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Molecular Biology

D-Index
59
Citations
35627
World Ranking
1993
National Ranking
993

Overview

Richard I. Gregory is affiliated with Boston Children's Hospital in the United States. Their research primarily focuses on Biochemistry, Genetics, and Molecular Biology, with a specialization in Molecular Biology. Their work bridges Cancer Research, Clinical Biochemistry, Surgery, and even Electrical and Electronic Engineering.

Their main research topics include:

  • RNA modifications and cancer
  • Cancer-related gene regulation
  • Cancer-related molecular mechanisms research
  • RNA Research and Splicing
  • RNA and protein synthesis mechanisms
  • RNA regulation and disease
  • HVDC Systems and Fault Protection

Recent papers authored or coauthored by Richard I. Gregory cover a range of topics within molecular biology and RNA regulation. These include:

  • METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation, 2021, Molecular Cell
  • tRNA dysregulation and disease, 2022, Nature Reviews Genetics
  • The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function, 2020, The Journal of Experimental Medicine
  • Genetic drivers of m6A methylation in human brain, lung, heart and muscle, 2021, Nature Genetics
  • Exon junction complex shapes the m6A epitranscriptome, 2022, Nature Communications

Frequent coauthors in their publications include:

  • Esteban A. Orellana
  • Erdem Sendinc
  • Qi Liu
  • Mehdi Pirouz
  • Raja Hussain Ali

Their research has been published frequently in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Nucleic Acids Research
  • Molecular Cell
  • Nature

Best Publications

  • The Microprocessor complex mediates the genesis of microRNAs

    Richard I. Gregory;Kai Ping Yan;Govindasamy Amuthan;Thimmalah Chendrimada

  • Many roads to maturity: microRNA biogenesis pathways and their regulation

    Julia Winter;Stephanie Jung;Sarina Keller;Richard I. Gregory

  • TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing.

    Thimmaiah P. Chendrimada;Richard I. Gregory;Easwari Kumaraswamy;Easwari Kumaraswamy;Jessica Norman

  • MicroRNA biogenesis pathways in cancer

    Shuibin Lin;Richard I. Gregory

  • Human RISC Couples MicroRNA Biogenesis and Posttranscriptional Gene Silencing

    Richard I. Gregory;Thimmaiah P. Chendrimada;Neil Cooch;Ramin Shiekhattar

  • Selective blockade of microRNA processing by Lin28.

    Srinivas R. Viswanathan;George Q. Daley;George Q. Daley;Richard I. Gregory

  • The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells.

    Shuibin Lin;Shuibin Lin;Junho Choe;Junho Choe;Peng Du;Peng Du;Robinson Triboulet;Robinson Triboulet

  • The imprinted H19 lncRNA antagonizes let-7 microRNAs.

    Amanda N. Kallen;Xiao-Bo Zhou;Xiao-Bo Zhou;Jie Xu;Chong Qiao;Chong Qiao

  • The Lin28/let-7 axis regulates glucose metabolism

    Hao Zhu;Ng Shyh-Chang;Ayellet V. Segrè;Ayellet V. Segrè;Gen Shinoda

  • EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent

    Kexin Xu;Zhenhua Jeremy Wu;Anna C. Groner;Housheng Hansen He

  • MicroRNA biogenesis and cancer

    Richard I. Gregory;Ramin Shiekhattar

  • MicroRNA silencing through RISC recruitment of eIF6

    Thimmaiah P. Chendrimada;Kenneth J. Finn;Xinjun Ji;David Baillat

  • Lin28A and Lin28B Inhibit let-7 MicroRNA Biogenesis by Distinct Mechanisms

    Elena Piskounova;Christos Polytarchou;James E. Thornton;James E. Thornton;Robert J. LaPierre;Robert J. LaPierre

  • mRNA circularization by METTL3–eIF3h enhances translation and promotes oncogenesis

    Junho Choe;Shuibin Lin;Shuibin Lin;Shuibin Lin;Wencai Zhang;Qi Liu;Qi Liu

  • Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells

    John P Hagan;Elena Piskounova;Richard I Gregory

  • How does Lin28 let-7 control development and disease?

    James E. Thornton;Richard I. Gregory;Richard I. Gregory

  • Molecular Basis for Interaction of let-7 MicroRNAs with Lin28.

    Yunsun Nam;Casandra Chen;Casandra Chen;Richard I. Gregory;Richard I. Gregory;James J. Chou

  • Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28.

    Elena Piskounova;Srinivas R. Viswanathan;Maja Janas;Robert J. LaPierre

  • Podocyte-Specific Loss of Functional MicroRNAs Leads to Rapid Glomerular and Tubular Injury

    Jacqueline Ho;Kar Hui Ng;Seymour Rosen;Ales Dostal

  • Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia.

    Jasmin Paris;Jasmin Paris;Marcos Morgan;Joana Monteiro De Campos;Joana Monteiro De Campos;Gary J. Spencer

Frequent Co-Authors

George Q. Daley
George Q. Daley Boston Children's Hospital
David A. Williams
David A. Williams Boston Children's Hospital
Daniel E. Bauer
Daniel E. Bauer Harvard University
robert feil
robert feil Centre national de la recherche scientifique, CNRS
Stuart H. Orkin
Stuart H. Orkin Harvard University
Ramin Shiekhattar
Ramin Shiekhattar University of Miami
Konrad Hochedlinger
Konrad Hochedlinger Harvard University
Yang Shi
Yang Shi University of Oxford
Alexander Meissner
Alexander Meissner Max Planck Institute for Molecular Genetics
David Altshuler
David Altshuler Harvard University

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