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Chemistry

D-Index
48
Citations
7126
World Ranking
15377
National Ranking
419

Overview

David M. Perrin is affiliated with the University of British Columbia in Canada. Their research spans multiple fields, focusing primarily on Medicine, Biochemistry, Genetics and Molecular Biology, and Chemistry. Within these domains, their work extensively covers subfields such as Molecular Biology, Organic Chemistry, Materials Chemistry, Radiology, Nuclear Medicine and Imaging, and Pulmonary and Respiratory Medicine.

Their research topics include Chemical Synthesis and Analysis, Crystallization and Solubility Studies, X-ray Diffraction in Crystallography, Monoclonal and Polyclonal Antibodies Research, Silymarin and Mushroom Poisoning, Peptidase Inhibition and Analysis, and Toxin Mechanisms and Immunotoxins.

David M. Perrin has contributed to a range of recent publications, including:

  • Recent developments in catalytic amide bond formation, 2020, Peptide Science
  • High-Contrast CXCR4-Targeted 18F-PET Imaging Using a Potent and Selective Antagonist, 2020, Molecular Pharmaceutics
  • Salt Metathesis: Tetrafluoroborate Anion Rapidly Fluoridates Organoboronic Acids to give Organotrifluoroborates, 2023, Angewandte Chemie International Edition
  • Design, Synthesis, and Biochemical Evaluation of Alpha-Amanitin Derivatives Containing Analogs of the trans-Hydroxyproline Residue for Potential Use in Antibody-Drug Conjugates, 2021, Chemistry - A European Journal
  • Pharmacokinetics, radiation dosimetry, acute toxicity and automated synthesis of [18F]AmBF3-TATE, 2020, EJNMMI Research

Frequent co-authors in Perrin's work include Jerome Lozada, François Bénard, Alla Pryyma, Brian O. Patrick, and Antonio A. W. L. Wong. Collaborative efforts with these researchers indicate an emphasis on interdisciplinary approaches within their scientific inquiries.

Perrin's publications are distributed among several scientific venues, with notable recurrent contributions to The Cambridge Structural Database, Angewandte Chemie International Edition, Chemistry - A European Journal, The Journal of Organic Chemistry, and Angewandte Chemie.

Additionally, Perrin has contributed to book publications, including one titled UT Extension Personnel Directory, 1910 - 2020, published in 2021 by Newfound Press, the University of Tennessee Libraries eBooks.

Best Publications

  • A Highly Selective DNAzyme Sensor for Mercuric Ions

    Marcel Hollenstein;Christopher Hipolito;Curtis Lam;David Dietrich

  • On the determination of molecular weight of proteins and protein subunits in the presence of 6 M guanidine hydrochloride.

    Agnes. Ullmann;Michel E. Goldberg;David. Perrin;Jacques. Monod

  • Arylfluoroborates and alkylfluorosilicates as potential PET imaging agents: high-yielding aqueous biomolecular 18F-labeling.

    Richard Ting;Michael J Adam;Thomas J Ruth;David M Perrin

  • Bridging the gap between proteins and nucleic acids: a metal-independent RNAseA mimic with two protein-like functionalities.

    David M. Perrin;Thérèse Garestier;Claude Hélène

  • An Organotrifluoroborate for Broadly Applicable One‐Step 18F‐Labeling

    Zhibo Liu;Maral Pourghiasian;Mark Alex Radtke;Joseph Lau

  • Substituent Effects on Aryltrifluoroborate Solvolysis in Water: Implications for Suzuki−Miyaura Coupling and the Design of Stable 18F-Labeled Aryltrifluoroborates for Use in PET Imaging

    Richard Ting;Curtis W. Harwig;Justin Lo;Ying Li

  • A self-cleaving DNA enzyme modified with amines, guanidines and imidazoles operates independently of divalent metal cations (M2+)

    Marcel Hollenstein;Christopher J. Hipolito;Curtis H. Lam;David M. Perrin

  • Toward [18F]-labeled aryltrifluoroborate radiotracers: in vivo positron emission tomography imaging of stable aryltrifluoroborate clearance in mice.

