Michael Leitges

Overview

Best Publications

• Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy.

  Pedro Geraldes;Junko Hiraoka-Yamamoto;Motonobu Matsumoto;Allen Charles Clermont

  500
  Citations

• PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling.

  Thomas T. Su;Beichu Guo;Yuko Kawakami;Karen Sommer

  477
  Citations

• The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis.

  Angeles Durán;Manuel Serrano;Michael Leitges;Juana M Flores

  356
  Citations

• Exacerbated vein graft arteriosclerosis in protein kinase Cδ–null mice

  Michael Leitges;Manuel Mayr;Ursula Braun;Ursula Mayr

  312
  Citations

• Syk kinase-coupled C-type lectin receptors engage protein kinase C-δ to elicit Card9 adaptor-mediated innate immunity

  Dominikus Strasser;Konstantin Neumann;Hanna Bergmann;Mohlopheni J. Marakalala

  303
  Citations

• 12R-lipoxygenase deficiency disrupts epidermal barrier function

  Nikolas Epp;Gerhard Fürstenberger;Karsten Müller;Silvia de Juanes

  239
  Citations

• Characterization of protein kinase C β isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization

  Kiyoshi Suzuma;Noriko Takahara;Izumi Suzuma;Keiji Isshiki

  230
  Citations

• Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo

  Daniel R. Clayburgh;Mark W. Musch;Michael Leitges;Yang Xin Fu

  217
  Citations

• AHI1 is required for photoreceptor outer segment development and is a modifier for retinal degeneration in nephronophthisis

  Carrie M. Louie;Gianluca Caridi;Vanda S. Lopes;Vanda S. Lopes;Francesco Brancati

  206
  Citations

• A Role for the β Isoform of Protein Kinase C in Fear Conditioning

  Edwin J. Weeber;Coleen M. Atkins;Joel C. Selcher;Andrew W. Varga

  206
  Citations

• Muscle-specific knockout of PKC-λ impairs glucose transport and induces metabolic and diabetic syndromes

  Robert V. Farese;Mini P. Sajan;Hong Yang;Pengfei Li

  196
  Citations

• Protein Kinase C-β-Dependent Activation of NF-κB in Stromal Cells Is Indispensable for the Survival of Chronic Lymphocytic Leukemia B Cells In Vivo

  Gloria Lutzny;Thomas Kocher;Marc Schmidt-Supprian;Martina Rudelius

  192
  Citations

• Regulation of B-cell survival by BAFF-dependent PKCdelta-mediated nuclear signalling.

  Ingrid Mecklenbräuker;Susan L. Kalled;Michael Leitges;Fabienne Mackay

  178
  Citations

• Diminished loss of proteoglycans and lack of albuminuria in protein kinase C-alpha-deficient diabetic mice.

  Jan Menne;Joon-Keun Park;Martin Boehne;Marlies Elger

  178
  Citations

• Mechanical stress-activated PKCδ regulates smooth muscle cell migration

  Chaohong Li;Florian Wernig;Michael Leitges;Yanhua Hu

  165
  Citations

• PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans

  Olivier Bezy;Thien T. Tran;Jussi Pihlajamäki;Ryo Suzuki

  162
  Citations

• Ischemic preconditioning exaggerates cardiac damage in PKC-δ null mice

  Manuel Mayr;Bernhard Metzler;Yuen-Li Chung;Emma McGregor

  155
  Citations

• Protein Kinase Cβ Is a Critical Regulator of Dopamine Transporter Trafficking and Regulates the Behavioral Response to Amphetamine in Mice

  Rong Chen;Cheryse A. Furman;Minjia Zhang;Myung N. Kim

  144
  Citations

• IgE- and IgE+Ag-mediated mast cell migration in an autocrine/paracrine fashion

  Jiro Kitaura;Tatsuya Kinoshita;Masaaki Matsumoto;Shaun Chung

  142
  Citations

• Protein Kinase Cα, but Not PKCβ or PKCγ, Regulates Contractility and Heart Failure Susceptibility. Implications for Ruboxistaurin As a Novel Therapeutic Approach

  Qinghang Liu;Xiongwen Chen;Scott M. MacDonnell;Evangelia G. Kranias

  139
  Citations