World's Best Scientists 2026 revealed!
Miguel Ramalho-Santos

Miguel Ramalho-Santos

D-Index & Metrics

Molecular Biology

D-Index
41
Citations
13101
World Ranking
3043
National Ranking
91

Overview

Miguel Ramalho-Santos is affiliated with the University of Toronto in Canada and has a research focus spanning multiple areas within biochemistry, genetics, and molecular biology. Their body of work encompasses significant contributions to molecular biology, plant science, oncology, genetics, and pediatrics, perinatology and child health.

The scientist's work addresses topics including CRISPR and genetic engineering, chromosomal and genetic variations, genomics and chromatin dynamics, epigenetics and DNA methylation, RNA modifications and cancer, pluripotent stem cells research, and RNA research and splicing.

Frequent coauthors of Miguel Ramalho-Santos include Évelyne Collignon, Brandon Cho, Giacomo Furlan, Kirti Mittal, and Yun-Kyo Kim.

Their research has appeared extensively in several journals, with a notable presence in bioRxiv (Cold Spring Harbor Laboratory) where seven publications are recorded. Other recurring publication venues include Cell Reports, Nature Cell Biology, Nature Communications, and Cell.

Key recent papers authored by Miguel Ramalho-Santos include:

  • "Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy" (2021) published in Cell
  • "Homotypic clustering of L1 and B1/Alu repeats compartmentalizes the 3D genome" (2021) published in Cell Research
  • "Genomic Repeats Categorize Genes with Distinct Functions for Orchestrated Regulation" (2020) published in Cell Reports
  • "Regulation, functions and transmission of bivalent chromatin during mammalian development" (2022) published in Nature Reviews Molecular Cell Biology
  • "What Doesn't Kill You Makes You Stronger: Transposons as Dual Players in Chromatin Regulation and Genomic Variation" (2020) published in BioEssays

Best Publications

  • "Stemness": Transcriptional Profiling of Embryonic and Adult Stem Cells

    Miguel Ramalho-Santos;Soonsang Yoon;Yumi Matsuzaki;Richard C. Mulligan

  • Hedgehog signals regulate multiple aspects of gastrointestinal development.

    Miguel Ramalho-Santos;Douglas A. Melton;Andrew P. McMahon

  • Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells

    Kathryn Blaschke;Kevin T. Ebata;Mohammad M. Karimi;Mohammad M. Karimi;Jorge A. Zepeda-Martínez

  • Smoothened Mutants Reveal Redundant Roles for Shh and Ihh Signaling Including Regulation of L/R Asymmetry by the Mouse Node

    Xiaoyan M. Zhang;Miguel Ramalho-Santos;Andrew P. McMahon

  • Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells

    Yuki Ohi;Han Qin;Chibo Hong;Laure Blouin

  • Open chromatin in pluripotency and reprogramming

    Alexandre Gaspar-Maia;Adi Alajem;Eran Meshorer;Miguel Ramalho-Santos

  • Chd1 regulates open chromatin and pluripotency of embryonic stem cells

    Alexandre Gaspar-Maia;Adi Alajem;Fanny Polesso;Rupa Sridharan

  • Response to Comments on " 'Stemness': Transcriptional Profiling of Embryonic and Adult Stem Cells" and "A Stem Cell Molecular Signature"

    Natalia B. Ivanova;John T. Dimos;Christoph Schaniel;Jason A. Hackney

  • A LINE1-Nucleolin Partnership Regulates Early Development and ESC Identity.

    Michelle Percharde;Chih-Jen Lin;Yafei Yin;Juan Guan

  • On the origin of the term "stem cell"

    Miguel Ramalho-Santos;Holger Willenbring

  • Generation of induced pluripotent stem cells in the absence of drug selection.

    Robert Blelloch;Monica Venere;Jonathan Yen;Miguel Ramalho-Santos

  • Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy

    Sumaiyah K. Rehman;Jennifer Haynes;Evelyne Collignon;Kevin R. Brown

  • Inhibition of mTOR induces a paused pluripotent state

    Aydan Bulut-Karslioglu;Steffen Biechele;Hu Jin;Trisha A. Macrae

  • YAP Induces Human Naive Pluripotency

    Han Qin;Miroslav Hejna;Yanxia Liu;Michelle Percharde

  • Hira-Mediated H3.3 Incorporation Is Required for DNA Replication and Ribosomal RNA Transcription in the Mouse Zygote

    Chih-Jen Lin;Fong Ming Koh;Priscilla Wong;Marco Conti

  • Bivalent Chromatin Marks Developmental Regulatory Genes in the Mouse Embryonic Germline in Vivo

    Michael Sachs;Courtney Onodera;Kathryn Blaschke;Kevin T. Ebata

  • Somatic cells regulate maternal mRNA translation and developmental competence of mouse oocytes

    Jing Chen;Simona Torcia;Fang Xie;Chih-Jen Lin

  • Homotypic clustering of L1 and B1/Alu repeats compartmentalizes the 3D genome.

    J. Yuyang Lu;Lei Chang;Tong Li;Ting Wang

  • Histone variant H3.3 maintains a decondensed chromatin state essential for mouse preimplantation development

    Chih-Jen Lin;Marco Conti;Miguel Ramalho-Santos

  • Systematic Identification of Barriers to Human iPSC Generation

    Han Qin;Aaron Diaz;Laure Blouin;Robert Jan Lebbink

Frequent Co-Authors

Chih-Jen Lin
Chih-Jen Lin National Taiwan University
Michael T. McManus
Michael T. McManus University of California, San Francisco
Martin Hirst
Martin Hirst University of British Columbia
Douglas A. Melton
Douglas A. Melton Harvard University
Eran Meshorer
Eran Meshorer Hebrew University of Jerusalem
Richard C. Mulligan
Richard C. Mulligan Harvard University
Alma L. Burlingame
Alma L. Burlingame University of California, San Francisco
Anjana Rao
Anjana Rao La Jolla Institute For Allergy & Immunology
Matthias Hebrok
Matthias Hebrok University of California, San Francisco
Hong Wu
Hong Wu Peking University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Studying Molecular Biology opens up a world of scientific opportunities, but it can also serve as a stepping stone to diverse career pathways. Many students supplement their core knowledge with interdisciplinary skills, often earned through online learning platforms.

For those interested in bridging biology and design, exploring fields like bioinformatics or biomedical visualization, you might consider learning skills from the best online graphic design programs. Likewise, the quantitative aspects of molecular research align well with analytical training from online mathematics degrees.

Career opportunities also exist at the intersection of biology and sustainable design. Bigger-picture thinkers may thrive by studying in online architecture programs that emphasize innovation in lab and healthcare facility design.

For those seeking a complete switch, professionals looking to transition, such as educators, can explore a career change for teachers higher pay in fields like speech-language pathology, which draw on scientific and communication skills found in Molecular Biology.

Best Scientists Citing Miguel Ramalho-Santos

Trending Scientists