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Medicine

D-Index
91
Citations
32697
World Ranking
11698
National Ranking
1110

Overview

John R. Griffiths is affiliated with the University of Manchester in the United Kingdom and has contributed to the field of Biochemistry, Genetics, and Molecular Biology with a particular focus on Molecular Biology and Cancer Research. Their research centers on the intersection of cancer, hypoxia, and metabolism, exploring molecular pathways involved in these processes.

Their recent publications demonstrate a concentration on cancer metabolism and molecular mechanisms related to tumor microenvironments. Notable papers include:

  • Magnetic resonance spectroscopy ex vivo: A short historical review, 2022, NMR in Biomedicine
  • HIF-1-Independent Mechanisms Regulating Metabolic Adaptation in Hypoxic Cancer Cells, 2021, Cells
  • How and Why Are Cancers Acidic? Carbonic Anhydrase IX and the Homeostatic Control of Tumour Extracellular pH, 2020, Cancers
  • Metabolic regulation of the tumour and its microenvironment: The role of Epstein-Barr virus, 2024, International Journal of Cancer
  • Survival Pathways of HIF-Deficient Tumour Cells: TCA Inhibition, Peroxisomal Fatty Acid Oxidation Activation and an AMPK-PGC-1α Hypoxia Sensor, 2022, Cells

Coauthor collaborations have been an integral part of Griffiths's research efforts. Frequent collaborators include:

  • Shen-Han Lee
  • Monika Golinska
  • Alan Soo Beng Khoo
  • Norhafiza Mat Lazim
  • Marion Stubbs

Their work has appeared predominantly in journals such as Cells and Cancers, with additional publications in NMR in Biomedicine, International Journal of Cancer, and Ironmaking & Steelmaking Processes Products and Applications.

Areas of study encompass a range of topics related to cancer biology and metabolic processes, including:

  • Cancer, Hypoxia, and Metabolism
  • Metabolism, Diabetes, and Cancer
  • Cancer-related Molecular Pathways
  • Enzyme function and inhibition
  • ATP Synthase and ATPases Research
  • Metabolomics and Mass Spectrometry Studies
  • Advanced MRI Techniques and Applications

The multidisciplinary nature of their research spans molecular biology, oncology, immunology, and mechanical engineering subfields, indicating a broad approach to understanding biochemical and biophysical processes within cancer and related diseases.

Best Publications

  • Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

    Kenneth P. Olive;Michael A. Jacobetz;Christian J. Davidson;Aarthi Gopinathan;Aarthi Gopinathan

  • SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth

    Thomas Porstmann;Claudio R. Santos;Beatrice Griffiths;Megan Cully

  • Imaging biomarker roadmap for cancer studies.

    James P.B. O'Connor;Eric O. Aboagye;Judith E. Adams;Hugo J.W.L. Aerts;Hugo J.W.L. Aerts

  • Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations.

    P. J. Pollard;J. J. Briere;N. A. Alam;J. Barwell

  • Causes and consequences of tumour acidity and implications for treatment

    Marion Stubbs;Paul M.J McSheehy;John R Griffiths;C.Lindsay Bashford

  • Metabolic profiles of human brain tumors using quantitative in vivo 1H magnetic resonance spectroscopy.

    F A Howe;S J Barton;S A Cudlip;M Stubbs

  • The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis

    Charles E Massie;Andy Lynch;Antonio Ramos-Montoya;Joan Boren

  • The assessment of antiangiogenic and antivascular therapies in early-stage clinical trials using magnetic resonance imaging: issues and recommendations

    Martin O Leach;K Brindle;J Evelhoch;John R Griffiths

  • Dynamic asymmetry of phosphocreatine concentration and O2 uptake between the on‐ and off‐transients of moderate‐ and high‐intensity exercise in humans

    H. B. Rossiter;S. A. Ward;J. M. Kowalchuk;J. M. Kowalchuk;F. A. Howe

  • S -2-hydroxyglutarate regulates CD8 + T-lymphocyte fate

    Petros A. Tyrakis;Asis Palazon;David Macias;Kian. L. Lee

  • Inferences from pulmonary O2 uptake with respect to intramuscular [phosphocreatine] kinetics during moderate exercise in humans.

    H. B. Rossiter;S. A. Ward;V. L. Doyle;F. A. Howe

  • Application of magnetic resonance neurography in the evaluation of patients with peripheral nerve pathology

    Aaron G. Filler;Michel Kliot;Franklyn A. Howe;Cecil E. Hayes

  • Development of a decision support system for diagnosis and grading of brain tumours using in vivo magnetic resonance single voxel spectra.

    Anne R. Tate;Anne R. Tate;Joshua Underwood;Dionisio M. Acosta;Dionisio M. Acosta;Margarida Julià-Sapé

  • Measurement of the extracellular pH of solid tumours in mice by magnetic resonance spectroscopy: a comparison of exogenous 19F and 31P probes

    Agatha S. E. Ojugo;Paul M. J. McSheehy;Dominick J. O. McIntyre;Cheryl McCoy

  • The OxyLite: a fibre-optic oxygen sensor.

    J R Griffiths;S P Robinson

  • Magnetic resonance neurography

    A. G. Filler;Michel Kliot;H. R. Winn;J. S. Tsuruda

  • Multiple Reaction Monitoring to Identify Sites of Protein Phosphorylation with High Sensitivity

    Richard D. Unwin;John R. Griffiths;Michael K. Leverentz;Agnes Grallert

  • Magnetic Resonance Neurography

    F. A. Howe;A. G. Filler;A. G. Filler;B. A. Bell;J. R. Griffiths

  • Combined metabolomic and proteomic analysis of human atrial fibrillation.

    Manuel Mayr;Shamil Yusuf;Graeme Weir;Yuen-Li Chung

  • Automated classification of short echo time in in vivo 1H brain tumor spectra: A multicenter study

    A. Rosemary Tate;A. Rosemary Tate;Carles Majós;Angel Moreno;Franklyn A. Howe

Frequent Co-Authors

Martin O. Leach
Martin O. Leach Royal Marsden NHS Foundation Trust
Ian Judson
Ian Judson Institute of Cancer Research
Anthony D. Whetton
Anthony D. Whetton University of Manchester
Manuel Mayr
Manuel Mayr King's College London
Paul Workman
Paul Workman Institute of Cancer Research
Qingbo Xu
Qingbo Xu King's College London
David E. Neal
David E. Neal University of Cambridge
adrian l harris
adrian l harris University of Oxford
Kevin M. Brindle
Kevin M. Brindle University of Cambridge
Jerry D. Glickson
Jerry D. Glickson University of Pennsylvania

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