervised deep learning (2022, bioRxiv (Cold Spring Harbor Laboratory))
  • Kinetic modelling of sterol transport between plasma membrane and endo-lysosomes based on quantitative fluorescence and X-ray imaging data (2023, Frontiers in Cell and Developmental Biology)

Frequent collaborators in McNally's research include Gerd Schneider, Stephan Werner, Helge Ewers, Burcu Kepsutlu, and Peter Guttmann.

McNally's publications document significant engagement with methodologies involving imaging and analysis at the cellular and molecular level. Their research intersects with both experimental approaches and computational modeling techniques.

Their work spans subfields such as Molecular Biology, Physiology, Radiation, Structural Biology, and Atomic and Molecular Physics, and Optics.

Among recognitions received is the title of Fellow of the American Association for the Advancement of Science (AAAS), awarded in 1955.

Best Publications

  • The Glucocorticoid Receptor: Rapid Exchange with Regulatory Sites in Living Cells

    James G. McNally;Waltraud G. Müller;Dawn Walker;Ronald Wolford

  • Analysis of Binding Reactions by Fluorescence Recovery after Photobleaching

    Brian L. Sprague;Robert L. Pego;Diana A. Stavreva;James G. McNally

  • FRAP analysis of binding: proper and fitting

    Brian L. Sprague;James G. McNally

  • Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks

    Michael J. Kruhlak;Arkady Celeste;Graham Dellaire;Oscar Fernandez-Capetillo

  • Three-dimensional imaging by deconvolution microscopy.

    James G. McNally;Tatiana Karpova;John Cooper;José Angel Conchello

  • E-cadherin-mediated adhesion inhibits ligand-dependent activation of diverse receptor tyrosine kinases.

    Xiaolan Qian;Tatiana Karpova;Allan M Sheppard;James McNally

  • Fluorescence resonance energy transfer from cyan to yellow fluorescent protein detected by acceptor photobleaching using confocal microscopy and a single laser

    T. S. Karpova;C. T. Baumann;L. He;X. Wu

  • Three-dimensional cellular ultrastructure resolved by X-ray microscopy

    Gerd Schneider;Peter Guttmann;Stefan Heim;Stefan Rehbein

  • Brd4 Marks Select Genes on Mitotic Chromatin and Directs Postmitotic Transcription

    Anup Dey;Akira Nishiyama;Tatiana Karpova;James McNally

  • SUMO-1 targets RanGAP1 to kinetochores and mitotic spindles

    Jomon Joseph;Shyh-Han Tan;Tatiana S. Karpova;James G. McNally

  • A benchmark for chromatin binding measurements in live cells.

    Davide Mazza;Alice Abernathy;Nicole Golob;Tatsuya Morisaki

  • Rapid Glucocorticoid Receptor Exchange at a Promoter Is Coupled to Transcription and Regulated by Chaperones and Proteasomes

    Diana A. Stavreva;Waltraud G. Müller;Gordon L. Hager;Carolyn L. Smith

  • Regulation of RNA polymerase II activation by histone acetylation in single living cells

    Timothy J. Stasevich;Yoko Hayashi-Takanaka;Yuko Sato;Kazumitsu Maehara

  • Genome-wide protein–DNA binding dynamics suggest a molecular clutch for transcription factor function

    Colin R. Lickwar;Florian Mueller;Florian Mueller;Sean E. Hanlon;Sean E. Hanlon;James G. McNally

  • Dynamic behavior of transcription factors on a natural promoter in living cells.

    Matthias Becker;Christopher Baumann;Sam John;Dawn A. Walker

  • Large-scale chromatin decondensation and recondensation regulated by transcription from a natural promoter.

    Waltraud G. Müller;Dawn Walker;Gordon L. Hager;James G. McNally

  • Crm1 is a mitotic effector of Ran-GTP in somatic cells.

    Alexei Arnaoutov;Yoshiaki Azuma;Katharina Ribbeck;Jomon Joseph;Jomon Joseph

  • FRAP and kinetic modeling in the analysis of nuclear protein dynamics: what do we really know?

    Florian Mueller;Davide Mazza;Timothy J Stasevich;James G McNally

  • Capping Protein Levels Influence Actin Assembly and Cell Motility in Dictyostelium

    Christopher Hug;Patrick Y. Jay;Indira Reddy;James G. McNally

  • Evidence for a common mode of transcription factor interaction with chromatin as revealed by improved quantitative fluorescence recovery after photobleaching.

    Florian Mueller;Florian Mueller;Paul Wach;James G. McNally

Frequent Co-Authors

Tatiana S. Karpova
Tatiana S. Karpova National Institutes of Health
Gordon L. Hager
Gordon L. Hager National Institutes of Health
Zlatko Trajanoski
Zlatko Trajanoski Innsbruck Medical University
Charles Vinson
Charles Vinson National Institutes of Health
Richard A. Firtel
Richard A. Firtel University of California, San Diego
John A. Cooper
John A. Cooper Washington University in St. Louis
Pierre A. Henkart
Pierre A. Henkart National Institutes of Health
Mary Dasso
Mary Dasso National Institutes of Health
Keiko Ozato
Keiko Ozato Eunice Kennedy Shriver National Institute of Child Health and Human Development
Anita B. Roberts
Anita B. Roberts National Institutes of Health

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing James G. McNally

Trending Scientists

Recently Published Articles