Royston Jefferis

Overview

Best Publications

• Post-translational modifications in the context of therapeutic proteins

  GR Walsh;Royston Jefferis

  1231
  Citations

• Glycosylation of Recombinant Antibody Therapeutics

  Royston Jefferis

  828
  Citations

• Structural Analysis of Human Igg-Fc Glycoforms Reveals a Correlation between Glycosylation and Structural Integrity

  S. Krapp;Y. Mimura;R. Jefferis;Robert Huber

  789
  Citations

• Multiple interactions of IgG with its core oligosaccharide can modulate recognition by complement and human Fc gamma receptor I and influence the synthesis of its oligosaccharide chains.

  J Lund;N Takahashi;J D Pound;M Goodall

  545
  Citations

• Recombinant antibody therapeutics: the impact of glycosylation on mechanisms of action

  Royston Jefferis

  454
  Citations

• Human Fc gamma RI and Fc gamma RII interact with distinct but overlapping sites on human IgG.

  J Lund;G Winter;P T Jones;J D Pound

  435
  Citations

• Evaluation of Monoclonal-antibodies Having Specificity for Human-igg Sub-classes - Results of An Iuis Who Collaborative Study

  R. Jefferis;C.B. Reimer;F. Skvaril;G.G. de Lange

  419
  Citations

• The influence of glycosylation on the thermal stability and effector function expression of human IgG1-Fc: properties of a series of truncated glycoforms.

  Y Mimura;S Church;R Ghirlando;P.R Ashton

  415
  Citations

• Selective IgG subclass deficiency: quantification and clinical relevance

  R. Jefferis;D. S. Kumararatne

  356
  Citations

• Isotype and glycoform selection for antibody therapeutics

  Royston Jefferis

  323
  Citations

• Oligosaccharide-protein interactions in IgG can modulate recognition by Fc gamma receptors.

  John Lund;Noriko Takahashi;John D. Pound;Margaret Goodall

  314
  Citations

• Mapping and comparison of the interaction sites on the Fc region of IgG responsible for triggering antibody dependent cellular cytotoxicity (ADCC) through different types of human Fcγ receptor

  Gabriella Sarmay;John Lund;Zoltan Rozsnyay;Janos Gergely

  306
  Citations

• Aglycosylation of human IgG1 and IgG3 monoclonal antibodies can eliminate recognition by human cells expressing Fc gamma RI and/or Fc gamma RII receptors.

  M R Walker;J Lund;K M Thompson;R Jefferis

  288
  Citations

• Use of antibody-coated red cells for the sensitive detection of antigen and in rosette tests for cells bearing surface immunoglobulins.

  N.R. Ling;S. Bishop;R. jefferis

  272
  Citations

• A comparative study of the N-linked oligosaccharide structures of human IgG subclass proteins.

  R Jefferis;J Lund;H Mizutani;H Nakagawa

  258
  Citations

• Structure of human IgM rheumatoid factor Fab bound to its autoantigen IgG Fc reveals a novel topology of antibody-antigen interaction.

  Adam L. Corper;Maninder K. Sohi;Vincent R. Bonagura;Michael Steinitz

  253
  Citations

• Localisation of the monocyte-binding region on human immunoglobulin G.

  J.M. Woof;L.J. Partridge;R. Jefferis;D.R. Burton

  251
  Citations

• A protein structural change in aglycosylated IgG3 correlates with loss of huFcγR1 and hufcγR111 binding and/or activation

  Lund J;Tanaka T;Takahashi N;Sarmay G

  225
  Citations

• Recognition sites on human IgG for Fcγ receptors: the role of glycosylation

  Royston Jefferis;John Lund;Margaret Goodall

  225
  Citations

• Differential glycosylation of polyclonal IgG, IgG-Fc and IgG-Fab isolated from the sera of patients with ANCA-associated systemic vasculitis

  M. Holland;H. Yagi;N. Takahashi;K. Kato

  224
  Citations