His primary scientific interests are in Internal medicine, Endocrinology, Insulin, Insulin resistance and Type 2 diabetes. As part of his studies on Internal medicine, Lawrence J. Mandarino often connects relevant areas like Diabetes mellitus. His studies deal with areas such as Receptor and Pioglitazone as well as Insulin.
Lawrence J. Mandarino has included themes like Adipose tissue, Stimulation, Mitochondrion and Type 2 Diabetes Mellitus in his Insulin resistance study. His research in Type 2 diabetes intersects with topics in Glucose tolerance test and Lipotoxicity. His Skeletal muscle research integrates issues from Lipid metabolism, Biochemistry, Protein degradation, Connective tissue and Myocyte.
Lawrence J. Mandarino mainly focuses on Internal medicine, Endocrinology, Insulin, Insulin resistance and Skeletal muscle. His Internal medicine research incorporates elements of Diabetes mellitus and Type 2 diabetes. His study in Insulin receptor, Carbohydrate metabolism, Glucose uptake, Glucose clamp technique and Glycogen synthase falls under the purview of Endocrinology.
His Insulin study frequently intersects with other fields, such as Physical exercise. Lawrence J. Mandarino interconnects Whole blood, Adipose tissue, Adipocyte, Glycogenesis and Type 2 Diabetes Mellitus in the investigation of issues within Insulin resistance. His Skeletal muscle research includes themes of Gene expression, Protein metabolism, Proteomics, Human obesity and Mitochondrion.
His primary areas of investigation include Internal medicine, Endocrinology, Skeletal muscle, Gene and Insulin resistance. His Internal medicine study frequently links to adjacent areas such as Cardiology. Within one scientific family, Lawrence J. Mandarino focuses on topics pertaining to Epigenetics under Endocrinology, and may sometimes address concerns connected to Methylation and Reduced representation bisulfite sequencing.
The various areas that Lawrence J. Mandarino examines in his Skeletal muscle study include Amino acid, Myocyte, Biophysics and Gene expression. He is investigating Insulin resistance as part of his Diabetes mellitus and Insulin and Insulin resistance study. His work deals with themes such as Alpha, Bioinformatics, Peroxisome proliferator-activated receptor, Myogenesis and Type 2 Diabetes Mellitus, which intersect with Insulin.
Lawrence J. Mandarino focuses on Internal medicine, Endocrinology, Obesity, Skeletal muscle and Molecular biology. His research on Internal medicine often connects related areas such as Type 2 diabetes. His Endocrinology study combines topics from a wide range of disciplines, such as DNA methylation, Reduced representation bisulfite sequencing, Inflammation, Pulmonary hypertension and Epigenetics.
Lawrence J. Mandarino has researched Obesity in several fields, including Genetics, Biobank, Gene, Genome-wide association study and Leucine. His Skeletal muscle research is multidisciplinary, incorporating perspectives in Amino acid, Protein metabolism, Downregulation and upregulation, Protein biosynthesis and Phosphorylation. The study of Diabetes mellitus and Insulin are components of his Insulin resistance research.
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Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
Mary Elizabeth Patti;Atul J. Butte;Sarah Crunkhorn;Kenneth Cusi.
Proceedings of the National Academy of Sciences of the United States of America (2003)
Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle.
Kenneth Cusi;Katsumi Maezono;Katsumi Maezono;Abdullah A Osman;Merri Pendergrass;Merri Pendergrass.
Journal of Clinical Investigation (2000)
Fuel selection in human skeletal muscle in insulin resistance: a reexamination.
David E. Kelley;Lawrence J. Mandarino.
Dose-response characteristics for effects of insulin on production and utilization of glucose in man
Robert A. Rizza;Lawrence J. Mandarino;John E. Gerich.
American Journal of Physiology (1981)
Effect of pioglitazone on abdominal fat distribution and insulin sensitivity in type 2 diabetic patients.
Yoshinori Miyazaki;Archana Mahankali;Masafumi Matsuda;Srikanth Mahankali.
The Journal of Clinical Endocrinology and Metabolism (2002)
Cortisol-Induced Insulin Resistance in Man: Impaired Suppression of Glucose Production and Stimulation of Glucose Utilization due to a Postreceptor Defect of Insulin Action
Robert A. Rizza;Lawrence J. Mandarino;John E. Gerich.
The Journal of Clinical Endocrinology and Metabolism (1982)
Role of the Adipocyte, Free Fatty Acids, and Ectopic Fat in Pathogenesis of Type 2 Diabetes Mellitus: Peroxisomal Proliferator-Activated Receptor Agonists Provide a Rational Therapeutic Approach
Harold Bays;Lawrence Mandarino;Ralph A. DeFronzo.
The Journal of Clinical Endocrinology and Metabolism (2004)
Ceramide Content Is Increased in Skeletal Muscle From Obese Insulin-Resistant Humans
John M. Adams;Thongchai Pratipanawatr;Rachele Berria;Elaine Wang.
A Sustained Increase in Plasma Free Fatty Acids Impairs Insulin Secretion in Nondiabetic Subjects Genetically Predisposed to Develop Type 2 Diabetes
Sangeeta Kashyap;Renata Belfort;Amalia Gastaldelli;Thongchai Pratipanawatr.
Interaction between glucose and free fatty acid metabolism in human skeletal muscle.
David E. Kelley;Marian Mokan;Marian Mokan;Jean Aime Simoneau;Lawrence J. Mandarino.
Journal of Clinical Investigation (1993)
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