    Richard Ting;Curtis Harwig;Ulrich auf dem Keller;Siobhan McCormick

  • L'opéron : groupe de gènes à expression coordonnée par un opérateur [C. R. Acad. Sci. Paris 250 (1960) 1727–1729]

    François Jacob;David Perrin;Carmen Sánchez;Jacques Monod

  • Base-Promoted Protodeboronation of 2,6-Disubstituted Arylboronic Acids

    Jerome Lozada;Zhibo Liu;David M. Perrin

  • Expanding the catalytic repertoire of nucleic acid catalysts: simultaneous incorporation of two modified deoxyribonucleoside triphosphates bearing ammonium and imidazolyl functionalities.

    David M. Perrin;Thérèse Garestier;Claude Hélène

  • Helix packing of lactose permease in Escherichia coli studied by site-directed chemical cleavage

    Jianhua Wu;D. M. Perrin;D. S. Sigman;H. R. Kaback

  • Toward an RNaseA mimic: A DNAzyme with imidazoles and cationic amines.

    Leonard Lermer;Yoann Roupioz;Richard Ting;David M. Perrin

  • High affinity DNAzyme-based ligands for transition metal cations - a prototype sensor for Hg2+.

    Jason M. Thomas;Richard Ting;David M. Perrin

  • Preclinical Evaluation of a High-Affinity 18F-Trifluoroborate Octreotate Derivative for Somatostatin Receptor Imaging

    Zhibo Liu;Maral Pourghiasian;François Bénard;Jinhe Pan

  • A DNAzyme with three protein-like functional groups: enhancing catalytic efficiency of M2+-independent RNA cleavage.

    Marcel Hollenstein;Christopher J. Hipolito;Curtis H. Lam;David M. Perrin

  • Recent developments in catalytic amide bond formation

    Mihajlo Todorovic;David M. Perrin

  • Synthesis of the Death-Cap Mushroom Toxin α-Amanitin.

    Kaveh Matinkhoo;Alla Pryyma;Mihajlo Todorovic;Brian O. Patrick

  • Triggering DNAzymes with Light: A Photoactive C8 Thioether-Linked Adenosine

    Richard Ting;Leonard Lermer;David M. Perrin

  • One-step (18)F labeling of biomolecules using organotrifluoroborates.

    Zhibo Liu;Kuo-Shyan Lin;François Bénard;Maral Pourghiasian

  • From Unorthodox to Established: The Current Status of 18F-Trifluoroborate- and 18F-SiFA-Based Radiopharmaceuticals in PET Nuclear Imaging

    Vadim Bernard-Gauthier;Justin J. Bailey;Zhibo Liu;Björn Wängler

  • Novel matrix metalloproteinase inhibitor [18F]marimastat-aryltrifluoroborate as a probe for in vivo positron emission tomography imaging in cancer.

    Ulrich auf dem Keller;Caroline L. Bellac;Ying Li;Yuanmei Lou

  • Stoichiometric Leverage: Rapid 18F‐Aryltrifluoroborate Radiosynthesis at High Specific Activity for Click Conjugation

    Zhibo Liu;Ying Li;Jerome Lozada;Paul Schaffer

Frequent Co-Authors

David S. Sigman
David S. Sigman University of California, Los Angeles
Joseph Lau
Joseph Lau Chinese University of Hong Kong
Brian O. Patrick
Brian O. Patrick University of British Columbia
Christopher M. Overall
Christopher M. Overall University of British Columbia
Maurice Hofnung
Maurice Hofnung Institut Pasteur
Mohammad Ali Zolfigol
Mohammad Ali Zolfigol Bu-Ali Sina University
Claude Hélène
Claude Hélène Grenoble Alpes University
Agnes Ullmann
Agnes Ullmann Institut Pasteur
Xiaoyuan Chen
Xiaoyuan Chen National University of Singapore

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