World's Best Scientists 2026 revealed!
Lawrence A. Chasin

Lawrence A. Chasin

D-Index & Metrics

Molecular Biology

D-Index
45
Citations
10393
World Ranking
2844
National Ranking
1361

Overview

Lawrence A. Chasin is affiliated with Columbia University in the United States and has contributed to research predominantly in biochemistry, genetics, and molecular biology. Their work spans several subfields, including molecular biology and genetics, with a focus on mechanisms related to viral infectious diseases and gene expression in insects, CRISPR and genetic engineering, virus-based gene therapy research, as well as RNA and protein synthesis mechanisms.

Their recent scholarly output includes the following papers:

  • A doubly auxotrophic CHO-K1 cell line for the production of recombinant monoclonal antibodies, 2020, Biotechnology and Bioengineering
  • A multiauxotrophic CHO cell line for the rapid isolation of producers of diverse or high levels of recombinant proteins, 2022, Biotechnology and Bioengineering
  • Biotechnology and Bioengineering: Volume 119, Number 6, June 2022, 2022, Biotechnology and Bioengineering

Chasin's frequent coauthors are:

  • Zhimei Du
  • Qinghao Zhang
  • Luke Nelson
  • Steven Huhn
  • Bo Jiang

The primary venue for their publications is the journal Biotechnology and Bioengineering, where all their recent papers have appeared.

The main topics addressed in their research include:

  • Viral Infectious Diseases and Gene Expression in Insects
  • CRISPR and Genetic Engineering
  • Virus-based gene therapy research
  • RNA and protein synthesis mechanisms

Lawrence A. Chasin's contributions to molecular biology and genetics focus on developing novel cell lines for biotechnological applications, particularly related to recombinant protein production and gene editing techniques. Their research involves engineering Chinese hamster ovary (CHO) cells to optimize the production of monoclonal antibodies and recombinant proteins, reflecting an interest in both fundamental biology and applied biotechnology.

Best Publications

  • DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells

    Michael Wigler;Angel Pellicer;Saul Silverstein;Richard Axel

  • Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity

    Gail Urlaub;Lawrence A. Chasin

  • Computational definition of sequence motifs governing constitutive exon splicing

    Xiang H.-F. Zhang;Lawrence A. Chasin

  • Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line

    Jack H. Nunberg;Randal J. Kaufman;Robert T. Schimke;Gail Urlaub

  • Nonsense mutations in the dihydrofolate reductase gene affect RNA processing.

    G Urlaub;P J Mitchell;C J Ciudad;L A Chasin

  • Effect of gamma rays at the dihydrofolate reductase locus: deletions and inversions

    Gail Urlaub;Pamela J. Mitchell;Emmanuel Kas;Lawrence A. Chasin

  • Multiple Splicing Defects in an Intronic False Exon

    Hanzhen Sun;Lawrence A. Chasin

  • Quantitative evaluation of all hexamers as exonic splicing elements

    Shengdong Ke;Shulian Shang;Sergey M. Kalachikov;Irina Morozova

  • Searching for splicing motifs.

    Lawrence A Chasin

  • Point mutation analysis in a mammalian gene: rapid preparation of total RNA, PCR amplification of cDNA, and Taq sequencing by a novel method.

    A M Carothers;G Urlaub;J Mucha;D Grunberger

  • Genetics of somatic mammalian cells. X. Complementation analysis of glycine-requiring mutants.

    Fa-Ten Kao;Lawrence Chasin;Theodore T. Puck

  • Induction and Repression of the Histidine-degrading Enzymes of Bacillus subtilis

    Lawrence A. Chasin;Boris Magasanik

  • Sequence Information for the Splicing of Human Pre-mRNA Identified by Support Vector Machine Classification

    Xiang H.-F. Zhang;Katherine A. Heller;Ilana Hefter;Christina S. Leslie

  • Comparison of multiple vertebrate genomes reveals the birth and evolution of human exons

    Xiang H.-F. Zhang;Lawrence A. Chasin

  • Multiple transcription start sites, DNase I-hypersensitive sites, and an opposite-strand exon in the 5' region of the CHO dhfr gene.

    P J Mitchell;A M Carothers;J H Han;J D Harding

  • The effect of ploidy on chemical mutagenesis in cultured Chinese hamster cells.

    Lawrence A. Chasin

  • Dynamic Regulation of Alternative Splicing by Silencers that Modulate 5′ Splice Site Competition

    Yang Yu;Patricia A. Maroney;John A. Denker;Xiang H.-F. Zhang

  • Exon inclusion is dependent on predictable exonic splicing enhancers.

    Xiang H.-F. Zhang;Thaned Kangsamaksin;Mann S. P. Chao;Joydeep K. Banerjee

  • Human Genomic Sequences That Inhibit Splicing

    William G. Fairbrother;Lawrence A. Chasin

  • Mutations affecting adenine phosphoribosyl transferase activity in Chinese hamster cells

    Lawrence A. Chasin

Frequent Co-Authors

Xiang Zhang
Xiang Zhang University of Hong Kong
Christina S. Leslie
Christina S. Leslie Memorial Sloan Kettering Cancer Center
Zhaohui Feng
Zhaohui Feng Rutgers, The State University of New Jersey
Jingyue Ju
Jingyue Ju Columbia University
Saul Silverstein
Saul Silverstein Columbia University
Theodore T. Puck
Theodore T. Puck Roosevelt Institute
Randal J. Kaufman
Randal J. Kaufman Sanford Burnham Prebys Medical Discovery Institute
Jacqueline K. Barton
Jacqueline K. Barton California Institute of Technology
Michael Wigler
Michael Wigler Cold Spring Harbor Laboratory

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Studying Molecular Biology in the USA can open doors to a variety of related fields and career trajectories. While many students pursue advanced degrees in molecular sciences, others may find intersecting interests in areas like psychology, counseling, human services, or speech-language pathology.

For those interested in health and wellness careers beyond the lab, consider exploring online master's in counseling programs. This path can be ideal if you're fascinated by the human mind and want to support mental health.

Another popular pathway is studying the human brain and behavior through the best online clinical psychology programs. These programs can prepare graduates for impactful roles in mental healthcare and research.

If you’re looking for quicker entry points into the workforce, the human services online program options allow you to gain relevant skills efficiently, leading to jobs in community outreach or support services.

Lastly, if you're considering working with communication disorders, the education required to be a speech pathologist is worth understanding. Molecular biology can provide a strong foundation for understanding the biological basis of communication challenges.

Best Scientists Citing Lawrence A. Chasin

Trending Scientists

Recently Published Articles