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Lawrence J. Mandarino

Lawrence J. Mandarino

D-Index & Metrics

Medicine

D-Index
78
Citations
27188
World Ranking
17900
National Ranking
8929

Overview

Lawrence J. Mandarino is affiliated with the University of Arizona in the United States. Their research encompasses multiple disciplines within medicine and biochemistry, genetics, and molecular biology, with significant work in subfields such as physiology, molecular biology, general health professions, cell biology, and endocrinology, diabetes, and metabolism.

Their scholarly output includes papers addressing varied topics related to metabolism, molecular function, and epigenetic regulation. Notable recent publications include:

  • Returning genomic results in a Federally Qualified Health Center: the intersection of precision medicine and social determinants of health, 2020, Genetics in Medicine
  • Can Exercise Training Alter Human Skeletal Muscle DNA Methylation?, 2022, Metabolites
  • Impact of Amerind ancestry and FADS genetic variation on omega-3 deficiency and cardiometabolic traits in Hispanic populations, 2021, Communications Biology
  • Single Mutation in the NFU1 Gene Metabolically Reprograms Pulmonary Artery Smooth Muscle Cells, 2020, Arteriosclerosis Thrombosis and Vascular Biology
  • Weight loss after Roux-En-Y gastric bypass surgery reveals skeletal muscle DNA methylation changes, 2021, Clinical Epigenetics

Mandarino's core research topics focus on adipose tissue and metabolism, muscle metabolism and nutrition, diet and metabolism studies, mitochondrial function and pathology, lipid metabolism and biosynthesis, fatty acid research and health, as well as epigenetics and DNA methylation.

The scientist publishes frequently in journals including:

  • Nutrients
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Physiology
  • Frontiers in Nutrition
  • Biochimica et Biophysica Acta (BBA) - Bioenergetics

Collaborations are a significant aspect of Mandarino's research activities. Frequent co-authors include Dawn K. Coletta, Eleanna De Filippis, Rocio Zapata Bustos, Paul R. Langlais, and Lindsay N. Kohler.

Best Publications

  • Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

    Mary Elizabeth Patti;Atul J. Butte;Sarah Crunkhorn;Kenneth Cusi

  • Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle.

    Kenneth Cusi;Katsumi Maezono;Katsumi Maezono;Abdullah A Osman;Merri Pendergrass;Merri Pendergrass

  • Fuel selection in human skeletal muscle in insulin resistance: a reexamination.

    David E. Kelley;Lawrence J. Mandarino

  • Dose-response characteristics for effects of insulin on production and utilization of glucose in man

    Robert A. Rizza;Lawrence J. Mandarino;John E. Gerich

  • Effect of pioglitazone on abdominal fat distribution and insulin sensitivity in type 2 diabetic patients.

    Yoshinori Miyazaki;Archana Mahankali;Masafumi Matsuda;Srikanth Mahankali

  • Cortisol-Induced Insulin Resistance in Man: Impaired Suppression of Glucose Production and Stimulation of Glucose Utilization due to a Postreceptor Defect of Insulin Action

    Robert A. Rizza;Lawrence J. Mandarino;John E. Gerich

  • Role of the Adipocyte, Free Fatty Acids, and Ectopic Fat in Pathogenesis of Type 2 Diabetes Mellitus: Peroxisomal Proliferator-Activated Receptor Agonists Provide a Rational Therapeutic Approach

    Harold Bays;Lawrence Mandarino;Ralph A. DeFronzo

  • Ceramide Content Is Increased in Skeletal Muscle From Obese Insulin-Resistant Humans

    John M. Adams;Thongchai Pratipanawatr;Rachele Berria;Elaine Wang

  • A Sustained Increase in Plasma Free Fatty Acids Impairs Insulin Secretion in Nondiabetic Subjects Genetically Predisposed to Develop Type 2 Diabetes

    Sangeeta Kashyap;Renata Belfort;Amalia Gastaldelli;Thongchai Pratipanawatr

  • Interaction between glucose and free fatty acid metabolism in human skeletal muscle.

    David E. Kelley;Marian Mokan;Marian Mokan;Jean Aime Simoneau;Lawrence J. Mandarino

  • Effects of Growth Hormone on Insulin Action in Man: Mechanisms of Insulin Resistance, Impaired Suppression of Glucose Production, and Impaired Stimulation of Glucose Utilization

    Robert A Rizza;Lawrence J Mandarino;John E Gerich

  • Improved Glycemic Control and Enhanced Insulin Sensitivity in Type 2 Diabetic Subjects Treated With Pioglitazone

    Yoshinori Miyazaki;Archana Mahankali;Masafumi Matsuda;Leonard Glass

  • Dose-Response Effect of Elevated Plasma Free Fatty Acid on Insulin Signaling

    Renata Belfort;Lawrence Mandarino;Sangeeta Kashyap;Kelly L Wirfel

  • Genome-wide association study of habitual physical activity in over 377,000 UK Biobank participants identifies multiple variants including CADM2 and APOE.

    Yann C. Klimentidis;David A. Raichlen;Jennifer Bea;David O. Garcia

  • Production of insulin resistance by hyperinsulinaemia in man.

    R. A. Rizza;L. J. Mandarino;J. Genest;B. A. Baker

  • Effect of rosiglitazone on glucose and non-esterified fatty acid metabolism in Type II diabetic patients

    Y. Miyazaki;L. Glass;Curtis L Triplitt;M. Matsuda

  • Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes

    A. E. Civitarese;C. P. Jenkinson;D. Richardson;M. Bajaj

  • Abdominal fat distribution and peripheral and hepatic insulin resistance in type 2 diabetes mellitus

    Yoshinori Miyazaki;Leonard Glass;Curtis Triplitt;Estela Wajcberg

  • Quantification of the relative impairment in actions of insulin on hepatic glucose production and peripheral glucose uptake in non-insulin-dependent diabetes mellitus.

    Peter J. Campbell;Lawrence J. Mandarino;John E. Gerich

  • Exercise training increases glycogen synthase activity and GLUT4 expression but not insulin signaling in overweight nondiabetic and type 2 diabetic subjects.

    Christine Y. Christ-Roberts;Thongchai Pratipanawatr;Wilailak Pratipanawatr;Rachele Berria

Frequent Co-Authors

Ralph A. DeFronzo
Ralph A. DeFronzo The University of Texas Health Science Center at San Antonio
Kenneth Cusi
Kenneth Cusi University of Florida
Christian Meyer
Christian Meyer Arizona State University
Robert A. Rizza
Robert A. Rizza Mayo Clinic
Morey W. Haymond
Morey W. Haymond Baylor College of Medicine
David E. Kelley
David E. Kelley University of Pittsburgh
Scott B. Going
Scott B. Going University of Arizona
Susan T. Weintraub
Susan T. Weintraub The University of Texas Health Science Center at San Antonio
Gene E. Alexander
Gene E. Alexander University of Arizona
John E. Gerich
John E. Gerich Mayo Clinic

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